IndraLab

Statements

EP300 activates MDM2. 6 / 7
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"We found that p300 and the deacetylase sirtuin 1 (SIRT1) reciprocally modulated the function of MDM2 through shared target Lys sites."
28196907
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"Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF."
17226766
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"Indeed, the fact that p300 functions to destabilize wild-type p53 in certain conditions is supported by multiple lines of evidence, including demonstration that p300 enhances MDM2 mediated destruction of p53 XREF_BIBR, XREF_BIBR."
23133622
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"Consistently, the deacetylase inhibitor, trichostatin A, did not significantly affect the half-life of the endogenous MDM2 protein, whereas p300 enhanced the half-life of MDM2."
12493762
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"A puzzling study has also shown that p300 promotes p53 turnover by recruiting mdm2 [97]."
11553416
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"Second, overexpression of p300 in cells increased the level of the MDM2 protein but not its mRNA."
12493762
EP300 activates MDM2. 1 / 1
1 |
bel
"In addition, p300-deficient (p300(-)) cells fail to undergo G(1)/S arrest after UV irradiation. These abnormalities are associated with prolongation of p53 stability, reduced p53-acetylation, blunting of MDM2 activation, failure to transactivate p21, and a disproportionate increase in PUMA levels."
15123817
EP300 activates MDM2. 1 / 1
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bel
"Fig.1- shows proteins that interact with CBP/300 Transciptional activators= STAT1, (already). SF1, TAL1, p73, Mdm2, HIF2?, ETS1, RXR, p65, Pit1 (POU1F1), HNF4, Stat2, EBNA2 (virus), HPV E2?, BRCA1, p45/NF-E2, c-JUN, c-myb, Tax?, Sap1, YY1, SREBP, ATF-1, ATF-4, Cubitus interuptusm GII3?, vIRF?, JMY, dMAD?, Py LT?, HPV E6, CIITA, Tat(HIV), SF-1, E2F, Ets-1, junB, C/EBPb, (already) GATA-1, Neuro D, Microphthalmia, E1A, Twist, p53 (already), Myo D, pp90 RSK, SMAD (already), ATF-2, c-Fos, SC40?, Large T? p300 k.o. are defective for RXR signal but not CREB"
11279224