A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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EGFR activates MAPK1. 3 / 66
| 9 10
reach
"In chicken undifferentiated granulosa cells, stimulation of TGFbeta1 on FSHR transcription is abrogated via activation of ERK2 by the EGF receptor ligands (e.g. TGFalpha, betacellulin) [XREF_BIBR], whereas, temporal activation of ERK2 is required for TGFalpha or betacellulin induced TGFbeta1 expression which implicates ERK2 mediated expression of MAPK phosphatases [XREF_BIBR, XREF_BIBR]."
sparser
"Here we demonstrate that EGFR-activated ERK2 binds directly to PKM2 I429/L431 via the ERK2 docking groove and phosphorylates PKM2 Ser37 but not PKM1."
reach
"In estrogen stimulation of lung cancer cells, EGFR ligands are rapidly released, activating the EGFR and mitogen activated protein kinase 1 growth pathways."
Kinase-active EGFR activates MAPK1. 10 / 20
12 8 |
bel
"The treatment of NCI-N87 cells with EGF resulted in increases in phosphorylation of Erk1/2, Akt, and P38. Blockade of the Erk, phosphatidylinositol-3 kinase/Akt, or P38 pathways in this cell line"
bel
"Studies to date suggest that, in these cancers, several (if not all) of the critical downstream signaling pathways, including the phosphoinositide 3-kinase (PI3K)/Akt, signal transducers and activators of transcription, and extracellular signal-regulated kinase 1 and 2 pathways, are solely controlled by EGFR. Thus, when the tumors are exposed to EGFR inhibitors, these intracellular pathways are turned off and the cancer cells undergo apoptosis (21, 22, 24, 25)."
bel
"The treatment of NCI-N87 cells with EGF resulted in increases in phosphorylation of Erk1/2, Akt, and P38. Blockade of the Erk, phosphatidylinositol-3 kinase/Akt, or P38 pathways in this cell line"
bel
"Studies to date suggest that, in these cancers, several (if not all) of the critical downstream signaling pathways, including the phosphoinositide 3-kinase (PI3K)/Akt, signal transducers and activators of transcription, and extracellular signal-regulated kinase 1 and 2 pathways, are solely controlled by EGFR. Thus, when the tumors are exposed to EGFR inhibitors, these intracellular pathways are turned off and the cancer cells undergo apoptosis (21, 22, 24, 25)."
bel
"An important finding is that intact BRCA1 also prevents EGF and IGF-I signaling through ERK to cell proliferation. EGF and IGF-1 are strongly implicated in the biology of human breast cancer, where they signal through this member of the MAP kinase family to cell growth (27, 52)."
bel
"Mig-6 overexpression results in reduced activation of the mitogenactivated protein kinase ERK2 in response to EGF,"
bel
"As previously reported, expression of Dok-R in EGF-stimulated cells resulted in a dramatic decrease in the induction of Erk-2 activation as well as a delay in the activation kinetics (Fig. 1), while Dok-R {Delta}PRR completely lost this Erk-2 attenuating capacity, which demonstrates that the key residues for mediating this attenuation are found within the PRR."
bel
"PK1 induced a time-dependent increase in expression of IL-8 and COX-2, which was significantly reduced by inhibitors of Gq, cSrc, epidermal growth factor receptor (EGFR), and MAPK kinase. Treatment of third-trimester placenta with 40 nm PK1 induced a rapid phosphorylation of cSrc, EGFR, and ERK1/2. Phosphorylation of ERK1/2 in response to PK1 was dependent on sequential phosphorylation of cSrc and EGFR."
bel
"\"Dependence of peroxisome proliferator-activated receptor ligand-induced mitogen-activated protein kinase signaling on epidermal growth factor receptor transactivation.\" In the current study, we demonstrate that various PPARalpha (nafenopin) and gamma (ciglitazone and troglitazone) agonists rapidly induced extracellular signal-regulated kinase (Erk) and/or p38 phosphorylation in rat liver epithelial cells (GN4). The selective epidermal growth factor receptor (EGFR) kinase inhibitors, PD153035 and ZD1839 (Iressa), abolished PPARalpha and gamma agonist-dependent Erk activation."
bel
"addition of AG1478 also suppressed ATP-mediated phosphorylation of ERK1/2 and I-?B? (Fig. 4A), indicating the involvement of EGFR activation in these signaling events."
EGFR activates MAPK1-E322K. 1 / 1
| 1
reach
"To explore the possibility that the MAPK1 E322K mutation may have paradoxically conferred exquisite dependency on aberrant EGFR signaling in this patient, wild-type MAPK1 (CAL-33) and MAPK1 E322K (HSC-6) HNSCC cells were analyzed for relative EGFR protein and pathway activation (XREF_FIG)."
Kinase-active EGFR bound to ERBB2 activates MAPK1. 1 / 1
1 |
bel
"Modified assertion"
EGFR bound to PKM activates MAPK1. 1 / 1
| 1
reach
"PKM2 is directly bound with EGFR activated extracellular signal regulated kinase 2 (ERK2) at PKM2 specific exon 10 encoded Ile 429/Leu 431 through ERK2 docking groove, and is phosphorylated at Ser 37."