"In summary, these findings collectively suggest that primarily ERalpha promoter C may mediate ERbeta mediated inhibition of ERalpha expression in endometriotic stromal cells (XREF_FIG)."
"Indeed, we report that ERbeta could reduce more rapidly and strongly the expression of ERalpha in BG-1 cells in the presence of E2, compared to cells in which only ERalpha is present."
"We predicted that ERbeta activation would increase prosocial behavior, decrease aggression and reduce ERalpha expression in the MEApd and BSTpm of males; however, as control juveniles were expected to be highly prosocial, these behavioral effects might be obscured by an apparent " ceiling effect "."
"Indeed, we observed that endogenous ERalpha levels in BG-1 cells were strongly reduced by the presence of ERbeta, whereas ERbeta affected less ERalpha levels in PEO-14 cells."
"As activation of ER-beta decreases ER-alpha expression 58, it may be possible that downregulation of ER-alpha contributed to these observations."
"The presence of ERbeta strongly diminished ERalpha levels in the presence of E2 (more than 15 fold decrease in 3 h), suggesting that ERbeta enhances the degradation of ERalpha."
"% Estrogen receptor (ER) beta counteracts the activity of ERalpha in many systems."
"ERbeta suppresses ERalpha expression and results in strikingly high ERbeta-to-ERalpha ratios in endometriotic cells."
"In contrast, ERbeta can repress ERalpha expression, and mice lacking ERbeta have increased ERalpha in their bones."
"It has been demonstrated that when co-expressed in breast cancer cells, ERbeta antagonizes the expression of ERalpha mediated expression of growth regulatory genes, including c-Myc and cyclin D1."