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"Unpredictably, the levels of apoptosis induced by ectopic p53 expression were lower than those of the p53 competent cells latently infected with HIV-1."
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"BZLF1 polyubiquitinates and induces the degradation of p53, which inhibits apoptosis and is required for efficient viral propagation in the lytic replication stage [XREF_BIBR, XREF_BIBR]."
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"To investigate any possible role of hGSTA4-4 in the regulation of Fas and p53 mediated apoptosis, we studied the effect of hGSTA4-transfection on the components of these pathways."
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"TFDP3 inhibits E2F1 induced, p53 mediated apoptosis."
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"These results indicate that CA affects both autophagy and apoptosis, partially mediated by p53."
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"PUMA (p53 upregulated modulator of apoptosis) was recently identified a potent proapoptotic molecule."
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"We demonstrate that PUMA is an essential non redundant mediator of p53 induced apoptosis in MPPs but not lymphoid cells in the context of Mysm1 deficiency."
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"p53 did not seem to be involved as a p53 null cell line was sensitive to docetaxel and an inhibitor of p53 did not inhibit apoptosis."
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"In details, in the context of p53-wt, stabilization and activation of p53 induces long-term cell-cycle arrest, apoptosis, or senescence by transcriptionally regulating, among others, the CDK inhibitor p21 and the pro apoptotic protein BAX [XREF_BIBR]."
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"In contrast, Huang et al. found that the knockdown of KDM1 increases the transcriptional activation of p21 and MDM2 by p53, resulting in an increase in p53 mediated apoptosis."
Mutated TP53 activates apoptotic process. 10 / 100
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"Even though a few improvised p53-variants have been discovered mostly in terms of protein stability XREF_BIBR - XREF_BIBR, here we report a new p53 mutant that induces higher apoptosis by directly binding to a specific DNA sequence."
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"For example, mutant p53 3KR can not induce cell-cycle-arrest, senescence, or apoptosis, but it can still regulate metabolic target genes resulting in decreased ROS levels and reduced glycolytic flux."
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"Our result suggests that mutant p53 in U373MG cells can induce apoptosis through a transcription independent pathway, as the level of cytochrome c increased in the cytosolic fraction, whereas the level of cytochrome c decreased in the mitochondrial fraction with a decrease in mitochondrial membrane potential (XREF_FIG)."
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"The cell death was reported to be p53 independent because a p53 mutation failed to rescue the observed apoptosis XREF_BIBR."
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"Inhibition of TAp63 or TAp73 has no effect on apoptosis induced by mutant p53 knockdown (XREF_FIG)."
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"Consistent with this, Caelles and Karin XREF_BIBR found that apoptosis induced by stabilization of an ectopically expressed temperature sensitive mutant of p53 could proceed in the absence of RNA and protein synthesis."
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"However, there is substantial evidence showing that mutant p53 is still able to induce apoptosis through different mechanisms."
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"The apoptosis of cervical squamous carcinoma cells in the group treated with the mutant p53 + gC1qR vector was lower than that in the empty pCB6 vector + gC1qR vector group (p < 0.05)."
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"Mutant p53 skin cancer cell lines were more resistant to IMQ induced apoptosis than wildtype p53 skin cancer cell lines."
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"The homozygous tp53 mutation as well as the tp53 knockdowns rescued retinal apoptosis in 50 hpf flo mutants (n = 25 flo and tp53 double mutants analyzed and> 200 tp53 morpholino injected larvae analyzed; XREF_FIG)."
Modified TP53 activates apoptotic process. 10 / 10
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"Expression of exogenous p53 in wild-type p53 cells did not induce elevation of Bax levels, arrest in G2 phase, or apoptosis."
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"The authors conclude that high levels of p53 prevent Sod2 expression to enhance apoptosis, whereas low levels of p53 may enhance Sod2 levels to promote a pro survival state."
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"Interestingly, over-expression of p53-WT promoted CPT induced PARP-1 degradation and apoptosis, whereas over-expression of p53-S15A or p53-S20A or p53 S46A mutant failed to induce PARP-1 degradation and TUNEL apoptosis after CPT treatment (XREF_FIG and XREF_SUPPLEMENTARY)."
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"Ectopic expression of wild-type p53 induced both p21 expression and apoptosis."
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"DNA damage results in an increase in P53 levels, which is required to initiate a P53 mediated cell cycle arrest and/or apoptosis."
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"Expression of p53 enhances selenite induced superoxide production and apoptosis in human prostate cancer cells."
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"Overexpression of p53 activates transcription of p53 effector genes, causes growth inhibition and induced apoptosis."
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"Ectopic expression of wild-type p53 in WEHI 231 cells induced both p21 expression and apoptosis."
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"Mutant procaspase-1 also inhibited apoptosis induced by p53 overexpression or doxorubicin treatment, which induce caspase-1 gene expression."
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"Nutlin 3a treatment of wild type p53 expressing cultured cancer cells increases p53 levels and causes p53 mediated transactivation, cell cycle arrest, and apoptosis [XREF_BIBR]."
Acetylated TP53 activates apoptotic process. 5 / 5
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"In response to DNA damage, acetylation of p53 is stimulated and acetylated p53 enhances its ability to induce cell-cycle arrest, apoptosis, and DNA damage repair (Smith and La Thangue, 2005)."
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"Low Dose Valproic Acid Enhances Radiosensitivity of Prostate Cancer through Acetylated p53 Dependent Modulation of Mitochondrial Membrane Potential and Apoptosis."
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"The association between these two proteins was acetylation independent, but acetylation of p53 could prevent and disrupt the Ku70 and BAX complex and enhance apoptosis."
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"To further investigate the physiological significance of SET and TAF-Ibeta in acetylated p53 mediated apoptosis, we used the developing Drosophila eye as an in vivo model system."
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"Subsequently, the acetylated p53 promotes apoptosis of cancer cells by transcriptionally activating several pro apoptotic genes such as Noxa and Puma in response to DNA damaging drugs such as DOX [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
TP53 bound to TP53BP2 activates apoptotic process. 4 / 4
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"The in vivo assay demonstrated that EGFR and SOS1 promoted growth of nuclear p-AKT +, Bcl-2 + cells results in the resistance of hepatoma cells to ASPP2 and p53 complex induced apoptosis and that blocking nuclear translocation of EGFR dramatically improves and enhances the pro apoptotic function of ASPP2."
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"The association between low TP53BP2 expression and poor survival in TP53 mutated breast cancer seems counterintuitive at first, because TP53BP2 binds TP53 to induce apoptosis, and this pro apoptotic cooperation can be defective or absent when TP53 is mutated [XREF_BIBR, XREF_BIBR]."
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"Thus, EGFR and SOS1 promoted the growth of nuclear p-AKT +, Bcl-2 + cells results in the resistance of hepatoma cells to ASPP2 and p53 complex induced apoptosis."
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"Upon DNA damage or oncogenic stimuli, ASPP2 binds and activates p53, inducing apoptosis."
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"Moreover, we have previously described that the human Tp53 Arg72Pro single nucleotide polymorphism (SNP) controls susceptibility to ischemia induced neuronal apoptosis and governs the functional outcome of patients after stroke."
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"We also examined the effect of TP53 Arg72Pro polymorphism on irradiation induced apoptosis (IA)."
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"The TP53 Arg72Pro polymorphism alters the ability of the TP53 protein to induce apoptosis versus cell-cycle arrest XREF_BIBR - XREF_BIBR."
TP53-K117R activates apoptotic process. 3 / 3
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"Moreover, to exclude the possibility that the mutant cells die with slower kinetics, we compared the levels of apoptosis induced by DNA damage in p53-wt, p53 K117R and K117R, p53 3KR/3KR and p53-null mice."
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"Analysis of cells derived from p53 K117R mice, carrying the acetylation site mutation that renders p53 defective for triggering apoptosis in cultured cells in vitro, confirmed that p53 K117R could not induce Puma or apoptosis in response to DNA damage, suggesting that acetylation at K117 is critical for p53 dependent apoptosis."
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"Further, p53 K117R; K161R; K162R is mutated at three p53 acetylation sites and can not induce cell cycle arrest, apoptosis, and senescence."
TP53 bound to WWOX activates apoptotic process. 2 / 2
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"The DNA fragmentation significantly increased in the combination compared to p53 or WOX-1 alone expressing cells, suggesting that tumor suppressor p53 physically interacts with WOX1 to induce apoptosis."
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"Physical and functional interactions between WWOX and p53 have previously been reported to promote mitochondrial apoptosis."
Phosphorylated TP53 activates apoptotic process. 2 / 2
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"During infection, the phosphorylated p53 is functionally active to induce apoptosis along with the expression of p21 and mdm2 [XREF_BIBR]."
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"Acute hyperglycemia on healthy platelets induces phosphorylated p53 mediated mild mitochondrial dysfunction and damage, mild ROS increases, and minimal apoptosis, in part due to the protective effects of increased levels of Bcl-X L in normal platelets as compared to DM (Tang etal, 2011, 2014)."
TP53-R172P activates apoptotic process. 2 / 2
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"We used the p53 (R172P) knock-in mouse, which is unable to induce apoptosis but retains intact cell-cycle arrest and cellular senescence pathways, to show that spontaneous tumorigenesis is potently repressed in Terc -/- p53 (R172P) mice."
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"The p53 R172P mutant, which can activate p21 - the major cell cycle regulator transcriptionally activated by p53 - but not apoptosis target genes (Text Box 1) has helped to address this question [XREF_BIBR]."
TP53 bound to PPIF activates apoptotic process. 2 / 2
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"To evaluate the role of p53-CypD following IR-AKI, we tested the hypothesis that the p53 and CypD complex mediates renal tubular cell apoptosis in IR-AKI via mPTP opening."
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"These results suggest that the p53 and CypD complex mediates renal tubular cell apoptosis in IR-AKI via mPTP opening."
TP53 bound to BCL2L1 activates apoptotic process. 1 / 1
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"Mutant Bcl-xL that bound p53, but not PUMA, rendered cells resistant to p53 induced apoptosis irrespective of PUMA expression."
TP53 bound to Its activates apoptotic process. 1 / 1
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"Its interaction with liprin alpha1 and p53 contribute to mitigate cell spreading and induce apoptosis of cancer cells."
TP53 bound to gamma-H2AX activates apoptotic process. 1 / 1
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"In irradiated spermatogonia, gamma-H2AX interacts with p53, which induces spermatogonial apoptosis."
TP53 bound to PATZ1 activates apoptotic process. 1 / 1
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"PATZ1 interacts with p53 and regulates expression of p53-target genes enhancing apoptosis or cell survival based on the cellular context."
TP53-K120R activates apoptotic process. 1 / 1
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"In keeping with this hypothesis, p53 K120R expression in PC-3 cells did not lead to increased apoptosis or loss of MMP following IR when cells were also first treated with VPA (XREF_FIG and XREF_SUPPLEMENTARY)."
TP53 bound to it activates apoptotic process. 1 / 1
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"For example, it has been shown that DAXX interacts with p53 and promotes p53 dependent apoptosis."
TP53 bound to AFG1L activates apoptotic process. 1 / 1
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"LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis."
TP53-R178E activates apoptotic process. 1 / 1
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"Surprisingly, stabilization of p53 R178E in Mdm2 -/- mice nevertheless triggers extensive apoptosis, indicative of residual wild-type activities."
TP53-M214K activates apoptotic process. 1 / 1
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"Homozygous p53 (M214K) mutant embryos (abbreviated as p53 -/-) carrying a loss-of-function p53 point mutation were employed to exclude the contributions of the morpholino induced non specific cell apoptosis."
TP53 bound to NDN activates apoptotic process. 1 / 1
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"Furthermore, necdin binds to the tumor suppressor protein p53 and inhibits p53 dependent apoptosis, whereas these two proteins suppress cell proliferation in an additive manner XREF_BIBR, XREF_BIBR."
TP53 bound to DAXX activates apoptotic process. 1 / 1
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"For example, it has been shown that DAXX interacts with p53 and promotes p53 dependent apoptosis."
TP53 bound to BCL2 activates apoptotic process. 1 / 1
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"Taken together, these findings establish an interaction between p53, c-myc, Bcl-2, p21, p27 and PI3K and Akt pathway and CF induced apoptosis in MSTO-211 and HCT-116 cells, which may improve prevention outcomes for mesothelioma and colon cancer."
TP53 bound to HIF1A activates apoptotic process. 1 / 1
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"Alternatively, HIF-1alpha can bind to the tumor suppressor p53 and promote p53 dependent apoptosis."
TP53 bound to CDKN1B activates apoptotic process. 1 / 1
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"Taken together, these findings establish an interaction between p53, c-myc, Bcl-2, p21, p27 and PI3K and Akt pathway and CF induced apoptosis in MSTO-211 and HCT-116 cells, which may improve prevention outcomes for mesothelioma and colon cancer."
TP53-R337H activates apoptotic process. 1 / 1
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"In addition, in human H1299 lung carcinoma cells, which also lack endogenous p53, ectopically expressed TP53 R337H mutant was competent to induce apoptosis."
TP53 bound to DMP1 activates apoptotic process. 1 / 1
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"In Arf-null cells, Dmp1 physically interacts with p53 to induce senescence or apoptosis for tumor suppression."
TP53 bound to BAX activates apoptotic process. 1 / 1
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"Bax induces apoptosis in cancer cells via p53 dependent and p53 independent pathways; cooperation between p53 and Bax can induce apoptosis."
TP53 bound to SKIL activates apoptotic process. 1 / 1
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"Moreover, Skil and SnoN can directly bind and activate p53 to induce apoptosis 32."
TP53-P151S activates apoptotic process. 1 / 1
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"Ser 15 phosphorylation of mutant p53 (P151S) protein involves in BAX and BAK mediated apoptosis caused by GA.."
TP53 bound to E6 activates apoptotic process. 1 / 1
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"E6 and E7 interact with the tumour suppressor proteins p53 and pRb respectively to inhibit apoptosis and abrogate cell cycle checkpoints to allow replication of the virus genomes in differentiated epithelial cells."
TP53 bound to TP73 activates apoptotic process. 1 / 1
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"Taken together, these results suggest that a functional interaction between p53 and p73 in MCF7 cells leads to enhanced induction of apoptosis."
TP53 bound to ANXA1 activates apoptotic process. 1 / 1
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"Then, ANXA1 binds to p53, increases p53 transcriptional activity and induces the expression of the pro apoptotic protein Bid and activates the caspase-3 apoptosis pathway, eventually resulting in cell apoptosis after OGD/R."
TP53 bound to E2 activates apoptotic process. 1 / 1
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"In contrast, the interaction between HPV16 E2 and p53 is not required for this E2 protein to induce apoptosis in HPV transformed cells."
TP53-V272M activates apoptotic process. 1 / 1
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"We also show that the p53 mutant V272M, which exhibits sequence specific DNA binding in vitro, is nonetheless defective for transactivation and is unable to induce apoptosis in vivo."
TP53 bound to CDKN1A activates apoptotic process. 1 / 1
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"Taken together, these findings establish an interaction between p53, c-myc, Bcl-2, p21, p27 and PI3K and Akt pathway and CF induced apoptosis in MSTO-211 and HCT-116 cells, which may improve prevention outcomes for mesothelioma and colon cancer."
TP53 bound to PI3K activates apoptotic process. 1 / 1
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"Taken together, these findings establish an interaction between p53, c-myc, Bcl-2, p21, p27 and PI3K and Akt pathway and CF induced apoptosis in MSTO-211 and HCT-116 cells, which may improve prevention outcomes for mesothelioma and colon cancer."
TP53 bound to STAT1 activates apoptotic process. 1 / 1
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"STAT1 interacts directly with p53 and induces cell growth arrest and apoptosis, as shown in XREF_FIG."
TP53 bound to S100A4 activates apoptotic process. 1 / 1
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"Recently, Grigorian et al demonstrated that S100A4 interacts with the tumor suppressor protein p53 to enhance p53 dependent apoptosis."
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"Interestingly, over-expression of p53-WT promoted CPT induced PARP-1 degradation and apoptosis, whereas over-expression of p53-S15A or p53-S20A or p53 S46A mutant failed to induce PARP-1 degradation and TUNEL apoptosis after CPT treatment (XREF_FIG and XREF_SUPPLEMENTARY)."
TP53 bound to NME1 activates apoptotic process. 1 / 1
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"The interaction between P53 and Nm23 may lead to cell cycle arrest and apoptosis."
TP53 bound to BCL2L1 activates apoptotic process. 1 / 1
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"In the mitochondria, p53 interacts with Bcl-2 and Bcl-X L, thereby triggering transcription independent apoptosis."
TP53-R175H activates apoptotic process. 1 / 1
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"ZMC1 raises intracellular Zn 2+ levels to return p53 R175H mutant (zinc deficient) to " Wt-like-p53 " conformation via the recombination of Zn 2+ and p53 R175H, which induces apoptosis in murine cell lines and significantly increases the median survival of KPC mice model."
TP53-R273H activates apoptotic process. 1 / 1
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"Indeed, downregulation of mutant p53 in T47D (p53 L194F), MDA-MB-231 (p53 R280K), and MDA-MB-468 (p53 R273H) breast cancer cell lines induces PARP dependent apoptosis."
TP53 bound to PIN1 activates apoptotic process. 1 / 1
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"By contrast, a p53 mutant (p53NLSm S46wt) that lacked the remaining two major Pin1 binding sites (Ser33 and Thr81) could efficiently induce p53 Ser46 phosphorylation; p53NLSm S46wt also promoted p53 binding to Pin1 and led to p53 transcription independent apoptosis in response to HS."
TP53 bound to MYC activates apoptotic process. 1 / 1
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"Taken together, these findings establish an interaction between p53, c-myc, Bcl-2, p21, p27 and PI3K and Akt pathway and CF induced apoptosis in MSTO-211 and HCT-116 cells, which may improve prevention outcomes for mesothelioma and colon cancer."
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"A functional variant of p53 (Pro72Arg) has been shown to induce apoptosis markedly better than the wild-type variant, and has been associated juvenile chronic arthritis [XREF_BIBR] but not with adult-onset RA [XREF_BIBR]."
TP53 bound to EGR1 activates apoptotic process. 1 / 1
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"Binding of p53 to the EGR1 promoter in response to DNA damage leads to sustained expression of EGR1 and efficient apoptosis [XREF_BIBR]."
TP53 bound to E7 activates apoptotic process. 1 / 1
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"E6 and E7 interact with the tumour suppressor proteins p53 and pRb respectively to inhibit apoptosis and abrogate cell cycle checkpoints to allow replication of the virus genomes in differentiated epithelial cells."
Mutated TP53 bound to Met-Gln activates apoptotic process. 1 / 1
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"While MQ binding to mutant p53 can restore p53 dependent apoptosis, MQ binding to other cellular proteins may not necessarily have major effects on cell growth and survival, except for binding to TrxR and GSH and possibly other anti-oxidative proteins, as discussed above."
TP53 bound to MDM2 and lanA1 activates apoptotic process. 1 / 1
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"The use of the MDM2 inhibitor Nutlin-3a disrupts the p53, MDM2, and LANA complex inducing a specific and highly potent activation of apoptosis in PEL cells [XREF_BIBR]."
TP53 bound to VIM activates apoptotic process. 1 / 1
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"Cleavage of p53 and vimentin complex enhances tumor necrosis factor related apoptosis inducing ligand mediated apoptosis of rheumatoid arthritis synovial fibroblasts."
TP53 bound to RITA1 activates apoptotic process. 1 / 1
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"RITA binds p53 N-terminal domain with high affinity and induces many cancer cells apoptosis in a p53 dependent manner in vitro and in vivo [XREF_BIBR]."
TP53 bound to p53Delta30 activates apoptotic process. 1 / 1
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"PC4 also stimulates the recruitment of p53 and p53Delta30 to p53 response elements such as Bax and p21 in vivo through its interaction with p53 and enhances the apoptosis."
TP53 bound to RASSF6 activates apoptotic process. 1 / 1
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"RASSF6 interacts with MDM2, stabilizes p53, and induces apoptosis and cell-cycle arrest.17 RASSF6 forms a complex with MST1/2, but, in contrast to RASSF1A and MST2, RASSF6 and MST1/2 form a complex and inhibit each other under basal conditions.18 However, when certain stimuli, such as okadaic acid treatment, trigger dissociation of the complex, the Hippo pathway is activated and, simultaneously, RASSF6 induces apoptosis independently of the Hippo pathway."
TP53 bound to protein activates apoptotic process. 1 / 1
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"The protein identified as TNFRSF10B, also known as DR5, interacts with p53 to induce apoptosis XREF_BIBR."