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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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EGF leads to the phosphorylation of MAPK1. 10 / 47
4 | 31 12
sparser
"However, a combined inhibition of both p21ras and calcium influx, but not PKC, resulted in a complete inhibition of EGF-induced ERK2 phosphorylation."
bel
"Phosphorylation of p42 and p38 MAPK was not observed in cells treated with both EGF and TNF alpha."
sparser
"Mitogen-activated protein kinase (MAPK) analysis revealed that in Hep2 cells, but not in CO-K3 cells, EGF induced a time-dependent phosphorylation of p42, p44, p38, and p46."
sparser
"Other recent studies show that blockade of endocytosis of EGF receptors by expression of mutant dynamin causes inhibition of EGF-dependent phosphorylation of ERK1, ERK2, and PI3K ( xref )."
reach
"Interestingly, EGF causes phosphorylation of ERK2 only in K-Ras G12D mutated PDECs (XREF_SUPPLEMENTARY)."
reach
"These results demonstrate that in fibroblasts, EGF induces alternative pathways of ERK2 phosphorylation in a cell-type-specific manner."
sparser
"Third, preincubation of cells with the specific MEK1 inhibitor PD098059 attenuated the phosphorylation of ERK2 and ERK1 by EGF."
sparser
"Also, transient upregulation of ATIP1 in cells stably expressing AT2 receptor has been shown to lessen EGF-induced ERK2 phosphorylation compared to wild type cells transfected with ATIP1 ( Nouet et al[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
reach
"Epidermal growth factor induces phosphorylation of extracellular signal regulated kinase 2 via multiple pathways."
sparser
"ERK2 phosphorylation and activation are generally induced by EGF through EGFR and the cytoplasmic RAS/RAF/MEK pathway, with transient responses observed within a period of less than 1 h [18] ."
EGF leads to the phosphorylation of MAPK1 on Y187. 4 / 4
4 |
bel
"from full text - As shown in Figure 2, levels of phosphop42/ p44 after stimulation for 4 h with EGF and thrombin were similar to those stimulated by EGF alone"
bel
"To address this problem, we use quantitative mass spectrometry to analyze dynamic effects of HER2 overexpression on phosphotyrosine signaling in human mammary epithelial cells stimulated by epidermal growth factor (EGF) or heregulin (HRG). [This is from the 'Suplementary Table with Full Data Set\" (http://www.nature.com/msb/journal/v2/n1/suppinfo/msb4100094_S1.html). The cutoff used was a 2.5 fold or greater increase at any of the 5, 10 or 30 minute time points.]"
bel
"Table 4. Quantification data from MRM-QTRAP analyses. Also see fig 4a. 2-fold cutoff; 32 min timepoint FC/ 0 min timepoint FC"
bel
"We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database"
EGF leads to the phosphorylation of MAPK1 on tyrosine. 2 / 2
| 2
reach
"EGF, in a concentration- and time dependent manner, increases tyrosine phosphorylation and MBP kinase activity (i.e. activation) of ERK2, and to a lesser degree ERK1, suggesting that the activation of MAP kinase may mediate the mitogenic action of EGF in pGCs."
reach
"EGF stimulated tyrosine phosphorylation of ERK2, and MK-678 attenuated this effect."
EGF leads to the phosphorylation of MAPK1 on T185. 1 / 1
1 |
bel
"We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database"