IndraLab

Statements

HIPK2 activates JNK. 10 / 19
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"However, SUMO-1 modification inhibited HIPK2 induced JNK activation and p53 independent antiproliferative function."
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"In addition, HIPK2 also activates the apoptotic response independent of p53 by regulating the JNK pathway and by targeting the anti-apoptotic transcriptional repressor CtBP for degradation."
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"RNA interference mediated HIPK2 knockdown inhibits TGF- beta -induced JNK activation [XREF_BIBR], and HIPK2 effect on JNK is modulated through dynamic SUMO-1 modification [XREF_BIBR]."
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"Hofmann et al. [XREF_BIBR] have demonstrated that SUMO protease SuPr-1 interacts with HIPK2 and deconjugates SUMO from HIPK2, thereby antagonizing the inhibitory effect of SUMO-1 on HIPK2 mediated JNK activation."
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"19 However, the role of HIPK2 activation in JNK activation upon glucose restriction needs to be further elucidated because several signaling kinases may regulate survival during glu stv."
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"Previous reports showed that HIPK2 can signal cell death via p53, and independently of p53 by activating the c-Jun NH2-terminal kinase (JNK) pathway or mediating CtBP degradation."
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"Interestingly, loss of HIPK2 selectively blocks JNK activation without affecting Xbp1 splicing or the activation of IRE1alpha and ASK1 (XREF_FIG)."
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"HIPK2 with a mutated SUMO acceptor lysine residue was refractory to inhibition of HIPK2 mediated JNK activation by SUMO-1."
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"To investigate whether HIPK2 activation might contribute to the pathogenesis of ALS caused by SOD1 mutations, we asked if loss of HIPK2 could block JNK activation in SOD1 G93A mice."
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"Subsequently, homeodomain-interacting protein kinase 2 (HIPK2), involved in transcriptional regulation and apoptosis, was shown to activate JNK via DAXX and the mitogen-activated protein kinase kinases MKK4 (MAP2K4) and MKK7 (MAP2K7)."
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Kinase-active HIPK2 activates JNK. 1 / 1
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"SUMO-1 modification inhibited HIPK2-induced JNK activation and p53-independent antiproliferative function"
15958389