IndraLab

Statements

EDN1 activates EGFR. 10 / 35
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"The EGFR is activated by endothelin-1 in asthmatic airway smooth muscle cells and is involved in airway remodeling in asthma ( xref )."
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"ET-1 addition to ovarian cancer cells increased EGFR transactivation and ovarian cancer cellular proliferation which was inhibited by ZD4054 or gefitinib [XREF_BIBR]."
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"Among downstream events after endothelin receptor activation, ET-1 causes EGF receptor transactivation, which is partly responsible for MAPK activation [XREF_BIBR, XREF_BIBR]."
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"ZD4054 was able to reduce the ET-1-induced EGFR transactivation."
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"Activation of MAPK members was detected following stimulation of cells with transforming growth factor α (TNFα) [12] , as well as through epidermal growth factor receptor activation by EGF (13,14) o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"EGFR transactivation caused by addition of ET-1 is dependent on generation of ROS, which may reduce essential disulfide bonds impairing phosphotyrosine."
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"Although the ET (A) receptor subtype is not involved in the early activation of MMPs in type 2 diabetes, ET-1 contributes to transactivation of growth promoting and profibrotic EGFR."
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"In HEY and OVCA 433 ovarian carcinoma cells, ET-1 or EGF induced rapid activation of EGFR, p42/44 mitogen activated protein kinase (MAPK), and AKT."
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"The results indicate that the ET A R regulates cytosolic Ca 2+ in NSCLC cells.The ability of ET-1 to cause transactivation of the EGFR was investigated using NSCLC cells."
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"Additionally, ET-1 can stimulate transactivation of EGFR via ET A receptors in rat cardiac fibroblasts [XREF_BIBR]."
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EDN1 activates EGFR. 3 / 3
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"Modified assertion"
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"Besides being activated by ligand binding, the EGFR can be transactivated by a growing number of different pathways, including G-protein-coupled receptors (GPCRs), cytokine receptors, ion channels, integrins, and other RTKs.37"
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"Treatment of cells with GPCR agonists such as endothelin- 1 (ET-1), thrombin, bombesin, and lysophosphatidic acid (LPA) transactivates ErbB1 (reviewed by Zwick et al. [48]). Mechanistically, the process involves rapid stimulation of metalloproteinases followed by cleavage of an ErbB1 ligand precursor, e.g., pro-HB-EGF [49], whose binding activates ErbB1 and downstream signaling pathways"
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