"DHT and EGF up-regulated cyclinD1 (CD1) at both mRNA and protein levels in A549 cells"
"Levels of cyclin D1 protein were elevated following 3 h arsenic and EGF (Fig. 2A, row 1 CCND1). The positive control, EGF also induced a large increase in cyclin D1 levels."
"In line with this finding, reconstituted expression of rCdc25A Y59F mutant inhibited EGF enhanced mRNA (XREF_SUPPLEMENTARY) and protein expression (XREF_FIG) of CCND1 and MYC and c-Myc-upregulated GLUT1, PKM2 and LDHA."
"This reflected the observed EGF induced increase in CCND1 mRNA expression (XREF_FIG), occurring irrespective of TIMP1 expression (XREF_FIG) as a confirmation of its separation from invasion signalling."