A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

EGFR activates ELK1. 3 / 3
| 1 2
reach
"However, activated EGFR is unable to activate ERK1/2 and their downstream substrates RSK and Elk-1."
sparser
"However, activated EGFR is unable to activate ERK1/2 and their downstream substrates RSK and Elk-1."
reach
"Even in this case, the effects were specific, as they were not observed after knockdown of other AP-1 family members like JunB, Jun D and Fra1, nor of Elk-1, a transcription factor which is activated by EGFR activation though a separate mechanism from AP1 XREF_BIBR (XREF_FIG)."
Kinase-active EGFR activates ELK1. 1 / 1
1 |
bel
"This result indicates that centaurin-{alpha}1 is required for the EGF-dependent activation of Elk-1 in T-REx 293 cells. This result indicates that centaurin-{alpha}1 contributes to the phosphorylation of ERK in the EGF signaling pathway. "