A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

CDK4 inhibits RB1. 10 / 70
5 | 20 36
reach
"By contrast, assessment of the CDK4 and cyclin D1 complex and measurement of its kinase activity are entirely congruent with the proliferative response, and suggest that CDK4 compensated for diminished CDK2 activity to inactivate pRb and promote cell cycle progression (XREF_FIG)."
reach
"Furthermore, Chou and collaborators showed that inhibition of CDK4 with palbociclib significantly induces apoptosis in pancreatic tumour overexpressing Rb and also enhances the apoptotic effect of chemotherapeutic gemcitabine in patient derived xenografts in mice."
signor
"Phosphorylated by cdk6 and cdk4, and subsequently by cdk2 at ser-567 in g1, thereby releasing e2f1 which is then able to activate cell growth. Here we show that although these cdks phosphorylate multiple residues in prb, they do so with different residue selectivities in vitro;thr821 and thr826 are preferentially phosphorylated by cdk6 and cdk4, respectively."
reach
"Cyclin D1 and Cdk4 complex inhibits Rb by partial phosphorylation, decreasing its association with E2F transcription factor and allowing E2F regulated activation of downstream gene transcription [XREF_BIBR, XREF_BIBR]."
reach
"Furthermore, the p16 INK4a -driven inhibition of CDK4 and CDK6 promotes changes in cell morphology independent of Rb, suggesting additional kinase targets may contribute to the activity of p16 INK4a."
reach
"We confirmed that CDK4 siRNA efficiently abolished p-Rb as well as CDK4 mRNA and protein expression (XREF_FIG)."
reach
"The cyclin D1 and CDK4 complex inactivates Rb to promote G1/S transition and cell proliferation."
sparser
"CDK4 inhibits RB1, and CDKN2B inhibits CDK4 in the RB signaling pathway."
signor
"Cyclin d1 is known to activate cdk4, which then phosphorylates the rb protein, leading to cell cycle progression."
reach
"The MDM2 gene product binds and inactivates p53 protein, whereas the CDK4 gene product is a cyclin dependent kinase and possibly inactivates Rb function."
Kinase-active CDK4 inhibits RB1. 2 / 2
2 |
bel
"\"progression through G1 phase of cell cycle requires phosphorylation of the retinoblastoma gene product (pRb) by the cyclin D-dependent serine-threonine kinases CDK4 and CDK6"
bel
"expression of CDK4/cyclin D1, which stimulated RB phosphorylation"
CDK4 bound to SERTAD1 inhibits RB1. 1 / 1
| 1
reach
"TRIP-Br1 directly binds to Cdk4 and inhibits the activities of p16 and finally Rb [XREF_BIBR]."
CDK4 bound to CYCD1-1 inhibits RB1. 1 / 1
| 1
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"It has been reported that the cyclinD1 and CDK4 complex promotes passage through the G1 phase by inhibiting the retinoblastoma protein XREF_BIBR."
CDK4 bound to Cyclin inhibits RB1. 1 / 1
| 1
reach
"Cyclin D1, a gene with established oncogenic activity, binds and activates cyclin dependent kinases CDK2 and CDK4, which in turn phosphorylate and inactivate Rb allowing entry into S phase of the cell cycle and proliferation."
CDK4 bound to CCND1 and CCND2 inhibits RB1. 1 / 1
| 1
reach
"However, as RB1 activity is blocked by phosphorylation by the CCND1, CCND2, and CDK4 complex, RB1 function will likely decrease to the benefit of E2F complex activity."
CDK4 bound to CCND1 inhibits RB1. 1 / 1
| 1
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"pRb, which controls the G1-S checkpoint of the cell cycle, was inhibited by the CCND1 and CDK4 complex in the promotion of passage via the G1 phase."
CDK4 bound to PSMD10 inhibits RB1. 1 / 1
| 1
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"Gankyrin also binds to CDK4 and the tumor suppressor RB, and accelerates phosphorylation and proteasomal degradation of RB."