A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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ESR2 decreases the amount of ESR1. 10 / 28
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"In summary, these findings collectively suggest that primarily ERalpha promoter C may mediate ERbeta mediated inhibition of ERalpha expression in endometriotic stromal cells (XREF_FIG)."
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"Indeed, we report that ERbeta could reduce more rapidly and strongly the expression of ERalpha in BG-1 cells in the presence of E2, compared to cells in which only ERalpha is present."
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"We predicted that ERbeta activation would increase prosocial behavior, decrease aggression and reduce ERalpha expression in the MEApd and BSTpm of males; however, as control juveniles were expected to be highly prosocial, these behavioral effects might be obscured by an apparent " ceiling effect "."
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"Indeed, we observed that endogenous ERalpha levels in BG-1 cells were strongly reduced by the presence of ERbeta, whereas ERbeta affected less ERalpha levels in PEO-14 cells."
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"As activation of ER-beta decreases ER-alpha expression 58, it may be possible that downregulation of ER-alpha contributed to these observations."
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"The presence of ERbeta strongly diminished ERalpha levels in the presence of E2 (more than 15 fold decrease in 3 h), suggesting that ERbeta enhances the degradation of ERalpha."
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"% Estrogen receptor (ER) beta counteracts the activity of ERalpha in many systems."
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"ERbeta suppresses ERalpha expression and results in strikingly high ERbeta-to-ERalpha ratios in endometriotic cells."
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"In contrast, ERbeta can repress ERalpha expression, and mice lacking ERbeta have increased ERalpha in their bones."
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"It has been demonstrated that when co-expressed in breast cancer cells, ERbeta antagonizes the expression of ERalpha mediated expression of growth regulatory genes, including c-Myc and cyclin D1."
Modified ESR2 decreases the amount of ESR1. 8 / 8
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"In the normal breast, ERbeta is more abundant than is ERalpha; recent data suggest that high levels of ERbeta can down-regulate the expression of ERalpha XREF_BIBR."
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"High levels of ERbeta suppress ERalpha expression."
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"High levels of ERbeta suppress ERalpha expression."
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"The same group demonstrates increased ERbeta levels concomitant with lower ERalpha levels in endometriosis and experimentally demonstrates that knockdown of ERbeta increases ERalpha while overexpression of ERbeta decreases ERalpha levels."
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"In summary, high levels of ERbeta suppress ERalpha expression and response to estradiol in endometriotic stromal cells via binding to nonclassic DNA motifs in alternatively used ERalpha promoters."
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"This increase may be mediated by an increased presence of TEB in the mammary epithelial tree and increased ER-alpha levels, reduced ER-beta levels or both."
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"High levels of ERbeta suppress ERalpha expression and response to estradiol in endometrial and endometriotic stromal cells via binding to classic and nonclassic DNA motifs in alternatively used ERalpha promoters."
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"Knockdown of ESR2 in endometriotic stromal cells increased the expression of ESR1 twofold, and overexpression of ESR2 in endometrial stromal cells reduced the expression of ESR1 by one-half [XREF_BIBR, XREF_BIBR]."