IndraLab

Statements

EGF phosphorylates RPS6KB1. 10 / 29
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"We determined that EGF activates phosphorylation of Akt, mTOR, p70S6 kinase, ribosomal protein S6, eIF4E and 4E-BP1 in a PI-3-kinase dependent manner, and PI-3-kinase activation may prevent lactogenic differentiation in HC11 mammary epithelial cells by regulating the synthesis of proteins."
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"Indeed, western blotting analysis suggests that ouabain treatment reduced EGF-induced phosphorylation of ERK 1/2 and P70S6K (the downstream target of mTOR pathway), but not AKT or 4EBP1 ( xref )."
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"BI-D1870 and SL0101 showed no important change in EGF-induced phosphorylation of rpS6 and p70S6K ( Fig. 7 F and G)."
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"We showed that EGF treatment induced the internalization of NKP from the cell membrane of pII cells to the cytoplasmic compartment and ouabain treatment inhibited EGF induced phosphorylation of p70S6K and ERK 1/2 in agreement with previous reports [ xref , xref ]."
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"Everolimus efficiently inhibited EGF dependent phosphorylation of p70S6K in all the cell lines, without affecting or even inducing phosphorylation of Akt and MAPK."
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"EGF, FGF2, and PDGF-BB stimulation activated mTOR signaling using p70S6K1 phosphorylation as the readout (XREF_FIG)."
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"Ouabain inhibited EGF-induced phosphorylation of Rac/cdc42, profillin, ERK1/2 and P70S6K."
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"MEL specifically inhibited the EGF induced HIF-1alpha expression by suppressing the phosphorylation of ERK, mTOR and p70S6K and also blocked the EGF induced DNA binding activity of HIF-1alpha and the secretion of VEGF."
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"In SMMC7721 and HepG2 cells, EGF markedly increases the phosphorylation of Akt and p70S6K and reverses LC3II, which suggests that the autophagy is due to the PI3K/AKT/mTOR pathway."
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"BI-D1870 showed no important change in EGF-induced phosphorylation of rpS6 and p70S6K ( Fig. 7 F and G)."
25889895
EGF leads to the phosphorylation of RPS6KB1 on T412. 1 / 1
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"TABLE V Survey of cell signaling proteins that show a reaction to EGF ligand stimulation over a 180-min time course - 500ng/mL EGF results"
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EGF leads to the phosphorylation of RPS6KB1-S6K. 1 / 1
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"Phosphorylation of p70 (S6K) was also increased by IGF-1 and glucose, but not by TGF-alpha and EGF, despite upstream PKB activation."
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