"EGF alone increased the amount of hyperphosphorylated (inactive) pRB; TGF beta blocked EGF-induced pRB phosphorylation, maintaining pRB in the active form."
"In addition, IFN-gamma decreased activation of cdk2 and expression of cyclin E, upstream signaling molecules responsible for Rb hyperphosphorylation in the late G1 phase."
"TGF-beta converts EGF-induced hyperplasia to hypertrophy and inhibits EGF-induced pRB phosphorylation."
"Inhibition of AR prevents EGF-induced phosphorylation of Rb."
"Treatment of HT29 cells with AR inhibitor, sorbinil or zopolrestat prevented EGF- and bFGF induced DNA binding activity of E2F-1 and phosphorylation of retinoblastoma protein."
"Furthermore, when GSK3β was pharmacologically inhibited, EGF induced pRb hyperphosphorylation, cyclin D1 expression, p27 degradation and E2F4 nuclear translocation, four events associated with G1/S phase transition."
"EGF induced the Rb hyperphosphorylation in time dependent manner."
"This direct antiproliferative effect of acid is associated with inhibition of EGF-induced phosphorylation of the retinoblastoma protein (pRB), which maintains pRB activity and inhibits cell cycle progression from G1 to S phase."