A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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EGFR increases the amount of EGFR. 7 / 127
| 79
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"Interestingly, we found that irreversible inhibitors of the EGFR signaling pathway increased in resistant cell lines the expression of multiple EGFR ligands."
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"In this model, all hypothetical patients have driver mutations that activate the EGFR or copy number variations that increase amounts of EGFR, either of which results in increased proliferation and tumor formation."
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"The increased expression of EGFR in HPNE cells that expressed K-ras (GD12) was mediated by both stabilizing EGFR protein and by increasing EGFR transcription."
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"EGFR activation promotes Sox2 expression, which in turn binds to the EGFR promoter and directly up-regulates EGFR expression."
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"The STAT3 activating kinase, JAK2, is activated in GBM cell lines and combined inhibition of JAK2 and EGFR and EGFRvIII abolishes STAT3 activation and synergistically suppresses the growth of EGFR- and EGFRvIII expressing cell lines of breast cancer [XREF_BIBR] and epidermoid carcinoma [XREF_BIBR, XREF_BIBR], and GBM [XREF_BIBR]."
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"The results showed that EGF treatment trigger EGFR and Erk signaling by increased the levels of p-EGFR and p-Erk1/2."
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"Elevated levels of EGFR are usually induced by amplification of the EGFR gene and correlate with tumorigenicity and an unfavorable prognosis."
Modified EGFR increases the amount of EGFR. 6 / 6
| 6
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"In addition, the reduced levels of EGFR leads to decreased EGFR phosphorylation levels at Y992 and T1068, and decreased phosphorylation of EGFR also elicits reduction of several downstream kinase pathways."
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"Importantly, the ligand OSM regulates EGFR phosphorylation in wild type mouse astrocytes, and knockdown of OSMR in EGFRvIII expressing astrocytes reduces the phosphorylation and total levels of EGFRvIII."
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"Overexpression of EGFR on a background of Cbl-b overexpression restored EGFR expression and facilitated activation of EGFR and ERK and Akt compared with Cbl-b overexpression alone (XREF_FIG A)."
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"However, further overexpression of EGFR on a background of Cbl-b overexpression can relieve Cbl-b-mediated EGFR degradation and restore EGFR expression, mesenchymal phenotype, and cell migration capacity in MDR gastric and breast cancer cells."
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"Expression of EGFR (XREF_FIG), but not FSHR (XREF_FIG), after pre-IVM for 2 h was increased by the combination of dbcAMP and IBMX, but not by dbcAMP or IBMX alone (P < 0.05), suggesting a possible regulation of EGFR expression by cAMP."
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"EGFR surface expression increased 4-fold and 6-fold on BM KSL and SLAM + KSL cells, respectively, at 4 hours following 300 cGy irradiation, demonstrating induction of EGFR expression on HSCs following irradiation (XREF_FIG)."
Kinase-active EGFR increases the amount of EGFR bound to GRB2. 3 / 3
3 |
bel
"In this study, we describe the specific interaction of PAK1 with the Grb2 adapter protein both in vitro and in vivo. We identify the site of this interaction as the second proline-rich SH3 binding domain of PAK1. Stimulation of the epidermal growth factor receptor (EGFR) in HaCaT cells enhances the level of EGFR-associated PAK1 and Grb2, although the PAK1-Grb2 association is itself independent of this stimulation. "
bel
"Epidermal growth factor (EGF) stimulates recruitment of RN-tre to the EGF receptor (EGFR) in a Grb2-dependent manner."
bel
"The dimerization of two EGFR family molecules leads to phosphorylation of C-terminal tyrosine residues either by autophosphorylation or by a SRC-related kinase followed by binding of GRB2, a RAS adaptor protein, at the SH2 domain of the receptor; binding of the proline-rich C-terminus of SOS, a guanine nucleotide exchange factor, to the SH3 domain of the receptor; exchange of a GTP from the receptor complex for a GDP from the RAS protein to form activated RAS; activation of phosphatidylinositol-3-kinase (PI-3 kinase) to initiate signaling by the biochemical pathways that are triggered by diacylglycerol production and protein kinase C activation; and activation of the series of cytoplasmic serine and threonine kinases beginning with RAF to initiate signaling by the biochemical pathways that are triggered by members of the MAPK family (e.g. ERK 1 and 2). EGFR signaling also activates other pathways in the cell including the Janus kinase (JAK)/signal transduction activators of transcription (STAT) pathways [80, 81]."
Mutated EGFR increases the amount of EGFR. 3 / 3
| 3
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"One type of EGFR mutation in primary gliomas results in overexpression of an aberrant EGFR messenger RNA (mRNA) that lacks sequences of exons II through VI of the human EGFR gene."
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"Therefore, the exact mechanism remains unclear whether EGFR mutation is the major contributor to EGFR overexpression."
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"It is also possible that EGFR is able to override DOK2 mediated inhibition via mechanisms such as increased expression of EGFR driven by amplification of the mutant EGFR allele."
Kinase-active EGFR increases the amount of EGFR bound to SHC1. 2 / 2
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bel
"Shc products are phosphorylated on tyrosine by the activated epidermal growth factor receptor (EGFR) and become physically associated with EGFR via their SH2 domain. "
bel
"Finally, ErbB-1 activated by all EGF-related peptides (EGF, HB-EGF, BTC and NDF) couples to SHC, whereas only ErbB-1 activated by its own ligands associates with and phosphorylates Cbl."
EGFR increases the amount of mutated EGFR. 2 / 2
| 2
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"Transient transfection of del (E746-A750) EGFR cDNA induced enhanced expression of activated mutant EGFR in PC9 and ER1 (XREF_FIG)."
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"An amplified EGFR gene may lead to expression of mutant EGFR (EGFRvIII) in high grade astrocytomas [XREF_BIBR], providing a possible target for immunotherapy [XREF_BIBR]."
EGFR bound to Sigma-2 receptor increases the amount of EGFR. 1 / 1
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"Sigma-2 receptor associates with EGFR, increases plasma membrane EGFR levels and promotes invasion."
Kinase-active EGFR increases the amount of EGFR bound to IRS1. 1 / 1
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bel
"Significantly, challenge of Tam-R cells with the EGFR-selective tyrosine kinase inhibitor gefitinib, for 7 days, reduces IRS-1/EGFR association"
EGFR increases the amount of phosphorylated EGFR. 1 / 1
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"The constitutive activation of these downstream EGFR signaling proteins agrees with the observed enhanced level of total and phosphorylated EGFR in the absence of the TRPV1."
EGFR bound to EGF increases the amount of EGFR. 1 / 1
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"EGF binding to EGFR in PC3-AR cells exposed to 5alpha-DHT was increased, suggesting an upregulation of EGFR expression by androgens (XREF_FIG)."
Kinase-active EGFR increases the amount of EGFR bound to SOS. 1 / 1
1 |
bel
"The dimerization of two EGFR family molecules leads to phosphorylation of C-terminal tyrosine residues either by autophosphorylation or by a SRC-related kinase followed by binding of GRB2, a RAS adaptor protein, at the SH2 domain of the receptor; binding of the proline-rich C-terminus of SOS, a guanine nucleotide exchange factor, to the SH3 domain of the receptor; exchange of a GTP from the receptor complex for a GDP from the RAS protein to form activated RAS; activation of phosphatidylinositol-3-kinase (PI-3 kinase) to initiate signaling by the biochemical pathways that are triggered by diacylglycerol production and protein kinase C activation; and activation of the series of cytoplasmic serine and threonine kinases beginning with RAF to initiate signaling by the biochemical pathways that are triggered by members of the MAPK family (e.g. ERK 1 and 2). EGFR signaling also activates other pathways in the cell including the Janus kinase (JAK)/signal transduction activators of transcription (STAT) pathways [80, 81]."
EGFR bound to TGFA increases the amount of EGFR. 1 / 1
| 1
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"Renal cancer produced a transforming growth factor-alpha (TGF-alpha), which bound to epidermal growth factor receptor (EGFR) and upregulated the expression of EGFR and TGF-alpha."
Phosphorylated EGFR increases the amount of EGFR. 1 / 1
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"Cell line and human tumor models show that the CQ mediated impairment of maturation from endosome to lysosome results in decreased intralysosomal degradation of phosphorylated EGFR, which in turn causes over-expression of activated EGFR."
Kinase-active EGFR increases the amount of EGFR bound to TNK2. 1 / 1
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bel
"The interaction of ACK1 with EGFR was dependent on the kinase activity or tyrosine phosphorylation of EGFR. "
Kinase-active EGFR increases the amount of EGFR bound to PAK1. 1 / 1
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bel
"In this study, we describe the specific interaction of PAK1 with the Grb2 adapter protein both in vitro and in vivo. We identify the site of this interaction as the second proline-rich SH3 binding domain of PAK1. Stimulation of the epidermal growth factor receptor (EGFR) in HaCaT cells enhances the level of EGFR-associated PAK1 and Grb2, although the PAK1-Grb2 association is itself independent of this stimulation. "
EGFR bound to EGFR_ligand increases the amount of EGFR bound to ERBB2. 1 / 1
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bel
"The first group includes EGF, amphiregulin (AR), and transforming growth factor-alpha (TGF-alpha), which bind specifically to ErbB1; the second group betacellulin (BTC), heparin-binding EGF (HB-EGF), and epiregulin (EPR), which exhibit dual specificity in that they bind ErbB1 and ErbB4. The third group is composed of the neuregulins (NRG) and forms two subgroups based upon their capacity to bind ErbB3 and ErbB4 (NRG-1 and NRG-2) or only ErbB4 (NRG-3 and NRG-4). ErbB2 has no direct ligand and needs a heterodimerization partner to acquire signaling potential ErbB3...has impaired kinase activity."