The INDRA Database: Results

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading
EGFR leads to the phosphorylation of SRC. 10 / 42
| 5 16 21
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"Unlike EGF activated EGFR, CS stimulated EGFR triggers aberrant Src phosphorylation in lung cancer cells."
29286114
sparser
"Abolition of SRC kinases-mediated EGFR phosphorylation has been shown to inhibit EGF-induced proliferation and/or transformation in many types of cancer cells, such as breast cancer cells and cervical cancer cells [ xref , xref ]."
26849234
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"Mechanistically, de4 EGFR significantly upregulated the extracellular regulated protein kinase, AKT, focal adhesion kinase (FAK) and Src phosphorylation and matrix metalloproteinase-9 expression while downregulated the expression of E-cadherin."
23764753
sparser
"NT also induced a time-dependent increase in EGFR Tyr(845) phosphorylation and phosphorylation of c-Src and signal transducer and activator of transcription 5b (Stat5b) (a downstream effector of Tyr(845)), events that were blocked by specific inhibition of c-Src (which mediates Tyr(845) phosphorylation of EGFR) or of EGFR."
16862179
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"VAV1 was activated by Src dependent phosphorylation, which in turn was activated by EGFR, and led to activation of a Rac-Pak-NF-kappaB signalling pathway and cyclin D1 upregulation."
21102635
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"In addition, C-ANP 4-23 treatment also attenuated the enhanced expression of AT1 receptor, Gqalpha, PLCbeta1, Nox4, and p47 phox proteins, the enhanced activation of EGFR, PDGFR, IGF-1R, enhanced phosphorylation of ERK1/2/AKT and c-Src in VSMC from SHR."
29417757
sparser
"They inhibit the phosphorylation of the peptide substrate RR-Src by the EGF receptor purified from ER 22 cells, with IC50 values in the range 0.02-0.45 microns."
8639248
rlimsp
"While, EGFR can phosphorylate Src at Y416 position, oncogenic Src (v-Src) can lead to phosphorylation of EGFR at Y845 site [58]."
22957061
rlimsp
"Starting with 5-S-glutathionyl-beta-alanyl-L-dopa (1) and 5-S-glutathionyl-beta-alanyl-dopamine (2), a series of analogues with truncated glutathionyl and beta-alanyl-dopa moieties were synthesized, and their inhibitory effects on autophosphorylation and substrate phosphorylation reaction by c-Src and by epidermal growth factor receptor (EGFR) were evaluated."
9987835
sparser
"For the first time, we demonstrated that stimulation of the GAGA A R leads to EGFR signaling activation, including elevated expression of EGFR ligands, trans -phosphorytion of the EGFR, and tyrosyl p[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
24296312
EGFR phosphorylates SRC on Y419. 8 / 8
| 2 1 5
rlimsp
"However, when the EGFR is continuously activated (Figure 3C), it might phosphorylate Src at Y416 position to activate the downstream signaling pathway."
22957061
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"Diabetes augmented and treatment with PP2 inhibited the phosphorylation of Src Tyr 416, EGFR Tyr 1173, and p38 and ERK1/2 (XREF_FIG)."
23942551
sparser
"It is previously known that EGFR can phosphorylate Src at Y416 site, whereas activated Src can phosphorylate EGFR at Y845 site in a defined cellular context xref ."
22957061
reach
"The dependency of O 3 -induced EGFR activation on Src activation in HBEC is supported by the findings of O 3 -induced phosphorylation of Src at Y416, the phosphorylation of EGFR at the transactivation site Y845, and the inhibitory effect of Src kinase inhibitors on EGFR phosphorylation."
25303742
rlimsp
"It is previously known that EGFR can phosphorylate Src at Y416 site, whereas activated Src can phosphorylate EGFR at Y845 site in a defined cellular context [58]."
22957061
reach
"Src was not found to be involved in the EGFR activation as indicated by unchanged phosphorylation of Src Tyr 416 and EGFR Tyr 845."
18460189
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"While, EGFR can phosphorylate Src at Y416 position, oncogenic Src (v-Src) can lead to phosphorylation of EGFR at Y845 site XREF_BIBR."
22957061
reach
"It is previously known that EGFR can phosphorylate Src at Y416 site, whereas activated Src can phosphorylate EGFR at Y845 site in a defined cellular context XREF_BIBR."
22957061
EGFR phosphorylates SRC on tyrosine. 3 / 3
| 3
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"We also review the complex regulation by tyrosine phosphorylation by epidermal growth factor receptor (EGF-R), Janus Kinase 3 (JAK3) and Src and the role of phosphatases."
21740967
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"The activated EGFR signals through phosphorylated tyrosine residues to stimulate multiple pathways, including mitogen activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)/Akt, signal transducers and activators of transcription (STAT), phospholipase C, and Src and focal adhesion kinase (Src and FAK) pathways."
22723871
reach
"We also present the complex regulation by tyrosine phosphorylation by epidermal growth factor receptor (EGF-R), Janus Kinase 3 (JAK3) and Src and the role of phosphatases."
21740967
EGFR phosphorylates SRC on Y216. 1 / 1
| 1
rlimsp
"In addition, ZD1839 suppressed EGF-induced stimulation of EGFR autophosphorylation on Y1086 and Grb2-binding Y1068 sites, c-Src phosphorylation on Y215, and Pak1 activity."
14760089
EGFR phosphorylates SRC on P38. 1 / 1
| 1
reach
"Diabetes augmented and treatment with PP2 inhibited the phosphorylation of Src Tyr 416, EGFR Tyr 1173, and p38 and ERK1/2 (XREF_FIG)."
23942551
EGFR phosphorylates SRC at position 2. 1 / 1
| 1
reach
"Diabetes augmented and treatment with PP2 inhibited the phosphorylation of Src Tyr 416, EGFR Tyr 1173, and p38 and ERK1/2 (XREF_FIG)."
23942551
EGFR phosphorylates SRC on Y418. 1 / 1
| 1
rlimsp
"Consistent with previous studies252627, we observed that EGFR autophosphorylation at Tyr1173, Src phosphorylation at Tyr418, tyrosine phosphorylation of β4 integrin, and FAK autophosphorylation at Tyr397 were more prevalent in MDA-MB-231 cells compared to MCF7 cells (Figs 1a and 2a), implying that a tyrosine phosphorylation cascade through EGF/Src-family kinases (SFKs) is associated with β4 integrin/FAK complex formation."
26549523