IndraLab

Statements

GRWD1 inhibits TP53. 10 / 12
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"A recent study showed that GRWD1 could also inhibit p53 by directly binding to its DNA binding domain."
33688204
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"Conversely, GRWD1 co-expression suppressed several p53 regulated promoters."
31545368
eidos
"A recent study showed that GRWD1 could also inhibit p53 by directly binding to its DNA-binding domain ."
33688204
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"Silencing of GRWD1 increases p53 induction by nucleolar stress, whereas overexpression of GRWD1 reduces p53 induction."
27856536
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"GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis."
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"Our previous analysis showed that GRWD1 negatively regulates the tumor suppressor p53 via the RPL11-MDM2-p53 and RPL23-MDM2-p53 axes."
31545368
sparser
"A recent study showed that GRWD1 could also inhibit p53 by directly binding to its DNA-binding domain."
33688204
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"When overexpressed, GRWD1 suppresses p53 and transforms normal human cells, probably by binding to RPL11 and sequestrating it from MDM2."
28722511
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"Conversely, GRWD1 co-expression suppressed several p53 regulated promoters."
32193559
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"Our previous analysis showed that GRWD1 negatively regulates the tumour suppressor p53 via the RPL11-MDM2-p53 and RPL23-MDM2-p53 axes."
32193559
GRWD1 bound to TP53 inhibits TP53. 2 / 2
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"GRWD1 directly interacts with p53 and negatively regulates p53 transcriptional activity."
32193559
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"GRWD1 directly interacts with p53 and negatively regulates p53 transcriptional activity."
31545368