"DHT and EGF up-regulated cyclinD1 (CD1) at both mRNA and protein levels in A549 cells"
"Levels of cyclin D1 protein were elevated following 3 h arsenic and EGF (Fig. 2A, row 1 CCND1). The positive control, EGF also induced a large increase in cyclin D1 levels."
"In line with this finding, reconstituted expression of rCdc25A Y59F mutant inhibited EGF enhanced mRNA (XREF_SUPPLEMENTARY) and protein expression (XREF_FIG) of CCND1 and MYC and c-Myc-upregulated GLUT1, PKM2 and LDHA."
"This reflected the observed EGF induced increase in CCND1 mRNA expression (XREF_FIG), occurring irrespective of TIMP1 expression (XREF_FIG) as a confirmation of its separation from invasion signalling."
"In addition, rH3-T11A expression abrogated EGF enhanced mRNA levels of CCND1 and MYC (XREF_FIG), H3-K9 acetylation, and expression of cyclin D1 and c-Myc in both U87 and EGFR (XREF_FIG) and U251 (XREF_SUPPLEMENTARY) cells."
"We previously reported that EGF and PGE 2 alone induced the transcription of the nuclear EGFR-target genes CCND1, PTGS2, MYC and NOS2, with a maximal activation at 2 h and 4 h, respectively [XREF_BIBR]."
"Both EGR1 and CCND1 mRNA expression were upregulated by about 1.5 fold in U251 cells and U251SLCs by EGF."