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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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EGF activates MAPK1. 10 / 174
| 4 62 61 47
sparser
"Activation of ERK1 and ERK2 by EGF in these cells occurred rapidly, with significant mobility shifts observed as early as 1 min after treatment (Fig. 4) ."
sparser
"The overexpression or reduction of IQGAP1 expression by siRNA both caused the activation of Erk2 by EGF or IGF-1 in MCF-7 cells to be reduced, probably due to an optimal level of intracellular IQGAP1 being necessary for maximal level of activation of Erk by EGF or IGF-1 [ xref ]."
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"Whereas EGF caused a greater activation of ERK-2 than insulin, the converse was true for PKB."
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"AG1478, a specific EGF receptor kinase inhibitor, abolished the prolonged erk-1 and erk-2 activation produced by EGF in cells pretreated with BAPTA/AM."
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"These results suggest that direct or indirect activation of PKA represents a positive regulatory mechanism for EGF stimulation of ERK2 induction."
sparser
"COOK S, RUBINF1ELD B, ALBERT I, MCCORMICK F: RapVl2 Antagonizes Ras-Dependent Activation of ERKI and ERK2 by LPA and EGF in Rat-I Fibroblasts."
sparser
"In the present study we found that the epidermal growth factor activated ERK2 in cerebellar granule neurons and that this activation prohibited glutamate-induced subcellular translocation of NGFI-B. Likewise, overexpressed active ERK2 resulted in a predominant nuclear localization of green fluorescent protein-tagged NGFI-B. Thus, activation of ERK2 may overcome apoptosis-induced subcellular translocation of NGFI-B. This finding represents a novel and rapid growth factor survival pathway that is independent of gene regulation."
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"Overexpressed p74raf-1 potentiates activation of ERK2 by EGF and TPA."
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"Here we show that in COS cells activation of both endogenous ERK2 and Ras by low, but not high, concentrations of epidermal growth factor (EGF) is suppressed by PI 3-kinase inhibitors; since Ras activation is less susceptible than ERK2 activation, PI 3-kinase-sensitive events may occur both upstream of Ras and between Ras and ERK2."
sparser
"Regarding Fig. 2A , it is important to note the high basal activity of p44 when compared to p42 (lane 1); the other major finding remains that neither p42 nor p44 kinases can be further activated by [MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
EGF activates MAPK1. 10 / 14
14 |
bel
"Treating human Panc-48 adenocarcinoma cells with EGF activated Akt and Erk but not P-38."
bel
"Figure 4 shows the inhibitory effect of gefitinib on EGFinduced autophosphorylation of EGFR, and phophorylation of Akt and ERK1/2 in three of the NSCLC cell lines. EGF stimulated EGFR autophosphorylation and activation of Akt and ERK1/2 in PC9 (A), A549 (B), and QG56 (C) cells, and activation was blocked to different extents by gefitinib."
bel
"EGF and thrombin triggered a rapid activation of the EGF receptor, followed by the phosphorylation and activation of the extracellular signal-regulated protein kinase (ERK)"
bel
"PMA (100 nM) and EGF (25 ng/ml) induced the activation of ERK1/ ERK2 in glioblastoma cell lines "
bel
"epidermal growth factor induces immediate, ERK1/ERK2-dependent activation of endogenous ribosomal transcription inactivation of ERK1/ERK2 causes an equally immediate reversion to the basal transcription level"
bel
" We previously reported that the epidermal growth factor (EGF) regulates the gene expression of keratin 16 by activating the extracellular signal-regulated kinase 1 and 2 (ERK1/2) signaling which in turn enhances the recruitment of p300 to the keratin 16 promoter. "
bel
"Here, we show that exposure to 100 ng/ml EGF for 15 min, 1 U/ml GO for 30 min, or smoke from one cigarette for 45 min activates downstream ERK1/2 and Akt signaling (Fig. 7A) "
bel
"activation of p42/p44 MAP kinase by endogenous epidermal growth factor, lysophosphatidic acid, and beta2-adrenergic receptors"
bel
"We show that Cdc2 inhibits EGF-mediated ERK activation through direct interaction and phosphorylation of several ERK pathway proteins, including the guanine nucleotide exchange factor, Sos-1, and Raf-1 kinase."
bel
"expression of ATIP1 in eukaryotic cells leads to inhibition of insulin, basic fibroblast growth factor, and epidermal growth factor-induced ERK2 activation and DNA synthesis, and attenuates insulin receptor autophosphorylation"