IndraLab

Statements

EGFR activates AKT. 10 / 825
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"Taken together, these findings suggest that EGF and EGFR signaling activates downstream PI3K and Akt to induce FoxO1 nuclear exclusion, which activates MMP7 to promote larynx carcinoma metastasis."
25008564
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"Collectively, these data suggest that dual inhibition of EGFR and SFK can effectively inhibit PI3K-AKT, MAPK and mTOR signaling in MM cells."
20672017
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"Our data suggest that the EGFR might contribute reactivation of either AKT or ERK pathway and combined inhibition of PI3K and AKT and EGFR and ERK pathway could provide an efficient strategy to inhibit the proliferation of susceptible TNBC cells."
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"In particular, EGFR and HER2 and neu activate signaling pathways (PI3K and Akt and ERK1/2 MAP kinase), leading to different cellular processes involved in tumor development, such as cell division and migration, adhesion, differentiation, and apoptosis [XREF_BIBR]."
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"EGFR can activate the PI3K and AKT pathway, which induces proliferation and inhibits apoptosis."
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"Lipid raft cholesterol regulates apoptotic cell death in prostate cancer cells through EGFR mediated Akt and ERK pathways."
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"Engagement of EGFR by its ligand can activate the downstream ERK and PI3K and AKT signaling, which are crucial for the proliferation, migration and invasion of cancer cells."
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"Subsequently, the blockage of EGFR by h-R3 reduces the activation of Akt and result in tumor death."
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"EGFR signaling has been linked to survivin in many cancer studies XREF_BIBR, and it has been shown that EGFR activates the PI3K and Akt pathway leading to upregulation of HIF-1alpha which subsequently activates survivin gene expression by binding to its promoter region XREF_BIBR."
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"In cluster and module1, cluster and module2 and cluster and module3, we observe the interactions between PI3K-Akt and kinase signaling such as ERBB2, EGFR and ERBB4."
29536825
Mutated EGFR activates AKT. 10 / 24
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"Sordella and colleagues showed that these EGFR mutants selectively activate the Akt survival pathway."
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"15 Mutant EGFR, such as exon 19 deletions and L858R, activate Akt and STAT signaling pathways, which protect cells against apoptosis and promote cell survival."
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"Gefitinib induced substantial clinical responses and reduced tumour burden in ~ 10% of patients with chemotherapy-refractory non small cell lung cancers; however, the majority of these patients had EGFR mutations that constitutively activated the antiapoptotic protein AKT (Baselga, 2002; Fukuoka et al, 2003; Kris et al, 2003; Giaccone et al, 2004)."
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"It was also noted that EGFR mutant lung cancer cell lines selectively activate AKT and STAT3 signaling pathways, promoting cell survival."
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"EGFR mutations activate mitogen activated protein kinase (MAPK) / extracellular signal regulated kinase 1/2 (ERK1/2) and phosphatidylinositol 3 ' -kinase-AKT (PI3K and AKT) pro survival pathways."
26639561
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"Our findings that both EML4-ALK and mutant EGFR upregulate PD-L1 by activating PI3K-AKT and MEK-ERK signaling pathways in NSCLC reveal a direct link between oncogenic drivers and PD-L1 expression."
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"EGFRvIII is a constitutively active EGFR mutant that persistently activates the PI3K-Akt signaling compared with the WT EGFR."
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"These results suggest that these constitutively active EGFR mutants down regulate pERK1/2 but do not activate Akt."
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"Mutant EGFR is reported to selectively activate Akt and signal transducer and activator of transcription protein (STAT) signaling pathways that promote cell survival but less effect on the mitogen act[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It is also known that EGFR mutations activated the antiapoptotic protein Akt (Sordella et al, 2004), and that patients whose tumours have activated Akt are more sensitive to TKIs than patient whose tumours are phospho-AKT negative (Cappuzzo et al, 2004)."
16288303
EGFR activates phosphorylated AKT. 10 / 19
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"Inhibition of EGFR activity using cetuximab partially abrogated the feedback activation of phosphorylated receptor tyrosine protein kinase erB-3 (p-HER3) and p-AKT serine/threonine kinase (AKT), as well as prevented reactivation of p-extracellular regulated kinase (ERK) conferred by AZD6244 treatment."
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"The in vivo assay demonstrated that EGFR and SOS1 promoted growth of nuclear p-AKT +, Bcl-2 + cells results in the resistance of hepatoma cells to ASPP2 and p53 complex induced apoptosis and that blocking nuclear translocation of EGFR dramatically improves and enhances the pro apoptotic function of ASPP2."
25980493
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"Co-culture with MRC-5 cells did not protect HCC827 cells from gefitinib induced pEGFR inhibition but significantly increased p-Akt and p-ERK activation compared with the mono-culture cells."
25634113
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"However, in the absence of mutated HRAS, other upstream signaling molecules can also drive EGFR independent stimulation of p-AKT and p-MAPK and lead to erlotinib resistance as well."
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"The transfection of EGFR alone with EGF increased p-Akt modestly."
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"These results recapitulated our in vitro observations using SNB19 and LN444 cells, further suggesting that PKA induced p-S of Dock180 is critical for EGFRvIII stimulated p-Akt, p-Erk1/2, Rac1 activity and cell migration in glioma cells."
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"The results showed that inhibition of EGFR with erlotinib in breast cancer MDA-MB-231 and HBL100 cell lines significant downregulated p-AKT, p-ERK, CD44, KLF4, Myc, Slug and Snail in these cells (XREF_FIG)."
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"In addition, we searched for ser473 p-Akt (p-Akt), which is activated by EGFR, and Epithelial Membrane Antigen (EMA), which is generally used as differential diagnosis marker of mesothelial cells."
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"In addition, we searched for ser473 p-Akt (p-Akt), which is activated by EGFR, and Epithelial Membrane Antigen (EMA), which is generally used as differential diagnosis marker of mesothelial cells."
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"Our above results showed the gefitinib and PA-MSHA could suppress EGFR mediated p-AKT and p-ERK pathway in three lung cancer cell lines, including A549."
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Kinase-active EGFR activates AKT. 4 / 4
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"down-regulation of GAK by small hairpin RNA has two pronounced effects on EGF receptor signaling: (i) the levels of receptor expression and tyrosine kinase activity go up by >50-fold; and (ii) the spectrum of downstream signaling is significantly changed. One very obvious result is a large increase in the levels of activated extracellular signal-regulated kinase 5 and Akt. "
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"Expression of wild-type (wt) Cbp remarkably suppressed EGF-induced activation of Src, ERK1/2, and Akt-1 enzymes, and NIH3T3 cell transformation, as well as colony formation of a breast cancer cell line (MDA-MB-468) in soft agar."
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"The treatment of NCI-N87 cells with EGF resulted in increases in phosphorylation of Erk1/2, Akt, and P38. Blockade of the Erk, phosphatidylinositol-3 kinase/Akt, or P38 pathways in this cell line"
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"EGFR is required for Akt activation."
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Phosphorylated EGFR activates AKT. 2 / 2
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"who discovered that whilst chemically crosslinked cell surface EGFR dimers become phosphorylated and recruit the appropriate adapter proteins, in the absence of ligand these phosphorylated EGFR dimers[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The phosphorylated EGFR will then lead to the activation of the RAS-RAF-MAPK kinase and the PI3K-Akt transduction cascades."
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EGFR-L858R activates AKT. 2 / 2
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"EGFR L858R and PIK3CA H1047R, which preferentially activated Akt, did not stimulate changes in the expression or H3K27ac levels at Spry124 -/- target genes."
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"Oncogenic EGFR L858R and PIK3CA H1047R potently activated Akt but did not induce changes in the expression or chromatin marking at enhancers of Spry124 -/- target genes, suggesting that EGFR L858R and PIK3CA H1047R regulate distinct subsets of genes and enhancers."
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EGFR bound to ERBB2 activates AKT. 2 / 2
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"On the other hand, TGFalpha induced HER2 and EGFR heterodimers and activated both AKT and Erk1/2 (XREF_SUPPLEMENTARY)."
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"For example the ErbB1 and ErbB2 heterodimer was found to activate AKT, which in turn blocks p53 -- a master regulator of apoptosis 47."
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EGFR bound to Y1086 and SH3BGRL3 activates AKT. 1 / 1
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"SH3BGRL3 interacts with phosphor-EGFR at Y1068, Y1086, and Y1173 through Grb2 by its proline rich motif, and activates the Akt associated signaling pathway."
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EGFR-G796D activates AKT. 1 / 1
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"An additional EGFR G796D mutation was detected in an OSI resistant patient, and OSI could not inhibit the EGFR G796D driven proliferation of cells and the activation of ERK and AKT [20]."
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EGFR bound to glycoprotein activates AKT. 1 / 1
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"During entry, HCMV glycoprotein gB binds to the cellular epidermal growth factor receptor (EGFR) initiating directly the activation of the apoptosis suppressor Akt."
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EGFR bound to POSTN activates AKT. 1 / 1
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"Further studies have demonstrated that periostin creates the tumor-supportive microenvironment by binding to EGFR to trigger the Akt and Erk pathway [XREF_BIBR]."
30060755
EGFR bound to Galphai3 and CCDC88A activates AKT. 1 / 1
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"Later we found that GIV 's C-terminus harbors a GEF motif that binds and activates Galphai3 and upon EGF stimulation assembles an EGFR, GIV, and Galphai3 complex at the PM that prolongs association of EGFR with the PM and enhances migratory Akt signaling and cell migration."
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Kinase-active EGFR bound to ERBB2 activates AKT. 1 / 1
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bel
"Modified assertion"
12684395
EGFR bound to ERBB3 activates AKT. 1 / 1
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"In Tam-R cells, HRGbeta1 promoted erbB3 and erbB2 and erbB3 and EGFR heterodimerization, promoted ERK1/2 and AKT pathway activation and increased cell proliferation and invasion."
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EGFR bound to ITGB4 activates AKT. 1 / 1
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"For example, in a newly published study by Leng et al., it was determined that in the context of liver cancer the interaction between ITGB4 and EGFR activates AKT by using FAK instead of SRC [XREF_BIBR]."
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EGFR bound to its activates AKT. 1 / 1
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"EGFR binds with its ligands and subsequently activates downstream MAPK and ERK and PI3K and Akt pathways, which contribute to invasiveness and other malignant phenotypes."
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EGFR bound to beta4-integrin activates AKT. 1 / 1
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"The beta4-integrin can interact with epidermal growth factor receptor (EGFR) and promote AKT signaling pathway [XREF_BIBR]."
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EGFR bound to AR activates AKT. 1 / 1
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"Whereas nuclear ER induces the expression of transforming growth factor (TGF) alpha and amphiregulin (AR), both TGFalpha and AR are able to bind and stimulate EGFR or EGFR and HER2 and consequently activate MAPK and AKT [XREF_BIBR - XREF_BIBR]."
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Mutated EGFR activates phosphorylated AKT. 1 / 1
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"As expected, the p-ERK1/2 and p-AKT were activated by mutant EGFR and inhibited by gefitinib."
25658629
Kinase-active EGFR bound to EGFR activates AKT. 1 / 1
1 |
bel
"Modified assertion"
12684395
EGFR bound to TGFA activates AKT. 1 / 1
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"Whereas nuclear ER induces the expression of transforming growth factor (TGF) alpha and amphiregulin (AR), both TGFalpha and AR are able to bind and stimulate EGFR or EGFR and HER2 and consequently activate MAPK and AKT [XREF_BIBR - XREF_BIBR]."
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EGFR bound to IGF1R activates AKT. 1 / 1
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"A number of clinical studies have shown that treatment of NSCLC cells with EGFR TKIs can induce increased EGFR and IGF-1R heterodimerization and IGF-1R activation [XREF_BIBR, XREF_BIBR], enhancing the downstream PI3K and Akt and Mek and Erk pathways [XREF_BIBR]."
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