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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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EGF activates RAC1. 9 / 288
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"Similar to BDNF, our results show that miR-204 inhibits EGF induced activation of Rac1."
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"EGF and HRG also activate Rac1 in other breast cancer cell lines as well as in immortalized MCF-10A mammary cells (XREF_SUPPLEMENTARY)."
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"Furthermore, two EGF receptor ligands, EGF and TGFalpha, which did activate Rac but did not stimulate MMP-13 production by themselves, promoted higher levels of MMP-13 production when added with Fnf."
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"In addition, depletion of RhoG significantly inhibits EGF stimulated Rac1 activation in these cells."
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"A second wave of EGF-induced Rac1 activation was required for EGF-induced cell migration, however, the spatiotemporal regulation of the second wave of EGF-induced Rac1 activation remains largely unclear."
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"These two waves of lamellipodia formation were reflected by two waves of EGF induced Rac1 activation, which were observed at 2-5min and 6-12h, respectively."
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"As EGFR couples to the DAG-generating enzyme PLCγ in response to stimulation xref , we reasoned that inhibition of PLC should affect Rac activation by EGF."
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"Moreover, it is known that the EGF signaling pathway activates Rac1 and Cdc42 XREF_BIBR, and the IL-4 signaling pathway induces activation of the Rac1, Cdc42, and Wnt signaling pathways XREF_BIBR."
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"While EGF also activates Rac1, this effect is rapid and short lived."
EGF activates RAC1-Q61L. 1 / 1
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"EGF induced a protrusion and retraction cycle in HMEC and Rac Q61L cells that closely mimicked the published dynamics of murine mammary adenocarcinoma cells (XREF_FIG,)."
EGF bound to EGFR and GRB2 activates RAC1. 1 / 1
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bel
"In the present study the function of Ash/Grb-2 was investigated by microinjecting cells with an anti-Ash antibody. The antibody abolished both S phase entry and the reorganization of actin assembly to ruffle formation upon stimulation with epidermal growth factor (EGF) and platelet-derived growth factor (PDGF). On the other hand, anti-Ash antibody had no effect on S phase entry or actin stress fiber formation induced by either serum or lysophosphatidic acid. Since the induction of DNA synthesis, ruffle induction and stress fiber formation involve a function of Ras, Rac activation and Rho activation respectively, the findings strongly suggest that Ash plays a critical role in the signaling of both pathways downstream from growth factor receptors to Ras and Rac. Consistent with this, Ash co-precipitated with EGF receptor from EGF-stimulated cells."
EGF activates RAC1. 1 / 1
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bel
"Rac1 activation by EGF was completely eliminate in cells transfected with pSUPER-beta-Pix (Fig. 2C). This result demonstrates that beta-Pix is an essential GEF for Rac1. # beta-PIX = ARHGEF7"
EGF activates RAC1-R163A. 1 / 1
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"EGF stimulation of wild type Rac1 or Rac1 (R163A) in HeLa cells led to the activation of Rac1 (XREF_FIG)."