IndraLab

Statements

EGFR phosphorylates MET. 10 / 41
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"The authors proposed that in tumour cells, TGFalpha mediated EGFR activation induces EGFR and c-Met interaction, detectable as co-immunoprecipitation and resulting in increased c-Met phosphorylation and signalling [XREF_BIBR]."
28536399
sparser
"We explored whether inhibition of the SFKs could block EGFR-induced c-Met phosphorylation through the use of pan-SFK inhibitors, PP2 and dasatinib."
21423210
reach
"EGFR and c-Met kinase activity is required for EGF induced c-Met phosphorylation."
24884778
reach
"We proposed that TGFalpha and the autocrine activation of its receptor, epidermal growth factor receptor (EGFR), leads to phosphorylation and activation of c-Met."
10722725
sparser
"These results show for the first time that EGFR activates MET independent of other ERBB family members, and that both wild-type and activated EGFR induce MET phosphorylation."
23794705
reach
"We have also previously demonstrated a reinforcing loop of c-Met-EGFR cross activation initiated by HGF in lung cancer, that occurs via COX-2 activation and involves direct phosphorylation of c-Met by EGFR ligands [XREF_BIBR, XREF_BIBR]."
21390244
sparser
"Gene transcription is required for delayed c-Met activation; however, phosphorylation of c-Met by EGFR occurs without production of HGF or another secreted factor, supporting a ligand-independent mechanism."
21423210
reach
"Gene transcription is required for delayed c-Met activation; however, phosphorylation of c-Met by EGFR occurs without production of hepatocyte growth factor (HGF) or another secreted factor, supporting a ligand independent mechanism."
21423210
rlimsp
"This demonstrates that a transcriptional component is required for EGFR trans-phosphorylation of c-Met and that the increase in c-Met expression is due to new c-Met transcription."
21423210
sparser
"Delayed phosphorylation of c-Met by EGFR does not require HGF and is an example of c-Met ligand-independent signaling."
21390244
EGFR leads to the phosphorylation of MET on tyrosine. 3 / 3
| 3
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"It has been demonstrated that EGFR activation contributes to c-Met tyrosine phosphorylation in a variety of cell models, with varying kinetic parameters Since NSCLC commonly express both receptors, we examined whether EGFR ligands induce c-Met phosphorylation in human NSCLC cell lines."
21423210
reach
"It demonstrated that EGFR activation contributes to c-Met tyrosine phosphorylation [XREF_BIBR]."
24884778
reach
"Here, EGFR ligands induce prolonged c-Met tyrosine phosphorylation after a pronounced delay that is not attributable to an HGF-ligand autocrine production."
21423210
Kinase-active EGFR leads to the phosphorylation of MET on tyrosine. 2 / 2
2 |
bel
"Treatment of Caco-2 and LoVo cells with PGE2 (10 micromolar, 5 mins) significantly increased c-met-R phosphorylation. when these cells were treated with a specific inhibitor Tryphostin AG 1478 of EGFR, PGE2 almost completely inhibited PGE2-induced c-met-R phosphorylation, indicating that functional EGFR is required for PGE2-induced c-Met-R activation."
12958170
bel
"Inhibitors of Src (PP2, SU6656) or EGFR (AG99), but not p145(met) (K252a), effectively blocked tyrosine phosphorylation of p145(met) and promoted cell death accompanied by activation of caspase-like proteases."
17062641