IndraLab

Statements

Mutated FLT3 decreases the amount of CEBPA. 1 / 1
| 1
reach
"14 Additionally, AML specific Flt3 mutations downregulate C/EBPalpha expression and contribute to leukemogenesis."
23598402
Transcriptionally active FLT3 decreases the amount of CEBPA. 1 / 1
1 |
signor
"Oncogenic mutations of Flt3 also result in the activation of aberrant signaling pathways, including strong activation of STAT5, induction of STAT target genes, and repression of myeloid transcription factors c/EBP-3 and Pu.1."
16146838
FLT3 decreases the amount of CEBPA. 1 / 1
| 1
reach
"Considering that all five cell lines expressed relatively high levels of C/EBPalpha, which were not up-regulated by MLN518 treatments (XREF_FIG and XREF_FIG; not depicted), it appears that the suppression of C/EBPalpha expression by mutated FLT3 is not a general mechanism of the differentiation block in human AML cell lines."
16446383