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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

EGFR increases the amount of RAS. 1 / 2

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isi

"The change in morphology was accompanied by up-regulation of PD-L1 expression and activation of EGFR and its downstream pathway, independently to RAS mutation status."

31842958

EGFR increases the amount of RAS bound to GTP. 1 / 1

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reach

"Whereas the expression of either EML4-ALK or the PM localized oncogenic EGFR increased wild-type RAS-GTP levels (XREF_FIG A, XREF_FIG C, S3E, S3G, S3I, and S3K), only EML4-ALK increased RAS-GTP levels of cytosolic RAS mutants (XREF_FIG B, XREF_FIG D, S3F, S3H, S3J, and S3L)."

33848463

Kinase-active EGFR increases the amount of RAS. 1 / 1

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bel

"Modified assertion"

12750255

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...