"Tiam1, Vav2, and Dock180 have been implicated in epidermal growth factor receptor (EGFR)-mediated activation of Rac1 and Cdc42."
"Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor mediated Rac activation."
"As expected, inhibition of the kinase activity of the EGFR by the pharmacological inhibitor AG1478 abolished activation of both RhoG and Rac1 after 30 s (XREF_FIG E)."
"Here, we show that EGFR activates Rac1 via inducing the accumulation of its specific guanine nucleotide exchange factor, T-cell lymphoma invasion and metastasis 1 (Tiam1) in non-small-cell lung cancer and colon cancer cells."
"PVR and EGFR then induce Rac GTPase activity at the front of the cluster 26."
"Tenascin-C activation of EGFR also stimulates Rac activity in myofibroblasts which, via inhibition of Rho activation, promotes their invasion in collagen gels."
"Consistent with these data, ectopic expression of a PKA inhibitor (PKI) 21 also reduced EGFRvIII promoted p-S of Dock180, p-Erk1/2, p-Akt, Rac1 activity, cell migration and cell proliferation of SNB19 and LN444 glioma cells (XREF_FIG and data not shown)."
"EGF receptor mediates adhesion dependent activation of the Rac GTPase : a role for phosphatidylinositol 3-kinase and Vav2."
"Inhibition of EGFR activity with AG1478 abrogated nucleus pulpous cell proliferation (p < 0.05 for each) and attenuated Rac1 and ERK1/2 activation in nucleus pulpous cells subjected to periodic mechanical stress (p < 0.05 for each)."
"Using an immunoprecipitation (IP) assay to pull down endogenous Dock180 followed by immunoblotting (IB) using a pan anti-p-S antibody, we found that EGFRvIII promoted p-S of Dock180, Rac1 activity and cell migration in SNB19 and LN444 glioma cells that stably expressed EGFRvIII (SNB19 and EGFRvIII and LN444 and EGFRvIII) but not in control SNB19 and LN444 cells expressing GFP (SNB19 and GFP and LN444 and GFP) (XREF_FIG)."