A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

| 3 4 787
reach
"Overexpression of p53 can not only trigger the apoptotic process, but can also inhibit cell cycle progression from the G1 phase to the S phase."
reach
"Constitutive activation of MEK in IECs can produce either premature senescence or forced mitogenesis depending on the integrity of a senescence program controlled by the cell cycle inhibitors p53, p16 (INK4A), and p21 (CIP)."
reach
"When an endogenous or exogenous stress occurs, p53 levels increase and lead to block cell cycle, allowing the DNA-repair."
reach
"Aberration expression of miR-34 impairs p53 mediated cell cycle arrest and apoptosis."
reach
"Transient or irreversible p53 mediated cell cycle arrest in the transition from the G1 to S phase of cell replication is mediated by the transcriptional activation of the cyclin dependent kinase (CDK) inhibitors such as p16 and p21."
reach
"In addition, overexpression of PTC1 inhibited the phosphorylation level of p53 by ATM and caused G (1)/S phase arrest of cell cycle."
trips
"Abnormalities in G1/S transition in cell cultures have been attributed to alterations in ErbB (erythroblastic leukaemia viral [v-erb-b] oncogene homologue, avian) signalling, cyclin D1 overexpression or disturbance of the p21(WAF1) (p21)-mediated cell cycle arrest induced by p53."
reach
"Therefore, under well defined cellular circumstances, these studies demonstrate that p53 can mediate a reversible cell cycle arrest in response to DNA damage with doxorubicin."
reach
"XREF_BIBR In colorectal cancer cells (HCT116 cells and HT29 cells), it has been shown that TSA induces G2/M cell cycle arrest and bax dependent apoptosis by both p53 dependent and -independent mechanisms."
Mutated TP53 inhibits cell cycle. 10 / 20
| 20
reach
"Our study indicated that knockdown of mutant p53 by siRNA was able to induce G2-phase cell cycle arrest and apoptosis in 5637 and T24 human bladder cancer cells."
reach
"Also, silencing of mutant p53 in 5637 (p53 R280T) and T24 (in-frame deletion of Y126) bladder cancer cell lines by p53 siRNA induces G2 arrest of the cell cycle and apoptosis, and increases sensitivity to cisplatin."
reach
"Mutation of p53 on serine 18 impairs the ability of AMPK to induce cell cycle arrest [XREF_BIBR]."
reach
"There is a rationale to consider p53 as a putative prognostic factor of lung cancer : From a theoretical point of view, the p53 mutation resulting in an inactive protein leads to lack of control of cell proliferation by inhibiting the cell cycle arrest in the Gap 1 phase."
reach
"Since cell cycle control is directly or indirectly disrupted by TP53 mutations in tumor cells, the overlapping functions in BRmet50 and PMID18271932Sig33 may represent gene expression alterations resulting from the loss of TP53 [XREF_BIBR]."
reach
"These mouse models suggest p53 mutation disrupts cell cycle checkpoint control and DNA damage signaling, and, in the absence of telomerase, permits tumor progression, likely through activation of ALT."
reach
"Silencing of mutant p53 by siRNA induces cell cycle arrest and apoptosis in human bladder cancer cells."
reach
"Considering that the lower proliferation rate and the slight decrease in the amounts of phospho-histone H3 at Ser 10 in mutant p53 knockdown Panc-1 cells, it is suggestive that knockdown of mutant p53 alone might induce cell cycle arrest before the initiation and/or after the termination of mitosis."
reach
"Mouse models have shown that TP53 mutation disrupts cell cycle checkpoint control and DNA damage signaling [XREF_BIBR, XREF_BIBR]."
reach
"Mutant p53 was experimentally demonstrated to deregulate checkpoints of cell cycle responses to the induction of DNA damage, which accelerated tumour progression via the promotion of genomic instability, cell proliferation and invasion [XREF_BIBR, XREF_BIBR]."
Transcriptionally active TP53 inhibits cell cycle. 6 / 6
6 |
bel
"N:-phosphoacetyl-L-aspartate (PALA) and gamma-radiation induce reversible and irreversible p53-mediated G(1) cell cycle arrest, respectively."
bel
"Not Available"
bel
"Most strikingly, upon cell cycle arrest resulting from genotoxic stress and p53 activation, TFII-I is ubiquitinated and targeted for proteasomal degradation in a p53- and ATM (ataxia telangiectasia mutated)-dependent manner."
bel
"The activation of tumor suppressor p53 induces apoptosis or cell cycle arrest depending on the state and type of cell, but it is not fully understood how these different responses are regulated."
bel
"together to form a ternary complex. We show that, when overexpressed, L23 inhibits HDM2-induced p53 polyubiquitination and degradation and causes a p53-dependent cell cycle arrest."
bel
"Substitution of Thr-55 with an alanine residue (T55A) stabilizes p53 and impairs the ability of TAF1 to induce G1 progression."
TP53 bound to MDM2 inhibits cell cycle. 2 / 2
| 2
reach
"Both HDM2 and HDMX bind to p53 and prevent cell cycle arrest or apoptosis in damaged cells."
reach
"The TP53 function is controlled by MDM2, which binds to TP53 and prevents TP53 dependent cell cycle arrest or apoptosis XREF_BIBR."
TP53 bound to ATG7 inhibits cell cycle. 1 / 1
| 1
reach
"While cleaved Atg5 promotes cytochrome c release and apoptosis, full-length Atg7 binds to p53 to prevent p53 dependent cell cycle and cell death."
Ubiquitinated TP53 inhibits cell cycle. 1 / 1
| 1
reach
"Degradation of ubiquitinated p53 allows the progression of the cell cycle in the presence of DNA damage and the turnover of p53 by E6-AP mediated ubiquitination affects growth in oncogenic HPV infected cells."
TP53 bound to E6 inhibits cell cycle. 1 / 1
| 1
reach
"Proteins E6 and E7 interact with p53 and retinoblastoma protein, respectively, to deregulate the cell cycle and promote division."
TP53 bound to RUNX2 inhibits cell cycle. 1 / 1
| 1
reach
"The p21Cip1 cell cycle regulator can be suppressed by the p53 and RUNX2 complex [XREF_BIBR]."
TP53 bound to ESR1 inhibits cell cycle. 1 / 1
| 1
reach
"There are at least two potential avenues that MCF-7 cells can use to escape from the constraints of p14ARF-p53 induced senescence based on the literature : cyclin D1 can bind to the estrogen receptor (ER) independent from cdk4/6 and stimulate proliferation XREF_BIBR, XREF_BIBR, XREF_BIBR; ER can bind to p53 and abrogate cell cycle arrest XREF_BIBR, XREF_BIBR, XREF_BIBR."
TP53 inhibits cell cycle. 1 / 1
1 |
bel
"These data suggest that androgen withdrawal results in a cell stress response, in which increased p53 protein produces a cell cycle arrest, without activation of p53-mediated apoptosis."
Modified TP53 inhibits cell cycle. 1 / 1
| 1
reach
"Loss of p53 attenuated DeltaNp73alpha expression and partially restored cell cycle arrest while loss of p73 lead to loss of DeltaNp73alpha and consequently to high levels of p21 expression and cell cycle arrest after UV exposure."
TP53 bound to HDMX inhibits cell cycle. 1 / 1
| 1
reach
"Both HDM2 and HDMX bind to p53 and prevent cell cycle arrest or apoptosis in damaged cells."
TP53-V143A inhibits cell cycle. 1 / 1
| 1
reach
"Even though we observed an accelerated cell cycle progression of control cells when p53 functions were inhibited, p53 V143A failed to abrogate the Aurora-A-mediated cell cycle stop."
TP53 bound to E7 inhibits cell cycle. 1 / 1
| 1
reach
"Proteins E6 and E7 interact with p53 and retinoblastoma protein, respectively, to deregulate the cell cycle and promote division."