IndraLab

Statements

AGT increases the amount of SERPINE1. 10 / 97
2 | 92 3
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"Adenovirus mediated overexpression of clusterin inhibits Ang II stimulated expression of PAI-1, type I collagen, fibronectin and p-Smad3."
25148511
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"Consistent with earlier studies showing that Ang II can activate the MR, XREF_BIBR, XREF_BIBR spironolactone attenuated Ang II stimulated PAI-1 expression suggesting that Ang II increases PAI-1 expression through an MR dependent mechanism in VSMCs."
19225557
bel
"angiotensin II enhances production of IL6 and MCP1 by activation of NFKB in VSMC, and may also alter the fibrinolytic balance by augmenting plasminogen activator inhibitor - 1 expression (90, 91)"
16293001
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"In HO-1 KO mice, AngII strongly induced PAI expression, and overall, the animals with aneurysm had a lower level of PAI (plasminogen activator inhibitor, xref C)."
33467682
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"These observations indicate that the coupling of AT1 receptors with IP hydrolysis and PKC activation may be important for Ang II stimulation of PAI-1 gene expression."
1537291
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"19 Angiotensin II supplementation increases PAI-1 mRNA levels in vitro 6,7 and in vivo."
11832778
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"In the present study, we demonstrate that the inhibition of PI3K in VSMCs by expression of a dominant negative p85alpha mutant lacking the p110 binding domain (Deltap85), or by treatment of cells with LY294002, inhibited Ang II stimulated PAI-1 (plasminogen activator inhibitor-1) mRNA expression."
16569213
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"Because the expression of TF and PAI-1 mRNA induced by Ang II was attenuated by the increase of intracellular concentrations of cAMP by forskolin and 8-bromo-cAMP and because AM increased the intracellular level of cAMP in rat aortic endothelial cells, it was indicated that the inhibitory effect of AM on the expressions of TF and PAI-1 was mainly mediated by the cAMP dependent signal transduction."
11397723
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"Further, Ang II increased phospho-c-Raf (Ser338), phospho-Erk1/2, and PAI-1 expression significantly more in the EC-PKCbeta2Tg mice compared with WT mice with Ang II (by 1.3 +/- 0.1-, 1.4 +/- 0.1-, and 1.5 +/- 0.2-fold, respectively)."
22826029
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"In addition, thrombotic events are observed, since AngII promotes the expression of plasminogen activator inhibitor-1 (PAI-1) and tissue-factors (TFs) [72,73]."
33265982
AGT bound to AGTR1 increases the amount of SERPINE1. 1 / 1
| 1
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"The accumulated AngII binds to the angiotensin II receptor type 1, potentially exacerbating pulmonary vasoconstriction and inducing TF and PAI-1 expression on platelets and the endothelium [31]."
35567609