A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

Transcriptionally active FLT3 decreases the amount of CEBPA. 1 / 1
1 |
signor
"Oncogenic mutations of Flt3 also result in the activation of aberrant signaling pathways, including strong activation of STAT5, induction of STAT target genes, and repression of myeloid transcription factors c/EBP-3 and Pu.1."
FLT3 decreases the amount of CEBPA. 1 / 1
| 1
reach
"Considering that all five cell lines expressed relatively high levels of C/EBPalpha, which were not up-regulated by MLN518 treatments (XREF_FIG and XREF_FIG; not depicted), it appears that the suppression of C/EBPalpha expression by mutated FLT3 is not a general mechanism of the differentiation block in human AML cell lines."
Mutated FLT3 decreases the amount of CEBPA. 1 / 1
| 1
reach
"14 Additionally, AML specific Flt3 mutations downregulate C/EBPalpha expression and contribute to leukemogenesis."