IndraLab

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ANGPTL4 inhibits angiogenesis. 10 / 27
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"However, several studies have claimed that ANGPTL4 inhibits vascular angiogenesis and prevents tumor metastasis in melanoma B16F0, lung cancer 3LL [XREF_BIBR] and colon cancer CMT93 [XREF_BIBR] xenograft mouse models; however, contrasting results were observed in breast cancer [XREF_BIBR], renal cell carcinoma [XREF_BIBR], and ovarian cancer [XREF_BIBR, XREF_BIBR] xenograft models, indicating that ANGPTL4 may act as a tissue specific and multifunctional vascular modulator."
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"Decreased ANGPTL4 impairs endometrial angiogenesis during peri-implantation period in patients with recurrent implantation failure."
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"By contrast, in melanoma, lung, and colorectal cancer, ANGPTL4 inhibits cell growth and angiogenesis [13]."
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"On the other hand, several studies showed that increased ANGPTL4 expression could inhibit tumor growth, metastasis, and angiogenesis in melanoma, lung, and colorectal cancers [XREF_BIBR, XREF_BIBR]."
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"Various studies have also shown that ANGPTL4 expression prevents metastasis and angiogenesis by reducing vascular leakiness, cell motility and invasiveness in different neoplasm types, including melanoma, gastric, lung and colorectal tumors, as well as metastases [XREF_BIBR - XREF_BIBR]."
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"This suggested ANGPTL4 can suppress angiogenesis of HCC."
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"Collectively, these observations support a possible role for ANGPTL4 in the promotion of metastasis in UM and provide a foundation for future studies to determine whether combined inhibition of both ANGPTL4 and VEGF could simultaneously target tumor induced angiogenesis and metastasis, and thereby provide more effective therapies for patients with primary and metastatic UM."
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"It has been reported that the C-terminal domain of ANGPTL4 protein inhibits vascular epithelial growth factor (VEGF) and basic fibroblast growth factor (bFGF)-mediated angiogenesis [XREF_BIBR], and SNP rs1044250 is capable of altering the activity of ANGPTL4 C-terminus, therefore, the SNP rs1044250 may lead to a decreased angiogenesis and dysfunctional endothelial repairment."
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"In vivo, ANGPTL4 inhibits angiogenesis and vascular leakiness as well as melanoma cell motility and invasiveness to prevent metastasis."
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"By knocking-out ANGPTL4 using TALENs method, osteoclastogenesis, osteolysis and angiogenesis induced by GCTSCs were significantly suppressed in vitro."
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ANGPTL4 inhibits angiogenesis. 1 / 1
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"Here, we identify ARP4/fasting-induced adipose factor/peroxisome proliferator-activated receptor gamma angiopoietin-related as a novel antiangiogenic modulatory factor."
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