IndraLab

Statements

ELK1 activates ELK1. 7 / 11
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"As anticipated, the mRNA level of Profilin-1, c-fos and Mmp2 were significantly declined, further confirming the deterioration of Profilin-1 was due to the weakened Elk1 transcriptional activity caused by compromised Elk1 phosphorylation."
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"Furthermore, the ability of active ERK to phosphorylate Elk-1 and enhance Elk-1 transcriptional potential is impaired in suspended fibroblasts."
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"In ES cells, ELK1 phosphorylation induces mediator binding to phospho-ELK1 through an interaction with the MED23 subunit."
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"Our results suggest that ERK MAPK dependent phosphorylation of Elk-1 promotes desumoylation and enhances the functional activity of Elk-1 in human primary articular chondrocytes, similar to previous findings in other biological contexts."
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"GH stimulates the serine phosphorylation of Elk-1, thereby enabling Elk-1 to mediate transcriptional activation."
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"ERK phosphorylates Elk1 on its C-terminal activation domain, thereby potentiating the ability of Elk1 to activate transcription (Marais et al. 1993)."
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"Phosphorylation of Elk-1 by E2 was also mediated via ER and MAPK pathway, suggesting Elk-1 as a mediator of E2 induced down-regulation of MMP-2 gene expression in fibroblast cells."
19861308
ELK1 bound to SRF activates ELK1. 1 / 1
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"We observed inducible binding of Elk-1 and the SRF after 3 and 24 h of treatment with H. pylori, suggesting that the bacteria alone are sufficient to initiate a cascade of signaling events responsible for villin expression. Thus, H. pylori induction of villin in the stomach correlates with activation and cooperative binding of Elk-1 and the SRF to the proximal promoter of villin."
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