IndraLab

Statements

EGFR activates RAF1. 10 / 17
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"However, earlier studies have demonstrated that H202 preferentially enhanced tyrosine phosphorylation of the EGF receptor, src kinase, mitogen activated protein kinase (MAP kinase) and raf-1 kinase as[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In other cell types, TNF-alpha receptors transactivate the EGF receptor, which activates raf-1 kinase."
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"This supports our computational finding that a C-terminal degron (-GA*) is lost in EGFR genetic fusions, which likely lead to increase stability of the resultant fusion proteins.Among RAF1 fusions, RAF1-AGGF1 is the most frequent fusion, with 3′ partners TRAK1 and PHC3 being observed less frequently."
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"Inhibition of EGFR further suppressed the downstream phosphatidylinositol 3-kinase (PI3K)/RAC-alpha serine/threonine protein kinase (AKT) and RAF proto-oncogene serine/threonine protein kinase and extracellular signal regulated kinase signaling pathways and resulted in a decrease in the phosphorylated-forkhead box protein O1 (at Ser256, Thr24 and Ser319) expression level, and induced cell growth inhibition and apoptosis by regulating the expression of apoptosis-and cell cycle associated genes."
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"While it activated Ras, EGFR failed to fully activate Raf-1 in mitosis due to the lack of phosphorylation at Y341 and the lack of dephosphorylation at pS259."
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"In contrast, H (2) O (2)-induced ERK activation is dependent on EGFR activation, which then leads to downstream Raf-1 and MEK-1 activation."
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"This triggers enhanced EGFR/KRAS signaling, which drives BRAF/CRAF and CRAF/CRAF dimerization, thus reactivating MEK and ultimately resulting in suboptimal ERK inhibition (11, 12)."
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"We found that inhibition of EGFR abrogated RAS activation, P-CRAF induction, and P-ERK re-activation upon vemurafenib treatment in BRAF mutant CRC cells (XREF_FIG), suggesting that vemurafenib can produce sustained inhibition of mutant BRAF activity and suppression of ERK phosphorylation in the absence of EGFR mediated feedback signals."
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"As raf-1 can in turn be activated by EGFRs, this result implicates a positive feedback loop that promotes cell survival involving raf and autocrine growth stimulation."
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"In other cell types, TNF-alpha receptors transactivate the EGF receptor, which activates raf-1 kinase."
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Kinase-active EGFR activates RAF1. 1 / 1
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"Modified assertion"
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