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IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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EGFR activates RAC1. 7 / 51
| 1 9 32
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"Tiam1, Vav2, and Dock180 have been implicated in epidermal growth factor receptor (EGFR)-mediated activation of Rac1 and Cdc42."
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"Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor mediated Rac activation."
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"As expected, inhibition of the kinase activity of the EGFR by the pharmacological inhibitor AG1478 abolished activation of both RhoG and Rac1 after 30 s (XREF_FIG E)."
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"Here, we show that EGFR activates Rac1 via inducing the accumulation of its specific guanine nucleotide exchange factor, T-cell lymphoma invasion and metastasis 1 (Tiam1) in non-small-cell lung cancer and colon cancer cells."
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"PVR and EGFR then induce Rac GTPase activity at the front of the cluster 26."
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"Tenascin-C activation of EGFR also stimulates Rac activity in myofibroblasts which, via inhibition of Rho activation, promotes their invasion in collagen gels."
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"Consistent with these data, ectopic expression of a PKA inhibitor (PKI) 21 also reduced EGFRvIII promoted p-S of Dock180, p-Erk1/2, p-Akt, Rac1 activity, cell migration and cell proliferation of SNB19 and LN444 glioma cells (XREF_FIG and data not shown)."
Kinase-active EGFR activates RAC1. 6 / 6
4 2 |
bel
"Figure 1 | The ErbB signalling network."
bel
"RNAi depletion of beta2-chimaerin significantly extended the duration of Rac activation by EGF, suggesting that beta2-chimaerin serves as a mechanism that self-limits Rac activity in response to EGFR activation."
bel
"Our results also indicate that signaling events downstream of EGFR involved PI3K-dependent activation of Rac1, which mediated the NADPH-generated reactive oxygen species responsible for MMP-9 secretion and activation."
bel
"RNAi depletion of beta2-chimaerin significantly extended the duration of Rac activation by EGF, suggesting that beta2-chimaerin serves as a mechanism that self-limits Rac activity in response to EGFR activation."
bel
"Figure 1 | The ErbB signalling network."
bel
"endogenous P-Rex1 was involved in cell migration of PC12 cells and primary cultured neurons from the embryonic day 14 cerebral cortices, induced by extracellular stimuli (NGF, BDNF, and epidermal growth factor)."