IndraLab

Statements

EGFR activates RAC1. 10 / 48
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"Tiam1, Vav2, and Dock180 have been implicated in epidermal growth factor receptor (EGFR)-mediated activation of Rac1 and Cdc42."
20156964
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"In addition to its role in phosphorylation of p47 phox, c-Src activation also stimulates the transactivation of the epidermal growth factor receptor (EGFR), which evokes phosphatidylinositol 3-kinase-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12967772
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"Consistent with these data, ectopic expression of a PKA inhibitor (PKI) 21 also reduced EGFRvIII promoted p-S of Dock180, p-Erk1/2, p-Akt, Rac1 activity, cell migration and cell proliferation of SNB19 and LN444 glioma cells (XREF_FIG and data not shown)."
23728337
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"Our results identify a novel signaling cascade by which EGFRvIII activates Rac1 through PKA dependent phosphorylation of Dock180 S1250, thereby promoting glioblastoma tumorigenesis and invasion."
23728337
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"These data suggest that p-S-Dock180 S1250 is important for EGFRvIII driven stimulation of p-Erk1/2, Rac1 activity, cell migration, proliferation and survival in vitro."
23728337
sparser
"Our results identify a novel signaling cascade by which EGFRvIII activates Rac1 through PKA-dependent phosphorylation of Dock180 S1250 , thereby promoting glioblastoma tumorigenesis and invasion."
23728337
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"EGFRvIII stimulates Rac1 signaling through phosphorylation of Dock180 which is mediated by SFKs."
28629170
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"Together, our study identifies a bidirectional (phosphorylation and dephosphorylation) regulatory mechanism controlling Tiam1 stability and provides new insights on how EGFR signaling triggers Rac1 activation and cancer development."
25746002
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"Data shown in xref suggested a significant activation of Rac1 by C2-CER in INS 832/13 cells [Panel A; left] and normal rat islets [Panel A; right]."
20493824
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"For example, EGFR has been shown to activate RAC1 by accumulating the RacGEF TIAM1 at the membrane and promoting its GTP-bound state ."
33879799
Kinase-active EGFR activates RAC1. 6 / 6
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"Figure 1 | The ErbB signalling network."
11252954
bel
"RNAi depletion of beta2-chimaerin significantly extended the duration of Rac activation by EGF, suggesting that beta2-chimaerin serves as a mechanism that self-limits Rac activity in response to EGFR activation."
16628218
bel
"endogenous P-Rex1 was involved in cell migration of PC12 cells and primary cultured neurons from the embryonic day 14 cerebral cortices, induced by extracellular stimuli (NGF, BDNF, and epidermal growth factor)."
15858067
bel
"Figure 1 | The ErbB signalling network."
11252954
bel
"Our results also indicate that signaling events downstream of EGFR involved PI3K-dependent activation of Rac1, which mediated the NADPH-generated reactive oxygen species responsible for MMP-9 secretion and activation."
bel
"RNAi depletion of beta2-chimaerin significantly extended the duration of Rac activation by EGF, suggesting that beta2-chimaerin serves as a mechanism that self-limits Rac activity in response to EGFR activation."
16628218