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IndraLab

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

CCND1 phosphorylates RB1. 9 / 88
| 3 67 12
sparser
"Both cyclin D1-CDK4/6 and cyclin E-CDK 2 are capable of phosphorylating Rb, however neither is sufficient to hyperphosphorylate and in turn inactivate Rb."
sparser
"Western-blot analysis shows that cyclin D1 and phosphorylated retinoblastoma protein were significantly lower in HF/C offspring than in C/C offspring."
sparser
"The Rb protein inhibits entry into the cell-division cycle when it is unphosphorylated and, conversely, phosphorylation of Rb by the complex of CDK4 and cyclin D1 encourages cell proliferation."
sparser
"A previous study has suggested that cyclin D1-CDK4 phosphorylates Rb in vivo [ xref ]."
reach
"CCND1, in association with cyclin dependent kinase (CDK4 and CDK6), phosphorylates the Rb, blocking its growth inhibitory activity, promoting cells to pass through the R point and thus driving them from G1 phase to S phase."
reach
"CCND1 and Cyclin Dependent Kinase (CDK) 4-6 complexes initiate the phosphorylation of pRb and cyclin E and CDK2 complex completes the procedure in late G1 phase."
sparser
"It is well known that the cyclin D1-CDK4 complex and the cyclin E-CDK2 complex hyperphosphorylate pRb during the G1-S transition [ xref ]."
reach
"The phosphorylation of RB1 by CCND1 and CDK4 prevents cell cycle arrest at the G1/S start point."
sparser
"The activated cyclin D1-CDK4/6 complex phosphorylates Rb protein, and subsequently induces the expression of E2F-target genes that are necessary for DNA synthesis ( xref )."
CCND1 phosphorylates RB1 on S780. 4 / 5
| 4
sparser
"The cyclin D1-CDK4/6 complex specifically phosphorylates Rb at Ser 780 [ xref ]."
sparser
"The RB Ser 807/811 phosphorylation by cyclin E-CDK2 requires RB Ser 780 phosphorylation by cyclin D1-CDK4/6 [ xref ]."
sparser
"The active cyclin D1-CDK4 complex phosphorylates the Rb protein at Ser780, which results in the release of the E2F transcription factor from the Rb-E2F complex."
sparser
"Thus, the dual role of Rb in regulating cell proliferation and differentiation is mediated by its phosphorylation status. xref Both cyclin D1-CDK4 and cyclin E-CDK2 phosphorylate Rb during the G1/S cell cycle progression, and cyclin D1-CDK4 specifically phosphorylates Rb at Serine 780 in vitro in human fibroblasts. xref We previously reported that sepsis inhibits cyclin-dependent kinase inhibitor p21 expression due to increases in the NFI-A protein. xref P21 inhibits the cyclin D1-CDK4 protein complex, which facilitates cell cycle arrest and promotes cell differentiation. xref , xref In this study, knockdown of cyclin D1 or CDK4 in sepsis Gr1 + CD11b + cells inhibited Rb phosphorylation at Serine 780 ( xref ), Rb knockdown displaced C/EBPβ from the miR promoters and simultaneously induced C/EBPα binding ( xref ) and abolished the miR promoter-driven reporter gene expression ( xref )."
Modified CCND1 leads to the phosphorylation of RB1. 2 / 2
| 2
reach
"DDT has also been shown to enhance proliferation by increasing the expression of Ccnd1 (cyclin D1)/E2f, inducing phosphorylation of pRb, increasing the expression of p53 degrading protein Mdm2 (a negative regulator of p53) and disrupting gap-junctional intercellular communication."
reach
"These findings indicated that Cdk6 and Ccnd1 overexpression inhibited chondrocyte maturation and enhanced G1/S cell-cycle transition by phosphorylating pRb, but the chondrocytes failed to accomplish the cell cycle, and underwent p53 dependent apoptosis probably due to the dysregulation of E2f target genes."
CCND1 phosphorylates RB1 on T356. 1 / 1
| 1
reach
"In addition, inactivation of the tumor suppressor retinoblastoma 1 (RB1), reflected by CCND1 and CDK6 inactivating phosphorylation of RB1 at T356, inversely correlated with expression of EGFR in patient HNSCC samples."
CCND1 bound to CDK4 phosphorylates RB1 on S795. 1 / 1
1 |
signor
"Cyclin d1 is known to activate cdk4, which then phosphorylates the rb protein, leading to cell cycle progression."
CCND1 bound to CDK4 phosphorylates RB1 on T5. 1 / 1
1 |
signor
"In summary, we have shown evidence that CDK4-cyclin D1 phosphorylates Thr5, Ser249, Thr252, Thr356, Thr373, Ser788, Ser795, Ser807, Ser811, and Thr826 of pRB."
Kinase-active CCND1 bound to CDK4 leads to the phosphorylation of RB1. 1 / 1
1 |
bel
"The primary substrates of CDK4/6 and CDK2 in G1 progression are the members of the retinoblastoma protein family RB,p107 and p130 The activity of the RB proteins is modulated by sequential phosphorylation by CDK4/6cyclinD and CDK2cyclinE complexes"
CCND1 bound to AHR and CDK4 phosphorylates RB1. 1 / 1
| 1
trips
"In vitro assays for CDK4 kinase activity demonstrated that RB1 phosphorylation by the AHR/CDK4/CCND1 complex was reduced in the presence of TCDD."
CCND1 bound to CDK4 phosphorylates RB1 on T356. 1 / 1
1 |
signor
"In summary, we have shown evidence that CDK4-cyclin D1 phosphorylates Thr5, Ser249, Thr252, Thr356, Thr373, Ser788, Ser795, Ser807, Ser811, and Thr826 of pRB."
CCND1 bound to CDK4 phosphorylates RB1 on S780. 1 / 1
1 |
signor
"Cyclin d1 is known to activate cdk4, which then phosphorylates the rb protein, leading to cell cycle progression."
CCND1 bound to CDK4 phosphorylates RB1 on T826. 1 / 1
1 |
signor
"We demonstrate that phosphorylation by either cdk2-cyclin a, which phosphorylates t821, or cdk4-cyclin d1, which phosphorylates threonine 826, can disable prb for subsequent binding of an lxcxe protein."
CCND1 bound to CDK4 phosphorylates RB1 on S788. 1 / 1
1 |
signor
"In summary, we have shown evidence that CDK4-cyclin D1 phosphorylates Thr5, Ser249, Thr252, Thr356, Thr373, Ser788, Ser795, Ser807, Ser811, and Thr826 of pRB."