A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

EGFR activates RAF1. 7 / 14
| 2 8
sparser
"In other cell types, TNF-alpha receptors transactivate the EGF receptor, which activates raf-1 kinase."
reach
"In other cell types, TNF-alpha receptors transactivate the EGF receptor, which activates raf-1 kinase."
reach
"The activated EGFRvIII induces an activation of Raf-1 by signaling molecules mentioned in the background section."
reach
"In contrast, H (2) O (2)-induced ERK activation is dependent on EGFR activation, which then leads to downstream Raf-1 and MEK-1 activation."
reach
"Inhibition of EGFR further suppressed the downstream phosphatidylinositol 3-kinase (PI3K)/RAC-alpha serine/threonine protein kinase (AKT) and RAF proto-oncogene serine/threonine protein kinase and extracellular signal regulated kinase signaling pathways and resulted in a decrease in the phosphorylated-forkhead box protein O1 (at Ser256, Thr24 and Ser319) expression level, and induced cell growth inhibition and apoptosis by regulating the expression of apoptosis-and cell cycle associated genes."
reach
"Our pervious study showed an increase in EGFR expression in response to lapatinib treatment [XREF_BIBR], raising the possibility that the upregulated EGFR induced the Raf-1 activation."
sparser
"As raf-1 can in turn be activated by EGFRs, this result implicates a positive feedback loop that promotes cell survival involving raf and autocrine growth stimulation."
Kinase-active EGFR activates RAF1. 1 / 1
1 |
bel
"Modified assertion"