IndraLab

Statements

TXN inhibits MAP3K5. 10 / 94
| 2 71 15
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"TRX inhibits ASK1 by physical binding ( xref )."
18783313
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"Our data demonstrates the inhibition of the inherited programmed cell death of photoreceptors in the tubby retina by overexpression of Trx; the reduction in the activation of ASK1 and JNK in the photoreceptors of tub and Trx mice compared with Tubby."
20298786
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"Trx can also bind and inhibit apoptosis signal-regulating kinase 1 ( xref ), an upstream kinase in the cellular stress–sensitive pathways (i.e., JNK and p38 pathways)."
19592618
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"Namely, reduced Trx inhibits the function of ASK1, thus preventing apoptosis (Saitoh et al., 1998)."
33134322
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"Conversely, miR-98 and let-7b has been demonstrated to mediate the anti-hypertrophic effect of thioredoxin (Trx1), an ubiquitously expressed antioxidant that inhibits NF-kappaB (nuclear factor kappa-light-chain enhancher of activated B cells), Ras and ASK1 (apoptosis signal regulating kinase 1)."
24113581
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"Furthermore, it functions as an anti-apoptotic factor because Trx inhibits apoptosis signal regulating kinase 1 (ASK1), a critical factor involved in stress induced cell death (Saitoh et al. 1998)."
20619274
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"Trx, which inactivates ASK1 by directly binding to the kinase, itself has catalytic redox activity in a wide variety of intracellular molecular processes."
25068797
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"Alternatively, induction of Trx by cytokines such as IFN-gamma, or oxidative or radiation stresses, blocks ASK1 activation and protects cells against apoptosis."
23106210
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"Trx is known to inhibit the kinase activity of ASK1 by directly interacting with the N-terminal region of ASK1 (Saitoh et al. 1998)."
20619274
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"Moreover, the loss of TXN activity will allow ASK1 to be more readily activated [XREF_BIBR - XREF_BIBR]."
26122708
TXN bound to MAP3K5 inhibits MAP3K5. 3 / 3
| 3
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"Trx1 and 14-3-3 bind to ASK1 and inhibit ASK1 activity."
28435845
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"DFO- and Dp44mT induced JNK activation was found to be mediated by Trx oxidation following iron chelation, causing dissociation of the ASK1 and Trx complex that normally inhibits ASK1 kinase activity and subsequent ASK1 dependent apoptosis [XREF_BIBR, XREF_BIBR]."
26125440
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"Trx1 directly interact with ASK1, a pro apoptotic kinase, thereby inhibiting the kinase activity of ASK1 independently of cysteine modification."
22904041
TXN inhibits MAP3K5. 2 / 2
2 |
bel
"Apoptosis signal-regulating kinase-1 (MAP3K5) is held in an inactive conformation by thioredoxin and when oxidized by ROS, this triggers the apoptotic pathway."
15602009
bel
"Redox-sensing molecules such as thioredoxin (TRX) and glutaredoxin (GRX) bind to apoptosis signal-regulating kinase 1 (ASK1) and suppress its activation"
12723971