A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

ESR1 activates EGFR. 10 / 43
| 8 33
reach
"By means of siRNA mediated downregulation of CD44 expression and blocking experiments, we identified CD44v6 as a co-receptor for EGF- and ER induced ErbB1 activation and for NRG1 induced ErbB3 and ErbB4 activation."
reach
"G-protein-coupled estrogen receptor (GPER and GPR30) was reported to bind 17beta-estradiol (E 2), tamoxifen, and ICI 182,780 (fulvestrant) and promotes activation of epidermal growth factor receptor (EGFR)-mediated signaling in breast, endometrial and thyroid cancer cells."
reach
"It will also be important to determine if molecular profiling of the primary tumor can predict which tumors are likely to increase the expression of EGFR and HER2 when treated with ER targeted therapy."
reach
"Tamoxifen or estrogen bound membrane and cytoplasmic ER, through multiple interactions with signaling intermediate molecules such as Shc and modulator of nongenomic action of estrogen receptor (MNAR), can activate the EGFR and Her2 signaling pathway."
reach
"Interestingly, the selective estrogen receptor modulator (SERM) tamoxifen and ER antagonist ICI 182,780 both promote GPR30 dependent transactivation of the EGF receptor and subsequent MAPK activation."
reach
"Interestingly, the selective estrogen receptor modulator (SERM) tamoxifen and the antiestrogen ICI 182,780 both promote GPR30 dependent transactivation of the EGF receptor and subsequent MAPK activation."
reach
"ERalpha can also directly activate the epidermal growth factor receptor (EGFR), causing activation of the MAPK and PI3K pathways XREF_BIBR, XREF_BIBR."
reach
"These results establish the interdependence of ERalpha and EGFR signaling, which may be mediated by cytosolic and ligand independent ERalpha."
reach
"Preclinical studies with breast cancer cell lines and limited clinical data suggest that estrogen receptor (ER)-positive breast cancers initially inhibited by tamoxifen or by hormone deprivation can upregulate EGFR and HER2 signaling in order to bypass ER blockade."
reach
"Interestingly, the selective estrogen receptor modulator (SERM) tamoxifen and ER antagonist ICI 182,780 both promote GPR30 dependent transactivation of the EGF receptor and subsequent MAPK activation."
ESR1 bound to estradiol activates EGFR. 1 / 1
| 1
reach
"When bound to estradiol, the ER collaborates with IGF-1R to cause EGFR upregulation."
Transcriptionally active ESR1 activates EGFR. 1 / 1
1 |
bel
"Epidermal growth factor receptor (EGFR) signaling has long been implicated downstream of ERalpha signaling"