"Treating human Panc-48 adenocarcinoma cells with EGF activated Akt and Erk but not P-38."
"Figure 4 shows the inhibitory effect of gefitinib on EGFinduced autophosphorylation of EGFR, and phophorylation of Akt and ERK1/2 in three of the NSCLC cell lines. EGF stimulated EGFR autophosphorylation and activation of Akt and ERK1/2 in PC9 (A), A549 (B), and QG56 (C) cells, and activation was blocked to different extents by gefitinib."
"EGF and thrombin triggered a rapid activation of the EGF receptor, followed by the phosphorylation and activation of the extracellular signal-regulated protein kinase (ERK)"
"PMA (100 nM) and EGF (25 ng/ml) induced the activation of ERK1/ ERK2 in glioblastoma cell lines "
"epidermal growth factor induces immediate, ERK1/ERK2-dependent activation of endogenous ribosomal transcription inactivation of ERK1/ERK2 causes an equally immediate reversion to the basal transcription level"
" We previously reported that the epidermal growth factor (EGF) regulates the gene expression of keratin 16 by activating the extracellular signal-regulated kinase 1 and 2 (ERK1/2) signaling which in turn enhances the recruitment of p300 to the keratin 16 promoter. "
"Here, we show that exposure to 100 ng/ml EGF for 15 min, 1 U/ml GO for 30 min, or smoke from one cigarette for 45 min activates downstream ERK1/2 and Akt signaling (Fig. 7A) "
"activation of p42/p44 MAP kinase by endogenous epidermal growth factor, lysophosphatidic acid, and beta2-adrenergic receptors"
"We show that Cdc2 inhibits EGF-mediated ERK activation through direct interaction and phosphorylation of several ERK pathway proteins, including the guanine nucleotide exchange factor, Sos-1, and Raf-1 kinase."
"expression of ATIP1 in eukaryotic cells leads to inhibition of insulin, basic fibroblast growth factor, and epidermal growth factor-induced ERK2 activation and DNA synthesis, and attenuates insulin receptor autophosphorylation"