IndraLab

Statements

CREBBP inhibits CREBBP. 10 / 14
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"These results indicated that Ser 1382 and Ser 1386 phosphorylation by IKKalpha promotes the interaction of CBP with p65 and thereby decreases the interaction of CBP with p53.In an attempt to know whet[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17434128
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"These results suggest that the loss of the HAT activity of CBP may cause RTS, as the first example of a defect of HAT activity in a human disease."
11331617
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"As little as 5 μM of MG132 was sufficient to inhibit the CBP degradation, and 10 μM was able to restore the CBP level back to the control level (Fig. 9E)."
26773386
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"This is consistent with the observations that the acetylation of KLF13 by PCAF is not required for PCAF to block CBP acetylation of KLF13), and that PCAFHAT is able to block CBP acetylation mediated d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12758070
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"The results suggest that the loss of C-terminal domains of CBP is sufficient to cause RTS."
10797422
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"[XREF_BIBR XREF_BIBR XREF_BIBR] While the role of 16p13.3 deletions and their subsequent disruption of the CREBBP gene have been shown to cause RTS, its role in the development of specific abnormalities such as the cardiac defects is unclear."
26085772
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"CBP phosphorylation was stimulated by metformin both in vitro and in vivo (XREF_FIG), and metformin antagonized wild type CBP in luciferase assays (XREF_FIG)."
19450513
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"Mutation or deletion in the CBP gene severely affects HAT activity of CBP and the ability of CBP to transactivate CREB, indicating that loss of the HAT activity of CBP may cause RTS."
25024406
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"Suppression of endogenous CBP levels by siRNA duplexes targeting the coding region of the CBP gene produced a 62% depletion of CBP compared to the control duplex siScramble (XREF_FIG)."
19631660
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"On the other hand, Nsp1 of PEDV does not interfere IRF3 phosphorylation and nuclear translocation, but interrupts the enhanceosome assembly of IRF3 and CREB-binding protein (CBP) by promoting proteasomal degradation of CBP (Zhang et al., 2016)."
29294448
CREBBP bound to KAT2B and EP300 inhibits CREBBP. 1 / 1
| 1
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"The CBP, p300, and pCAF complex can arrest cell cycle progression and E1A targets CBP and p300 and drives cell into S phase to cause tumors."
24253305
CREBBP bound to small molecule ICG-001 inhibits CREBBP. 1 / 1
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"The small molecule ICG-001 binds CREB binding protein (CBP) to disrupt its interaction with beta-catenin and inhibit CBP function as a co-activator of Wnt and beta-catenin-mediated transcription."
25082960
CREBBP bound to KAT2B inhibits CREBBP. 1 / 1
| 1
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"These results indicate that E1A and large T antigen dissociate PCAF and p300 and CBP from MyoD without altering MyoD binding to DNA.Consistent with previous observations that transiently expressed E1A[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9659901
CREBBP bound to ICG-001 inhibits CREBBP. 1 / 1
| 1
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"ICG-001, a small molecule, binds CREB binding protein (CBP) to disrupt its interaction with beta-catenin and inhibits CBP function as a co-activator of Wnt and beta-catenin-mediated transcription."
28893318
CREBBP bound to RPS6KA3 inhibits CREBBP. 1 / 1
1 |
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"CBP and RSK2 are associated in a complex in quiescent cells and that they dissociate within a few minutes upon mitogenic stimulus. CBP preferentially interacts with unphosphorylated RSK2 in a complex where both RSK2 kinase activity and CBP acetylase activity are inhibited. Dissociation is dependent on phosphorylation of RSK2 on Ser227 and results in stimulation of both kinase and HAT activities"
11564891
CREBBP bound to MDM2 inhibits CREBBP. 1 / 1
| 1
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"On the other hand, CBP binding to Mdm2 was proposed to reduce the availability of CBP for p53 interaction, resulting in reduced transcriptional activity of p53 [18]."
15013777