IndraLab

Statements

ACVR2A activates SMAD2. 5 / 6
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"Activin performs its function through Acvr2a, which is required for binding Activin to cause downstream p-SMAD2 activation, thus initiating Activin signaling."
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"Two subunits of Inhba form the homodimer Activin A, which signals through canonical ALK4-ACVR2 receptor complexes activating the transcription factors SMAD2 and SMAD3."
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"(A) Endogenous ActRII signaling via phosphorylation (P) of Smad2 and Smad3."
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"In ACVR2A/B dKO parental cells, only ACVR2A , but not ACVR2A , could rescue both pSMAD2 and pSMAD1/5 (Fig 4B)."
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"Similarly, in ACVR2A/B dKO HOM1 cells, ACVR2A could restore both pSMAD2 and pSMAD1/5."
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Kinase-active ACVR2A activates SMAD2. 1 / 1
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"Western blotting revealed higher expression of phosphorylated SMAD2 in wt-ACVR2 transfectants versus controls, suggesting cells deficient in ACVR2 had impaired SMAD signaling."
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