"Activation of mTOR by insulin results in phosphorylation of downstream targets, e.g. 4E-BP1, S6K1 and ribosomal protein S6, resulting in activation of the mRNA-binding steps in translation initiation. Activation of the phosphatidylinositol 3-kinase-mammalian target of rapamycin signalling pathway by amino acids Although it is clear that amino acids, and in particular leucine, enhance phosphorylation of proteins downstream of mTOR, e.g. 4E-BP1 and S6K1, and indeed require mTOR to be active in order to be effective, whether or not they directly regulate mTOR activity is undecided."
"In addition, two proteins that interact with mTOR to target it to two important substrates, eukaryotic initiation factor 4E binding protein 1 and ribosomal protein S6 kinase, have been identified."
"When part of a complex that also contains the proteins raptor and GbetaL, mTOR phosphorylates substrates like S6K1 and 4E-BP1."
"once Akt1 is activated, it initiates a cascade of phosphorylation events targeting mammalian target of rapamycin, mTOR, which in turn phosphorylates the p70S6 kinase and GSK3B"
"Activation of mTOR results in phosphorylation of a variety of substrates, including the eIF4E-binding protein (4E-BP1), and the ribosomal protein S6 protein kinase (S6K1; for review, see Gingras et al. 2001)."