IndraLab

Statements

FLT3 activates NPM1. 3 / 3
| 3
reach
"XREF_BIBR Pediatric AML shares mutations in the NPM1 and FLT3 genes with the adult AML, supporting the role of NPM1 and FLT3 mutations in driving AML regardless of the age of disease onset."
26251629
reach
"Pharmacological disruption of the menin-MLL1 interaction suppresses HOX, MEIS1, and FLT3 expression and induces NPM1 mut AML differentiation."
27535106
reach
"A recent study provided evidence that pharmacologic inhibition of menin and DOT1L inhibited HOX and FLT3 expression and promoted differentiation of NPM1 mutated AML."
29343972
Mutated FLT3 activates NPM1. 1 / 1
| 1
reach
"The other common FLT3 mutation, FLT3-TKD, also synergizes with mutated NPM1 and induces a short-latency AML in mice [21]."
| PMC