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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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EGF leads to the phosphorylation of RPS6KB1. 10 / 24
| 13 11
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"We determined that EGF activates phosphorylation of Akt, mTOR, p70S6 kinase, ribosomal protein S6, eIF4E and 4E-BP1 in a PI-3-kinase dependent manner, and PI-3-kinase activation may prevent lactogenic differentiation in HC11 mammary epithelial cells by regulating the synthesis of proteins."
sparser
"Indeed, western blotting analysis suggests that ouabain treatment reduced EGF-induced phosphorylation of ERK 1/2 and P70S6K (the downstream target of mTOR pathway), but not AKT or 4EBP1 ( xref )."
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"In contrast, in MCF10A cells, and those expressing SCRIBWT, EGF stimulation did not significantly increase p70S6K phosphorylation up to 45 minutes after stimulation."
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"EGF stimulation induced phosphorylation of p70 in HepG2 and Hep3B, and to a lesser extent in Huh7 cells."
sparser
"Also harmine treatment was able to interfere with EGF-stimulated S6K1 phosphorylation, although to a lesser degree ( Figure S3 B)."
sparser
"BI-D1870 and SL0101 showed no important change in EGF-induced phosphorylation of rpS6 and p70S6K ( Fig. 7 F and G)."
sparser
"BI-D1870 showed no important change in EGF-induced phosphorylation of rpS6 and p70S6K ( Fig. 7 F and G)."
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"Mechanistically, MEL specifically inhibited the EGF induced HIF-1alpha expression by suppressing the phosphorylation of ERK, mTOR and p70S6K."
sparser
"EGF induced a rapid phosphorylation of Akt, tuberin, p70S6K and 4E-BP1 ( xref )."
sparser
"As shown in xref , EGF-induced phosphorylation of mTOR, 4E-BP1, and P70S6K was significantly decreased in SiNUAK1/H1299 cells compared with Scr/H1299 cells."
EGF leads to the phosphorylation of RPS6KB1-S6K. 1 / 1
| 1
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"Phosphorylation of p70 (S6K) was also increased by IGF-1 and glucose, but not by TGF-alpha and EGF, despite upstream PKB activation."
EGF leads to the phosphorylation of RPS6KB1 on T412. 1 / 1
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bel
"TABLE V Survey of cell signaling proteins that show a reaction to EGF ligand stimulation over a 180-min time course - 500ng/mL EGF results"