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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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EGF leads to the phosphorylation of AKT1. 7 / 7
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"Treatment with AKT inhibitor VIII suppressed EGF stimulated AKT1 phosphorylation in both cell lines, while having no significant effect on the phosphorylation of MEK1."
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"As kinase activation and inhibition has previously been associated with the regulation of the subcellular localisation of huntingtin [XREF_BIBR - XREF_BIBR], we investigated whether the differential responses in AKT1 and MEK1 phosphorylation following EGF stimulation could be reflected in the subcellular localisation of huntingtin."
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"EGF Treatment Upregulates Akt1 Phosphorylation in MED Rats."
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"It was shown that filipin prevented constitutive and EGF stimulated phosphorylation of Akt1, explaining its ability to induce apoptosis and prevent EGF mediated survival."
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"XREF_BIBR Gefitinib, the most effective EGFR inhibitor, efficiently blocked epidermal growth factor (EGF)-stimulated phosphorylation of EGFR, reduced phosphorylation of both MAPK and protein kinase B (AKT), and induced G1 arrest in the TNBC cells."
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"Interestingly, EGF triggers AKT1 phosphorylation via more rapid kinetics than those induced by androgens; this was recently documented by studies on the sensitivity of EGFR family proteins to disruptions in cholesterol synthesis and homeostasis, supporting the functional significance of EGF signal transduction through lipid rafts."
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"As EGF stimulation elicited AKT1 phosphorylation and altered the subcellular localisation of amino-terminal huntingtin in both StHdh Q111 and primary Hdh Q111 cell lines, we sought to investigate whether the phosphorylation of AKT1 may be a mechanism that regulates huntingtin subcellular localisation."
EGF phosphorylates AKT1 on S473. 4 / 4
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"For instances, EGF promotes Ser 473 phosphorylation only in AKT1 in some, but not all, human esophageal squamous cancer cell lines [48] , and exercise activates only AKT1 in rat skeletal muscle [49][MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
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"EGF rapidly phosphorylates Akt-1 at Ser473 with a peak at 15 min and a decrease by 60 min, although it was still higher than controls at 2 hrs."
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"EGF rapidly phosphorylates Akt-1 at Ser473 with a peak at 15 min and a decrease by 60 min, although it was still higher than controls at 2 hrs."
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"Western blotting with the anti-phospho-Akt1 antibody, which recognizes only phosphorylated Ser-473 residue, was performed in human esophageal cancer cell lines (TE-2, TE-5, TE-8, TE-9, TE-10, and TE-12 cells) (top panel). PDGF-treated NIH3T3 cells served as a positive control. The phospho-Akt antibody demonstrated two bands at 60 kDa. The phosphorylation of Akt was enhanced by EGF stimulation in all the esophageal cancer cell lines examined, although TE-5 cells showed high basal phosphorylation of Akt."