IndraLab

Statements

AKT1 inhibits TSC2. 10 / 14
2 | 8
signor
"We demonstrate that, upon activation of PI3K, tuberin is phosphorylated on consensus recognition sites for PI3K-dependent S/T kinases. Moreover, Akt/PKB can phosphorylate tuberin in vitro and in vivo. We also show that S939 and T1462 of tuberin are PI3K-regulated phosphorylation sites and that T1462 is constitutively phosphorylated in PTEN(-/-) tumor-derived cell lines."
12150915
reach
"Liu et al. evolved a model in which AKT1 induces the 14–3-3-mediated proteolytic degradation of TSC2."
31752925
reach
"Phosphorylated active AKT1 deactivates TSC2 through phosphorylation at S939 and T1462, which results in binding of TSC2 to 14-3-3 [45, 46]."
30212583
reach
"Akt1 dependent phosphorylation negatively regulates the functioning of TSC1 and TSC2, 2 other factors involved in insulin signaling."
21999454
reach
"AKT1 promotes the degradation of TSC2, resulting in decreased activation of Rho, and also regulates the stability and protein expression of the transcription factor NFAT1 (Astrinidis et al., 2002; Lar[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26267533
reach
"Insulin and growth factors result in protein kinase B (PKB or Akt) phosphorylation, which inhibits tuberin (tuberous sclerosis 2 or TSC2)."
25814935
reach
"AKT1 blocks mTORC1 inhibitor TSC2 (30) 172 and further supports the suggestion that up-regulation of mTORC1 components has antiviral effects.173As AKT1 inhibition results in BECN1 up-regulation and autophagy induction (10, 31), SARS-CoV-2 174 growth inhibition was expected."
| DOI
reach
"Akt1 has been found to inhibit cell migration via phosphorylation of the actin binding factor paladin, as well as via the regulation of the nuclear factors of activated T-cells, ERK and TSC2 [XREF_BIBR]."
25721445
reach
"On the other hand, AKT1 was shown to inhibit migration and metastasis by regulating integrin beta1, MMP9, tuberous sclerosis complex 2 (TSC2), and palladin [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
| PMC
signor
"We demonstrate that, upon activation of PI3K, tuberin is phosphorylated on consensus recognition sites for PI3K-dependent S/T kinases. Moreover, Akt/PKB can phosphorylate tuberin in vitro and in vivo. We also show that S939 and T1462 of tuberin are PI3K-regulated phosphorylation sites and that T1462 is constitutively phosphorylated in PTEN(-/-) tumor-derived cell lines."
12150915
Kinase-active AKT1 inhibits TSC2. 1 / 1
1 |
bel
"Akt then phosphorylates tuberin on three residues (S939, S1130 and T1462 of full length human tuberin), and this inhibits the tuberin-hamartin complex through an as-yet-undefined mechanism (reviewed in [8])."
14607085