A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

FLT3 activates NPM1. 3 / 3
| 3
reach
"XREF_BIBR Pediatric AML shares mutations in the NPM1 and FLT3 genes with the adult AML, supporting the role of NPM1 and FLT3 mutations in driving AML regardless of the age of disease onset."
reach
"Pharmacological disruption of the menin-MLL1 interaction suppresses HOX, MEIS1, and FLT3 expression and induces NPM1 mut AML differentiation."
reach
"A recent study provided evidence that pharmacologic inhibition of menin and DOT1L inhibited HOX and FLT3 expression and promoted differentiation of NPM1 mutated AML."