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EGF activates ERK. 10 / 2279
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"In addition, PDGF-BB, EGF and bFGF were recently reported to activate ERK1/2 in different types of hMSCs (Tamama et al., 2006; Zaragosi et al., 2006)."
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"To explore the timescale at which adaptation occurs, we retriggered ERK activity by a delayed, 2 nd 3 ' EGF or NGF pulse, which only can induce adaptive ERK activity transients."
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"The distinctive kinetics of ERK activation induced by light and EGF was clearly resolved by the normalized ratio of nuclear and cytoplasmic ERK2-GFP fluorescence intensity."
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"This finding suggests that Grb2 is the only adapter involved in the activation of Erk by EGF."
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"These data indicate that EGF stimulates active ERK in a time- and concentration dependent manner in freshly isolated pGCs and that this experimental approach represents an effective manner with which to evaluate the role of EGF and the ERK signal transduction pathway in freshly harvested pGC."
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"EGF activated IκB and Erk whereas TNF activated only IκB (Figure  xref C)."
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"Thus, inhibition of PKHD1 can cause EGF-induced excessive proliferation through decreasing intracellular Ca(2+) resulting in EGF-induced ERK1/2 activation."
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"Preincubation of cells with U0126, an inhibitor of MEK, the major activator of ERK kinase, completely blocked activation of ERK1/2 by either EGF or NA ( xref )."
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"On the other hand, LL-Z1640-2, a natural compound isolated as an anti-protozoan (Ellestad et al., 1978), has been reported to inhibit anisomycin induced JNK and p38 activation but not epidermal growth[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Indeed, the EGFR was not efficiently ubiquitylated in cells that overexpressed cortactin, resulting in inhibition of the ligand induced downregulation of the receptor and sustained epidermal growth factor induced Erk activity."
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EGF activates phosphorylated ERK. 10 / 58
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"EGF also upregulated p-ERK, increased Ki-67 positive cells, and decreased TUNEL positive cells."
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"We analyzed the EGF induced distribution of p-ERK in young HDFs transfected with siRNA1."
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"To test this, we quantified phospho-ERK induced by EGF stimulation in the presence or absence of rapamycin or iRap."
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"ERK1/2 agonist EGF was found to antagonize F 2 inhibition of calcium-free-H and R-induced p-ERK1/2 upregulation in cardiomyocytes."
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"Unlike U937 cells, SKOV3 cells have low basal levels of pAkt and pERK, and pAkt and pERK can be stimulated by epidermal growth factor (EGF) treatment."
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"EGF treatment rapidly and robustly increased p-ERK in 14-day-old differentiated cells."
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"The EGF induced pERK was blocked (gefitinib and vehicle : 16-93%) by gefitinib, with two cell lines (778 : p = 0.0007 and 449B : p = 0.0028) having statistical significance."
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"For the EGFRn-side binder, the dose-dependent reduction in pERK signalling elicited by 1 nM EGF in HUVECs with increasing EGFRn-side minibinder (EGFRn_mb) concentration is shown."
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"That effort (AID 1454) used AlphaScreen technology to assess levels of phosphorylated ERK in lysates of cells treated with EGF."
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"Technical replicates of the same two lysates showed good reproducibility in the observed EGF stimulated induction of p-ERK1/2, and loading controls were consistent across the membrane (XREF_FIG)."
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EGF activates ERK. 8 / 8
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""Roflumilast also inhibited the EGF induced expression of phosphotyrosine proteins, EGF receptor, and phospho-p38- and p44/42-MAPK measured by Western blot analysis in A549 cells""
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"The treatment of NCI-N87 cells with EGF resulted in increases in phosphorylation of Erk1/2, Akt, and P38. Blockade of the Erk, phosphatidylinositol-3 kinase/Akt, or P38 pathways in this cell line"
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"MVP overexpression downregulates EGF-dependent ERK activation in Src overexpressing cells. "
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"We previously reported a relationship between the ambivalent activity of EGF and the p42-mitogen-activated protein (MAP) kinase activity. Thus, 10(-12) M EGF induced a sustained MAP kinase activation, whereas 10(-9) M EGF led to a sharp, but transitory, activation. The MAP kinases are activated by MAP kinase kinases (MEK1 and MEK2)."
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"EGF also prevented H2O2-induced disruption of the actin cytoskeleton and the dissociation of occludin and ZO-1 from the actin-rich detergent-insoluble fractions. MEK (MAPK/ERK kinase, where ERK stands for extracellular signal related kinase) inhibitors, PD98059 and U0126, completely blocked these protective effects of EGF on TJs. EGF rapidly increased the levels of phosphorylated MEK (p-MEK) in detergent-soluble fractions and phosphorylated ERK (p-ERK) in detergent-insoluble fractions. p-ERK was colocalized and co-immunoprecipitated with occludin. "
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"senescence-like growth arrest was accompanied by impaired activation of mitogen-activated protein kinase (MAPK) pathways, namely, extracellular-regulated protein kinase, c-jun N-terminal kinase and p38 MAPK, in response to epidermal growth factor (EGF) and insulin-like growth factor-I (IGF-I)"
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"The SHP2 PTPase activity is required for activation of the extracellular signal-regulated kinase (ERK) subfamily of mitogen-activated protein (MAP) kinase by EGF. "
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"We showed that [D-Lys6]GnRH-II reduces EGF-induced auto-tyrosine-phosphorylation of EGF-receptors via activation of a PTP and that EGF-induced activation of mitogen-activated protein kinase was blocked in cells treated with [D-Lys6]GnRH-II."
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EGF bound to EGFR activates ERK. 5 / 5
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"In primary hepatocyte cultures, EGF or TGFalpha binding to EGF receptor activates Erk1/2 and PI3K pathways, induces cyclin D1 and thus initiates DNA synthesis."
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"In addition, ERK activities can also be induced by EGF/EGFR interaction."
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"The released EGF binds to the EGFR to activate AKT and ERK 1/2."
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"In the absence of cetuximab (XREF_SUPPLEMENTARY), EGF binds to EGFR and activates the AKT and ERK signalling pathways, which are involved in cell survival and proliferation."
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"In RTCs, binding of EGF to EGFR stimulates activities of ERK, phospholipase C (PLC), and SphK, resulting in increased intracellular levels of S1P, while the EGF and EGFR mediated Ca 2+ mobilization, which may regulate apoptosis, requires activation of PLC and SphK in HEK293 cells [XREF_BIBR]."
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EGF bound to SPRED2 activates ERK. 1 / 1
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"Together, these data suggest that p85 binding to Spred2 results in increased Ras association with Spred2, leading to the attenuation of EGF induced Ras and ERK activation.King et al. (2005) found that[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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EGF bound to Ras association and SPRED2 activates ERK. 1 / 1
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"Together, these data suggest that p85 binding to Spred2 results in increased Ras association with Spred2, leading to the attenuation of EGF induced Ras and ERK activation.King et al. (2005) found that[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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EGF bound to GAPVD1 activates ERK. 1 / 1
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"The EGF-mediated interaction of SPIN90 and Gapex5 was completely blocked when we inhibited ERK with PD98059 (Fig. 5a)."
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EGF bound to FN1 activates ERK. 1 / 1
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"In particular, binding of α5β1 to fibronectin, or binding of the epidermal growth factor (EGF) to its receptor (EGFR), triggers MAPK/ERK signaling that coordinates cell survival, proliferation, motility and metabolism [6,132,133,134]."
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EGF bound to NCKIPSD activates ERK. 1 / 1
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"The EGF-mediated interaction of SPIN90 and Gapex5 was completely blocked when we inhibited ERK with PD98059 (Fig. 5a)."
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