A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

| 6
reach
"In addition, PRAS40 blocks mTORC1 activity by preventing the association of p70S6K and 4EBP1 with Raptor."
reach
"PRAS40 inhibits mTORC1 activity by associating with Raptor and can competitively inhibit the binding of mTORC1 substrates p70S6K and 4EBP1 to Raptor (XREF_FIG)."
reach
"PRAS40 is an inhibitory protein and can block the binding of the mTORC1 substrates p70S6K and 4EBP1 to Raptor."
reach
"PRAS40 blocks mTORC1 activity by preventing the association of p70 ribosomal S6 kinase (p70S6K) and the eukaryotic initiation factor 4E (eIF4E)-binding protein 1 (4EBP1) with Raptor (Maiese, 2014b; Malla et al., 2015b)."
reach
"In contrast, PRAS40 can competitively inhibit the binding of the mTORC1 substrates p70S6K and 4EBP1 to Raptor."
reach
"In addition, PRAS40 can block the binding of the mTORC1 substrates p70S6K and 4EBP1 to Raptor."
1 |
bel
"PRAS40 inhibits cell growth, S6K1 phosphorylation, and rheb-induced activation of the mTORC1 pathway, and in vitro it prevents the great increase in mTORC1 kinase activity induced by rheb1-GTP."