IndraLab

Statements

AKT1S1 inhibits RPS6KB1. 8 / 9
| 8
reach
"PRAS40 inhibits mTORC1 activity by associating with Raptor and can competitively inhibit the binding of mTORC1 substrates p70S6K and 4EBP1 to Raptor (XREF_FIG)."
22980037
reach
"In contrast, PRAS40 can competitively inhibit the binding of the mTORC1 substrates p70S6K and 4EBP1 to Raptor."
22545721
reach
"In addition, PRAS40 blocks mTORC1 activity by preventing the association of p70S6K and 4EBP1 with Raptor."
27488211
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"PRAS40 is an inhibitory protein and can block the binding of the mTORC1 substrates p70S6K and 4EBP1 to Raptor."
22924465
reach
"In addition, the mTORC1 and S6K1 activation caused by the PRAS40 knockdown should trigger feedback inhibition of PI3K and Akt signaling, which will suppress rheb and thus limit mTORC1 activation."
17386266
reach
"PRAS40 also blocks mTORC1 activity by preventing the association of p70 ribosomal S6 kinase (p70S6K) and the eukaryotic initiation factor 4E (eIF4E)-binding protein 1 (4EBP1) with Raptor [XREF_BIBR, XREF_BIBR]."
31794280
reach
"PRAS40 blocks mTORC1 activity by preventing the association of p70 ribosomal S6 kinase (p70S6K) and the eukaryotic initiation factor 4E (eIF4E)-binding protein 1 (4EBP1) with Raptor (Maiese, 2014b; Malla et al., 2015b)."
27127460
reach
"In addition, PRAS40 can block the binding of the mTORC1 substrates p70S6K and 4EBP1 to Raptor."
22732551
AKT1S1 inhibits RPS6KB1. 1 / 1
1 |
bel
"PRAS40 inhibits cell growth, S6K1 phosphorylation, and rheb-induced activation of the mTORC1 pathway, and in vitro it prevents the great increase in mTORC1 kinase activity induced by rheb1-GTP."
17386266