A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

Modified DUSP6 leads to the phosphorylation of MAPK1. 2 / 2
| 2
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"This reduced expression is associated with constitutive activation of MAPK1 and ERK2 and, despite the presence of mutated KRAS, exogenous overexpression of DUSP6 induces dephosphorylation of MAPK1 and ERK2, subsequent suppression of proliferation, and eventual apoptosis of pancreatic cancer cells."
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"Co-expression of DUSP6 abrogated phosphorylation of wild-type ERK2, kinase impaired ERK2 (ERK2 K54R), ERK2 R191H and endogenous ERK2 (XREF_FIG)."
Phosphatase-active DUSP6 leads to the phosphorylation of MAPK1 on tyrosine. 1 / 1
1 |
bel
"Eleven different protein phosphatases, many previously suggested to be involved in ERK2 regulation, were compared, including tyrosine-specific phosphatases (PTP1B, CD45, and HePTP), dual specificity MAPK phosphatases (VHR, MKP3, and MKP5), and Ser/Thr protein phosphatases (PP1, PP2A, PP2B, PP2C alpha, and lambda PP). The results provide biochemical evidence that protein phosphatases display exquisite specificity in their substrate recognition and implicate HePTP, MKP3, and PP2A as ERK2 phosphatases. The results provide biochemical evidence that protein phosphatases display exquisite specificity in their substrate recognition and implicate HePTP, MKP3, and PP2A as ERK2 phosphatases. "
DUSP6 leads to the phosphorylation of MAPK1. 1 / 1
| 1
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"33 MKP3 attenuates the FGF cascade by dephosphorylating ERK1 and ERK2, molecules important for MAPK downstream signaling."
Modified DUSP6 leads to the phosphorylation of MAPK1-R191H. 1 / 1
| 1
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"Co-expression of DUSP6 abrogated phosphorylation of wild-type ERK2, kinase impaired ERK2 (ERK2 K54R), ERK2 R191H and endogenous ERK2 (XREF_FIG)."