A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

AKT1 activates MTOR. 7 / 53
1 | 7 31
reach
"An established mechanism for eliciting muscle hypertrophy is through the Akt1 pathway, which activates mTOR and p70s6k and ultimately leads to enhanced protein synthesis."
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"In particular, loss of Akt1 decreased mTOR activation by mutant K-ras, because p-S6, p4E-BP1, total 4E-BP1 and total eIF4E were diminished in Akt1 -/- tumors (XREF_FIG)."
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"The PI3K effector Akt and protein kinase B has been found to directly phosphorylate tuberin and is thereby thought to activate mTOR through inhibition of the tuberin and hamartin complex."
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"Leptin-induction of VEGF levels in endometrial cancer cells was related to the activation of MAPK/ERK1/2 and mTOR but not to PI-3K and AKT1 signaling pathway."
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"The present study demonstrates an association between IGF-1R and the phosphatidylinositol 3-kinase (PI3K)/threonine protein kinase B (Akt)/mammalian target of rapamycin mTOR signaling pathway and autophagy."
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"Consistent with this idea, in the presence of activated RAS, activated AKT1 activated mTOR, as judged by phosphorylation of mTOR substrates, 4EBP1 and p70S6K (XREF_FIG)."
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"IGF-1 treatment activated protein kinase B (AKT), which may inhibit autophagy via the AKT and mammalian target of rapamycin signaling pathway."
Kinase-active AKT1 activates MTOR. 7 / 7
4 3 |
bel
"Akt suppresses TSC1/2, leading to the activation of mTOR."
bel
"The pathway consisting of PI3K, Akt, and mammalian target of rapamycin (mTOR), which is downstream of EGFR, is activated early in lung carcinogenesis.83 (-- indicated as early event by authors)"
bel
"Reduced Akt phosphorylation/activation may be responsible for the decreased mTOR signaling, as indicated by down-regulation of the phosphorylation of mTOR downstream target proteins, including 4EBP1 (Thr37/46), S6K1 (Thr389), and S6 (Ser235/236)."
bel
"once Akt1 is activated, it initiates a cascade of phosphorylation events targeting mammalian target of rapamycin, mTOR, which in turn phosphorylates the p70S6 kinase and GSK3B"
bel
"The pathway consisting of PI3K, Akt, and mammalian target of rapamycin (mTOR), which is downstream of EGFR, is activated early in lung carcinogenesis.83 (-- indicated as early event by authors)"
bel
"Akt suppresses TSC1/2, leading to the activation of mTOR."
bel
"once Akt1 is activated, it initiates a cascade of phosphorylation events targeting mammalian target of rapamycin, mTOR, which in turn phosphorylates the p70S6 kinase and GSK3B"
AKT1-E17K activates MTOR. 1 / 1
| 1
reach
"These results were consistent with the fact that AKT1 E17K clones and control cells do not activate mTOR under these growth conditions (XREF_FIG)."
AKT1 phosphorylated on S473, Y474, and T308 activates MTOR. 1 / 1
1 |
biopax:pid
No evidence text available