IndraLab

Statements

AGER increases the amount of SERPINE1. 2 / 2
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reach
"The AGE/RAGE signaling pathway not only promotes inflammation such as TNFα and cell death, but also increases endothelial activation biomarker PAI-1 expression in cultured endothelial cells (He et al., 2003; Gregorio et al., 2018)."
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reach
"Gly LDL actives RAGE and a cascade including H-Ras, Raf-1, NOX, ROS, and HSF-1, and consequently increases the expression of PAI-1 XREF_BIBR - XREF_BIBR."
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Catalytically active AGER increases the amount of SERPINE1. 2 / 2
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bel
"RAGE antibody prevented glyLDL-induced up-regulation of PAI-1 in EC (P < 0.05) (Fig. 1B)."
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bel
"Furthermore, we have previously shown that AGEs inhibited prostacyclin production and induced PAI-1 generation in endothelial cells through an interaction with RAGE (Yamagishi et al., 1998; Yamagishi et al., 1996)."
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