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IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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AKT1 phosphorylates RPS6KB1. 4 / 4
| 2 2
reach
"Furthermore, upstream overexpression or knockdown of Akt2 or Akt2 phosphorylation inhibition, rather than Akt1 or Akt3, resulted in striking hyperphosphorylation or dephosphorylation of mTOR, p70S6K and rpS6 (all P < 0.05), without any change in total proteins expressions."
rlimsp
"Constitutively active v-AKT highly phosphorylated p70S6K, which was totally inhibited by rapamycin."
rlimsp
"In conclusion, the FFAR1 promoted airway smooth muscle cell proliferation and p70S6K phosphorylation through MEK/ERK and PI3K/Akt signaling pathways."
reach
"In Figures XREF_FIG, application of the phosphoinositide 3-kinase (PI 3-K) inhibitor LY294002 (10 muM) during treatment with either EPO (10 ng/ml) or Wnt1 (100 ng/ml) prevented EPO or Wnt1 from phosphorylating mTOR and p70S6K, illustrating that the PI 3-K and Akt1 pathways are necessary for EPO or Wnt1 to phosphorylate mTOR and p70S6K."
Modified AKT1 leads to the phosphorylation of RPS6KB1. 1 / 1
| 1
reach
"Artificial overexpression of constitutively active Akt1 (by plasmid transduction or lentiviral infection) caused a progressive increase in size and protein content of cultured canine tracheal myocytes and increased p70 (S6Kinase) phosphorylation but not GSK3beta phosphorylation; however, constitutively active Akt1 did not cause disproportionate overaccumulation of smooth muscle (sm) alpha-actin and SM22."
AKT1 phosphorylated on S473 and T308 phosphorylates RPS6KB1 on serine. 1 / 1
1 |
biopax:pid
No evidence text available
AKT1 leads to the phosphorylation of RPS6KB1-S6K. 1 / 1
| 1
reach
"Importantly, UV induced increases in p70 (S6k) phosphorylation at Thr (389) and Thr (421)/Ser (424) were dramatically inhibited by pretreatment of cells with rapamycin, LY294002, or PD98059, whereas overexpression of dominant negative mutants of PKClambda and iota and Akt1 did not inhibit p70 (S6k) phosphorylation at Thr (389) and Thr (421)/Ser (424)."
Kinase-active AKT1 leads to the phosphorylation of RPS6KB1 on T412. 1 / 1
1 |
bel
"Furthermore, Akt, another phosphatidylinositol 3-kinase effector and regulator of S6K1, also increased Thr(389) phosphorylation in a S6K1 activity-dependent manner."