A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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"beta-Catenin is phosphorylated at Ser 552 and Ser 675 by protein kinase A (PKA), protein kinase B (Akt) and AMPK, which enhances beta-catenin contents and mobilization from the cytoskeleton pool."
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"Consistent with LEF1 being a downstream effector of Wnt signaling, aspirin, but not I3C, downregulated protein levels of the Wnt co-receptor LDL receptor related protein-6 and beta-catenin and upregulated the beta-catenin destruction complex component Axin."
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"Our results further demonstrated that silencing of SNHG1 inhibited beta-catenin expression and suppressed the activation level of the WNT and beta-catenin signaling pathway."
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"The total beta-catenin levels were not altered by ExoTG2 compared with controls (XREF_FIG), but significantly increased nuclear beta-catenin in Tgm2-/- MEFs (XREF_FIG)."
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"Whereas GSK3beta phosphorylation of LRP6 activates Wnt signaling [XREF_BIBR], its phosphorylation of beta-catenin inhibits Wnt signaling by targeting beta-catenin for ubiquitin mediated proteosomal degradation [XREF_BIBR]."
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"The instability of beta-catenin caused by increase of p-beta-catenin expression contributes to CD44 mediated inhibition of proliferation."
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"AKT mediated phosphorylation of beta-catenin on Ser 552 promotes nuclear translocation and transcriptional activation of beta-catenin, thereby enhancing metastasis 36."
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"Our results have demonstrated that H. pylori infection upregulates COX-2, which reduces cytoplasmic beta-catenin protein phosphorylation and induces cytoplasmic and nuclear beta-catenin accumulation, thus showing that H. pylori infection can induce the nuclear translocation of beta-catenin."
CTNNB1 bound to TCF_LEF activates CTNNB1. 5 / 5
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"Hence, it has been proposed that while under normoxic conditions beta-catenin binds predominantly to Tcf/Lef and activates classical Wnt and beta-catenin downstream genes, under hypoxic conditions, Hif-1alpha may recruit beta-catenin to alternative binding sites at promoters e.g. promoters that enhance tumor survival [XREF_BIBR]."
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"By interacting with CTNNBIP1, linc00210 blocks the inhibitory role of CTNNBIP1 in Wnt and beta-catenin activation, and enhances the interaction of beta-catenin and TCF and LEF complex, and finally drives Wnt and beta-catenin signaling pathway activation."
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"Linc00210 blocked the inhibitory role of CTNNBIP1, promoted the interaction between beta-catenin and TCF and LEF complex, and finally activated Wnt and beta-catenin signaling."
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"ICAT has been reported to inhibit the interaction between beta-catenin and TCF and impaired the activation of beta-catenin and TCF signaling."
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"CTNNBIP1 interacts with beta-catenin, inhibits the interaction between beta-catenin and TCF and LEF complex, and thus blocks the activation of Wnt and beta-catenin signaling."
Modified CTNNB1 activates CTNNB1. 4 / 4
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"Mutations at APC occur early in CRC and result in increased beta-catenin levels which lead to the expression of Wnt and beta-catenin responsive genes."
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"In the presence of WNT ligands, the beta-catenin destruction complex does not form, beta-catenin escapes ubiquitin-proteasome degradation and translocates to the nucleus to enable transcription of WNT and beta-catenin target genes."
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"Although beta-catenin expression rescues Dnmt1 expression in CTNNB1 KO -HCT116 cells, we did not observe rescue of beta-catenin protein levels in DNMT1 KO -HCT116 cells following expression of Dnmt1 (XREF_FIG)."
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"As shown clearly in the Western analysis of these cells, re-expression of beta-catenin rescues Dnmt1 protein expression in the CTNNB1 -/- cells, indicating the dependence of Dnmt1 protein levels on beta-catenin, although in the reciprocal experiment (XREF_FIG) in which Dnmt1 was expressed in DNMT1 KO -HCT116 cells, significant restoration of beta-catenin protein levels was not observed."
CTNNB1 bound to TCF4 activates CTNNB1. 4 / 4
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"Overexpression of AP-2alpha in HEK293, HCT116 or HT29 cells appeared to decrease the association between TCF-4 and beta-catenin and decreased beta-catenin activity."
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"In this study, we have shown that NOL8, a binding protein of beta-catenin, enhanced the interaction between beta-catenin and TCF4, and activated beta-catenin and TCF signaling."
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"The Tcf-4 and beta-catenin transcriptional activity is inhibited by protein Icat (inhibitor of beta-catenin and Tcf-4), which blocks the interaction between beta-catenin and Tcf-4 and thereby antagonizes Wnt signaling [XREF_BIBR]."
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"The mechanism study revealed that TFCP2 interacted beta-catenin, enhanced the interaction between beta-catenin and TCF4, and activated beta-catenin and TCF signaling."
Phosphorylated CTNNB1 activates CTNNB1. 3 / 3
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"The phosphorylated beta-catenin in the beta-catenin destruction complex is polyubiquitinated by beta-transducin repeat containing protein, a component of a ubiquitin ligase complex, targeting beta-catenin for rapid degradation by the proteasome."
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"Since GSK3 is a kinase within the beta-catenin destruction complex, which could phosphorylate Axin bound beta-catenin and the phosphorylated beta-catenin is then ubiquitinated and targeted for rapid destruction by the proteasome, preventing activation of beta-catenin target genes XREF_BIBR, XREF_BIBR, GSK3 can act as a negative regulator of beta-catenin."
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"Hence, non phosphorylated beta-catenin is released from the complex and translocates to the nucleus, which allows beta-catenin to interact with the transcription factors TCF/LEF to transactivate target genes such as c-myc, cyclin D1, and CD44."
CTNNB1 bound to PSEN1 activates CTNNB1. 2 / 2
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"They demonstrated that PSEN1 forms a complex with beta-catenin in vivo that increases beta-catenin stability."
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"Here we show that presenilin-1 forms a complex with beta-catenin in vivo that increases beta-catenin stability."
CTNNB1 bound to MUC1 activates CTNNB1. 2 / 2
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"The MUC1 cytoplasmic domain (CD) binds directly to the Wnt effector, beta-catenin, and colocalizes with beta-catenin in the nucleus;"
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"In contrast, MUC1 has a highly conserved cytoplasmic tail, which binds beta-catenin, a key component of adherens junctions and a regulator of transcription, in a process that is tightly regulated by MUC1 phosphorylation."
CTNNB1 bound to AXIN activates CTNNB1. 2 / 2
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"When the Wnt pathway is not engaged, CK1 and GSK3beta phosphorylate Axin bound beta-catenin to drive beta-catenin to the proteasome for disruption."
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"Specifically, phosphorylation of Axin by CKI and GSK3 increases Axin binding to beta-catenin, allowing the N-terminal region of beta-catenin to be a more efficient substrate of CK1alpha and GSK3."
CTNNB1 activates mutated CTNNB1. 2 / 2
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"Stabilizing mutations of beta-Catenin and increased levels of nuclear beta-Catenin have been reported in castration resistant PCa."
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"Expression of beta-Catenin in Cells Overexpressing Mutant beta-Catenin."
CTNNB1 bound to TCF4E activates CTNNB1. 2 / 2
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"TPA also enhanced the interaction between beta-catenin and TCF4E in a CK1epsilon and delta dependent way, and finally led to activation of the Wnt and beta-catenin pathway."
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"TPA also increased the interaction between beta-catenin and TCF4E in a CK1epsilon and delta dependent way, and finally led to activation of the Wnt and beta-catenin pathway."
CTNNB1 bound to TCF/LEF activates CTNNB1. 2 / 2
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"This leads to the stabilization and accumulation of cytoplasmic beta-catenin, which then enters the nucleus, binds TCF/LEF proteins and leads to the subsequent dissociation of groucho co-repressors, recruitment of the coactivator p300 and activation of beta-catenin target genes XREF_BIBR - XREF_BIBR."
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"Beta-catenin then translocates to the nucleus and interacts with TCF/LEF which stimulates the beta-catenin downstream target genes (PDK, MTC-1, cMyc, cyclin D1, Cox 2, AXIN 2, etc.) [XREF_BIBR - XREF_BIBR]."
CTNNB1 bound to MUC1-C activates CTNNB1. 2 / 2
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"The functional significance of the MUC1-C and beta-catenin interaction is supported by the demonstration that MUC1-C stabilizes beta-catenin by blocking GSK3beta mediated phosphorylation of beta-catenin and thereby its proteosomal degradation."
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"In contrast to the DKK mechanism, MUC1-C binds directly to and stabilizes beta-catenin, and thereby activates WNT and beta-catenin signaling."
CTNNB1 bound to CDK7 activates CTNNB1. 1 / 1
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"Mechanistically, CDK7 interacted with beta-catenin, enhanced the interaction between beta-catenin and TCF4, and activated beta-catenin and TCF signaling."
CTNNB1 bound to KLF5 activates CTNNB1. 1 / 1
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"It is not known whether beta-catenin and KLF5 cooperatively or independently regulate cell proliferation, but KLF5 can physically interact with beta-catenin in COS-1 cells to enhance the nuclear localization and transcriptional activity of beta-catenin [XREF_BIBR]."
CTNNB1 bound to TCF7L2 activates CTNNB1. 1 / 1
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"The active beta-catenin binds with T-cell factor 4 (Tcf4) and activates beta-catenin and Tcf-dependent transcription."
CTNNB1 bound to PBOV1 activates CTNNB1. 1 / 1
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"In this study, we find that PBOV1 binds to beta-catenin to protect it from phosphorylating by GSK-3beta and thus activates Wnt and beta-catenin signaling, which resulted in markedly boosted stemness of HCC."
CTNNB1 bound to DHX32 activates CTNNB1. 1 / 1
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"Binding of DHX32 to beta-catenin prevented beta-catenin from ubiquitination and degradation, and therefore, enhanced the activity of beta-catenin."
CTNNB1 bound to SALL4B isoforms activates CTNNB1. 1 / 1
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"Furthermore, both SALL4A and SALL4B isoforms can bind beta-catenin protein and synergistically activate the Wnt and beta-catenin signaling pathway 65."
CTNNB1 bound to FOXP3 activates CTNNB1. 1 / 1
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"Co-immunoprecipitation results further indicated that FOXP3 could physically interacted with beta-catenin and TCF4 to enhance the functions of beta-catenin and TCF4, inducing transcription of Wnt target genes to promote cell proliferation, invasion and EMT induction."
CTNNB1 bound to it activates CTNNB1. 1 / 1
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"In fact, it was shown that FoxM1can physically interact with beta-catenin and promote beta-catenin nuclear localization and WNT target gene expression 61."
Mutated CTNNB1 activates mutated CTNNB1. 1 / 1
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"We showed that muscle overexpression of the Ctnnb1 mutant without the TAD was unable to rescue the presynaptic deficits of Ctnnb1 mutation, indicating that the transcription regulation is critical for muscle Ctnnb1 to control presynaptic differentiation."
CTNNB1 bound to MUC1-C cytoplasmic domain activates CTNNB1. 1 / 1
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"The MUC1-C cytoplasmic domain binds directly to beta-catenin and thereby attenuates beta-catenin degradation."
CTNNB1 bound to PAK1 activates CTNNB1. 1 / 1
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"PAK1 also interacts with beta-catenin to promote beta-catenin and TCF4 activation in gastric epithelial cells and it phosphorylates beta-catenin at Serine 675, which increases the stability and transcriptional activity of beta-catenin in colon cancer cells XREF_BIBR."
CTNNB1 bound to YWHAZ activates CTNNB1. 1 / 1
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"14-3-3zeta Interacts with beta-Catenin and Activates beta-Catenin-Dependent Promoters in HEK293T cells and Colon Carcinoma cells. "
CTNNB1 bound to FoxM1can activates CTNNB1. 1 / 1
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"In fact, it was shown that FoxM1can physically interact with beta-catenin and promote beta-catenin nuclear localization and WNT target gene expression 61."
CTNNB1 bound to FOXM1 activates CTNNB1. 1 / 1
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"FoxM1 also directly interacts with beta-catenin during glioma tumorigenesis to induce nuclear localization of beta-catenin, a clear indication of canonical Wnt signaling activation [XREF_BIBR]."
CTNNB1 bound to GS26575 activates CTNNB1. 1 / 1
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"Finally, the interaction between the transcription factor Forkhead box M1 and beta-catenin that promotes beta-catenin nuclear localization in tumor cells and maintains GIC self-renewal has been recently described [XREF_BIBR]."
CTNNB1 bound to adenomatous polyposis coli activates CTNNB1. 1 / 1
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"The isomerized beta-catenin could not bind to nuclear adenomatous polyposis coli, which drives beta-catenin out of the nucleus for proteasomal degradation, which consequently increases the retention of beta-catenin in the nucleus and might explain the decrease of beta-catenin ubiquitination."
CTNNB1 bound to USF1 activates CTNNB1. 1 / 1
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"OGT contributes to beta-catenin stabilization [XREF_BIBR, XREF_BIBR] and consequently to the regulation of miR-483-3p by the CTNNB1 and USF1 complex at the E-box element of the miR-483 promoter."
CTNNB1 bound to TFCP2 activates CTNNB1. 1 / 1
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"The mechanism study revealed that TFCP2 interacted beta-catenin, enhanced the interaction between beta-catenin and TCF4, and activated beta-catenin and TCF signaling."
CTNNB1 bound to ANRIL activates CTNNB1. 1 / 1
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"In the present work, we confirm that ANRIL specifically binds to beta-catenin and increases the transcriptional activity of the WNT and beta-catenin pathway."
Tyrosine-phosphorylated CTNNB1 activates CTNNB1. 1 / 1
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"The release of tyrosine phosphorylated beta-catenin and Arm from adherens junctions increases the cytoplasmic pool of beta-catenin and Arm that is readily available, upon receiving a Wnt signal, for translocation to the nucleus, where it regulates transcription [XREF_BIBR, XREF_BIBR]."
CTNNB1 bound to ESR1 activates CTNNB1. 1 / 1
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"estrogen receptor (ER) alpha- and beta-catenin precipitated within the same immunocomplexes, reciprocally enhanced the transactivation of cognate reporter genes, and were reciprocally recruited to cognate response elements in the promoters of endogenous target genes."
CTNNB1 bound to APC activates CTNNB1. 1 / 1
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"Binding of beta-catenin to APC protein has been suggested to increase beta-catenin turnover, thereby decreasing beta-catenin levels."
CTNNB1 bound to BCL9 activates CTNNB1. 1 / 1
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"BCL9 interacts with beta-catenin and enhances Wnt and beta-catenin signaling."
CTNNB1 bound to BCAR4 activates CTNNB1. 1 / 1
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"In sum, BCAR4 associated with beta-catenin to prevent its degradation and then activates Wnt and beta-catenin signaling pathway."
CTNNB1 bound to SOX1 activates CTNNB1. 1 / 1
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"SOX1 interacts with beta-catenin and induces a proteasome independent down-regulation of beta-catenin."
CTNNB1 bound to Dishevelled1-3 activates CTNNB1. 1 / 1
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"Dishevelled1-3 bound to beta-catenin in nucleus, and promoted nuclear complex formation and transcription activity of beta-catenin and TCF."
CTNNB1 bound to SALL4A activates CTNNB1. 1 / 1
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"Furthermore, both SALL4A and SALL4B isoforms can bind beta-catenin protein and synergistically activate the Wnt and beta-catenin signaling pathway 65."
CTNNB1 bound to SR proteins activates CTNNB1. 1 / 1
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"Biochemical experiments indicate that both SR proteins bind to beta-catenin mRNA and enhance beta-catenin synthesis."
CTNNB1 bound to SPN activates CTNNB1. 1 / 1
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"The intracellular domain of CD43 interacts with beta-catenin and causes an upregulation of the beta-catenin target genes c-MYC and CyclinD1."
CTNNB1 bound to EZH2 activates CTNNB1. 1 / 1
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"EZH2 may directly interact with beta-catenin inducing nuclear accumulation and activation of Wnt and beta-catenin signaling."
CTNNB1 bound to GSK3 activates CTNNB1. 1 / 1
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"Typically, beta-catenin is activated either as a result of GSK-3 inactivation (via its phosphorylation by AKT) or by the recruitment of axin, beta-catenin and GSK-3 to a ternary complex of Frizzled, phosphorylated Dishevelled and phosphorylated LRP5/6 at the plasma membrane (Wnt signaling) [XREF_BIBR, XREF_BIBR]."
CTNNB1 bound to LEF1 activates CTNNB1. 1 / 1
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"MALDI-TOF mass spectrometry (MS) identified two CK2 phosphorylation sites (S42, S61) within the amino terminus of hLEF-1, and mutation of these sites reduced binding to beta-catenin in vitro and transactivation in vivo."