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IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

AKT1 inhibits TSC2. 5 / 9
2 | 3
reach
"Insulin and growth factors result in protein kinase B (PKB or Akt) phosphorylation, which inhibits tuberin (tuberous sclerosis 2 or TSC2)."
reach
"Akt1 dependent phosphorylation negatively regulates the functioning of TSC1 and TSC2, 2 other factors involved in insulin signaling."
reach
"Akt1 has been found to inhibit cell migration via phosphorylation of the actin binding factor paladin, as well as via the regulation of the nuclear factors of activated T-cells, ERK and TSC2 [XREF_BIBR]."
signor
"We demonstrate that, upon activation of PI3K, tuberin is phosphorylated on consensus recognition sites for PI3K-dependent S/T kinases. Moreover, Akt/PKB can phosphorylate tuberin in vitro and in vivo. We also show that S939 and T1462 of tuberin are PI3K-regulated phosphorylation sites and that T1462 is constitutively phosphorylated in PTEN(-/-) tumor-derived cell lines."
signor
"We demonstrate that, upon activation of PI3K, tuberin is phosphorylated on consensus recognition sites for PI3K-dependent S/T kinases. Moreover, Akt/PKB can phosphorylate tuberin in vitro and in vivo. We also show that S939 and T1462 of tuberin are PI3K-regulated phosphorylation sites and that T1462 is constitutively phosphorylated in PTEN(-/-) tumor-derived cell lines."
Kinase-active AKT1 inhibits TSC2. 1 / 1
1 |
bel
"Akt then phosphorylates tuberin on three residues (S939, S1130 and T1462 of full length human tuberin), and this inhibits the tuberin-hamartin complex through an as-yet-undefined mechanism (reviewed in [8])."