A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

EGF leads to the phosphorylation of RB1. 8 / 8
2 | 5 1
sparser
"EGF alone increased the amount of hyperphosphorylated (inactive) pRB; TGF beta blocked EGF-induced pRB phosphorylation, maintaining pRB in the active form."
bel
"In addition, IFN-gamma decreased activation of cdk2 and expression of cyclin E, upstream signaling molecules responsible for Rb hyperphosphorylation in the late G1 phase."
sparser
"TGF-beta converts EGF-induced hyperplasia to hypertrophy and inhibits EGF-induced pRB phosphorylation."
sparser
"Inhibition of AR prevents EGF-induced phosphorylation of Rb."
reach
"Treatment of HT29 cells with AR inhibitor, sorbinil or zopolrestat prevented EGF- and bFGF induced DNA binding activity of E2F-1 and phosphorylation of retinoblastoma protein."
sparser
"Furthermore, when GSK3β was pharmacologically inhibited, EGF induced pRb hyperphosphorylation, cyclin D1 expression, p27 degradation and E2F4 nuclear translocation, four events associated with G1/S phase transition."
bel
"EGF induced the Rb hyperphosphorylation in time dependent manner."
sparser
"This direct antiproliferative effect of acid is associated with inhibition of EGF-induced phosphorylation of the retinoblastoma protein (pRB), which maintains pRB activity and inhibits cell cycle progression from G1 to S phase."