IndraLab

Statements

CBL decreases the amount of EGFR. 4 / 13
1 | 3
reach
"Increasing evidences show that Cbl negatively regulate the expression of EGFR [XREF_BIBR], therefore, immunolabeling for EGFR was performed on the entire cohort 1 in an effort to determine if the prognostic value of Cbl density was related to EGFR status."
26474280
reach
"We show that silencing Cdc42 significantly reduces protein levels of EGFR, leading to a marked reduction in cell proliferation and migration, and c-Cbl knockdown increases the levels of EGFR."
16585176
reach
"C-Cbl served as an internal control and significantly reduced the total amount of EGFR as previously shown [38]."
18602463
signor
"Ligand binding to EGFR also leads to rapid internalization and proteosomal/lysosomal degradation of the receptors. This process results in a dramatic downregulation of both total and cell surface receptors. EGF-induced degradation of EGFR is thought to be initiated by phosphorylation of tyrosine 1045 of the receptor followed by binding of Cbl adaptor proteins and ubiquitination of the receptor. Internalized EGFR is transported to early endosomes where receptor-ligand complexes are sorted for either degradation or recycling to the cell surface."
20332299
Modified CBL decreases the amount of EGFR. 4 / 4
| 4
reach
"Increasing evidence suggests that loss of Cbl regulated ErbB1 degradation contributes to ErbB1 overexpression in cancer cells."
17288526
reach
"Western blotting with an antibody that detected EGFR phosphorylated on tyrosine 1068 did show that loss of c-Cbl very moderately increased the overall levels of active EGFR before and after EGF stimulation (XREF_FIG)."
21949687
reach
"136 This finding has therapeutic implications as ectopic c-Cbl expression in osteosarcoma cells could reduce the expression of EGFR and PDGFR-alpha, resulting in decreased cell proliferation and survival, and reduced incidence of lung metastasis in mice."
23328670
reach
"Therapeutically, ectopic c-Cbl expression in osteosarcoma cells could reduce the expression of EGFR and PDGFR-alpha, resulting in decreased cell proliferation and survival and reduced lung metastasis [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25285640
CBL bound to EGFR decreases the amount of EGFR. 1 / 1
1 |
bel
"On EGFR activation, c-Cbl associates with phosphorylated Tyr-1045 and ubiquitinates the receptor, marking it for clathrin-mediated endocytosis and recognition by the lysosomal machinery, which results in receptor degradation and signal termination (3–6)."
17971399