"XREF_BIBR Phosphorylated p53 up-regulates p21 Waf1 and Cip1 transcription via a p53 responsive element and activation of p53 leads to either cell cycle arrest and DNA repair or apoptosis."
"This finding suggests that an earlier G1 arrest of hydroxyurea treated HCT116 DeltaPR130 cells is due to an augmented phosphorylation of p53, which activates p21 expression (Figs."
"XREF_BIBR During cell cycle stages when CDC2 and cyclin B or CDK2 and cyclin A are active, p53 is phosphorylated and upregulates p21 Waf1 and Cip1 transcription via a p53 responsive element."
"AF metabolites, presumably though the CYP and SULT driven bioactivation pathway, have been shown to be DNA damaging agents, inducing DNA protein crosslinks, cytokeratin-RNA crosslinks, phosphorylation of p53, increased expression of p21, gamma-Histone 2AX (gamma-H2AX), reactive oxygen species mediated apoptosis, and S-phase arrest in sensitive populations of cells [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR]."
"Increased phosphorylation of p53 may up-regulate expression of p21 leading to cell cycle arrest or the expression of cell surface receptors like Fas as well as mitochondrial pro apoptotic proteins like Bax, Bak, PUMA and NOXA XREF_BIBR, XREF_BIBR."
"Transduction of mesothelioma cells with adenoviruses bearing the p53 gene (Ad-p53) induced phosphorylation of p53, upregulated Mdm2 and p21 expression levels and decreased phosphorylation of pRb."
"Upregulation and phosphorylation of TP53 are in turn sufficient to activate CDKN1A gene expression."
"p53 is phosphorylated and upregulates p21 Waf1 and Cip1 transcription via a p53 responsive element during cell-cycle stages."