IndraLab

Statements

FOXO1 increases the amount of FOXO1. 10 / 46
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"Increase of miR-155 significantly decreased forkhead box protein O1 (FoxO1) 3 ' UTR luciferase activity and expression and decrease of miR-155 notably increased FoxO1 expression."
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"Administration of an HSF diet blocked hyperacetylation of forkhead transcription factor 1 (FoxO1), a known target of sirtuin 1 (SIRT1), increased nuclear FoxO1 protein levels, and enhanced association of FoxO1 with the AdipoR2 promoter in the livers of ethanol fed mice."
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"These data suggested that when FSH signaling is absent, FoxO1 activates the transcription of FoxO1 and its downstream apoptotic genes, thereby triggering apoptosis in MGCs."
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"Importantly, FOXO1 KI increased the expression of FOXO1 and decreased the p-FOXO1 and total-FoxO1 ratio in the HG treated cells."
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"Indeed, using in vitro culture system, we found that macrophage Foxo1 and β-catenin colocalized in the nucleus, and increased nuclear expression of Foxo1 and β-catenin in response to LPS stimulation."
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"In this present study, we constructed osteoblast conditional FOXO1 knock-out mice and lentivirus-mediated FoxO1 overexpression to investigate maxillary titanium implant osseointegration."
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"In the presence of PsA, by either enforcing nuclear localization (PTEN null ishikawa cells) or increasing the already existing nuclear levels of FOXO1 (PTEN + ECC1 cells), FOXO1 triggered apoptosis."
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"Foxo1 negatively regulated pathogenic Th17 cell function and miR-183C promoted pathogenic cytokine expression of Th17 cells and repressed Foxo1 expression."
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"The ratio of P-Ser256 FOXO1 to total FOXO1 (a transcription factor involved in the regulation of GNG enzymes, including G6Pase and PEPCK) increased 3.0- and 3.6-fold in the 4x and 16x groups, respectively (XREF_FIG C), and analysis of total FOXO1 levels in nuclear enriched fractions detected reductions of 84 and 85%, respectively, compared with the control group (XREF_FIG C)."
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"It is able to induce apoptosis and inhibit proliferation in T790M positive NSCLC cell lines; upregulate the expression of forkhead box protein O1 (FoxO1); downregulate the long lncRNA colon cancer associated transcript 1 (CCAT1) levels in T790M positive NSCLC cell lines; and repress the tumor growth of T790M positive NSCLC xenografts [XREF_BIBR]."
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Modified FOXO1 increases the amount of FOXO1. 10 / 11
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"Therefore, it is unlikely that the differential Foxo1 expression in antigen experienced T cells is caused by varying Foxo1 expression in precursor T cells."
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"In contrast, overexpression of FoxO1 inhibited the viability of MGCs and induced the expression of endogenous FoxO1."
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"In vitro model of DN, over-expression of FoxO1 induced the protein expression of FoxO1 and SERPINB1."
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"Our results showed that overexpression of WT FoxO1 stimulated endogenous FoxO1 expression and FoxO1 promoter activity, as well as elevation of apoptotic signals in MGCs (XREF_FIG and XREF_FIG)."
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"Accordingly, knockdown of FoxO1 expression using siRNA decreased FoxO1 protein levels and promoted cell growth significantly (XREF_FIG)."
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"Additionally, expression of the FOXO1 transcriptional target gene BIM, which is induced by activity withdrawal, was inhibited by overexpression of the dominant negative FOXO1 Ser249Ala mutant but not wildtype FOXO1, implying a critical role for FOXO1 Ser249 in endogenous Bim induction."
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"In addition, lentiviral mediated FOXO1 overexpression in the kidneys of diabetic mice considerably increased FOXO1 expression and activation, while decreasing proteinuria and renal pathological injury."
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"The expression of FOXO1 was increased by FOXO1 overexpression but reduced by miR-1269a mimic, and co-transfection with FOXO1 and miR-1269a could reverse these effects (P < 0.001, Fig."
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"Expression of FoxO1 (3A/LXXAA) mutant abolishes interaction between Sirt1 and FoxO1 and Sirt1 induced stimulation of FoxO1 mediated transcription."
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"As shown in the western blot, overexpression of WT FoxO1 significantly increased endogenous FoxO1 expression, whereas the DBD mutant had no effect (XREF_FIG)."
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Transcriptionally active FOXO1 increases the amount of FOXO1. 2 / 2
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"adenoviral overexpression of FKHRL1 and FKHR in the LAPC4 prostate cancer cell line resulted in apoptosis and induced the expression of many genes The following comes from Table I."
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"Table 1 FROM SUPPLEMENT captures information from the abstract. Table 1. Gene list of the 50 most induced and 50 most repressed genes upon decidualization "
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FOXO1 bound to SET increases the amount of FOXO1. 1 / 1
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"SET and TAF-Ibeta interacted with FoxO1 and activated transcription of FoxO1 target gene, p21."
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Acetylated FOXO1 increases the amount of FOXO1. 1 / 1
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"Although acetylation of FoxO1 increased concomitant to FoxO1 levels, the relative acetylation of FoxO1 to total FoxO1 was unaltered."
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FOXO1 bound to TAF-Ibeta increases the amount of FOXO1. 1 / 1
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"SET and TAF-Ibeta interacted with FoxO1 and activated transcription of FoxO1 target gene, p21."
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FOXO1 increases the amount of FOXO1 phosphorylated on S249. 1 / 1
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"The phosphorylation of FOXO1 at Ser249 disrupted FOXO1 binding with 14-3-3 proteins and thereby promoted the nuclear accumulation of FOXO1 and stimulated FOXO1 dependent transcription, leading to cell death in neurons."
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