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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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TP53 increases the amount of CDKN1A. 9 / 743
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"p53 binds to the p21 promoter of hESCs, but does not promote p21 transcription in hESCs, as it does in differentiated human mesenchymal stem cells (hMSCs)."
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"In HCT116 wt cells, a strong p53 dependent upregulation of p21 level was also detected (XREF_FIG, A and B)."
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"The over-expression p53 presumably enhances expressions of Bax, Bcl-2 and p21 leading to cell cycle arrest and apoptosis."
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"It seems likely that the up-regulation of p53 in U87 cells induced by EcTI activated the cell cycle inhibitor p21 expression with simultaneous cyclin D1."
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"p53 independent elevation of p21 expression by PMA results from PKC mediated mRNA stabilization."
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"Cdkn1a and Cd44 are known downstream targets of the p53 tumor suppressor; with CD44 expression being suppressed by p53 in contrast to Cdkn1a expression which is enhanced by p53."
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"p53 knockdown in cancer cells reduces the level of p21, which, in turn, increases the activity of CDK2 followed by induction of Rb1 hyperphosphorylation and its dissociation with transcriptional factor E2F3."
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"It has been confirmed that p21 expression is mediated by p53 dependent and p53 independent pathways."
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"Specifically, in cell-cycle arrest at the G 1 phase, p53 enhances p21 transcription, which in turn inhibits cyclin dependent kinase activity."
Modified TP53 increases the amount of CDKN1A. 10 / 57
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"Overexpression of p53 increased p21 protein level in all cell lines (XREF_FIG)."
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"In the quiescence period, the increase in p53 expression activates p21 expression, which inhibits Rb phosphorylation and arrests the cell cycle in G1."
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"Compounds 10a and (-)-10a increase p53 protein levels, activate p53 dependent MDM2 and p21 transcription in MDM2 amplified cells, and show improved selectivity for growth inhibition in wild type p53 cell lines over the parent compound."
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"We used the p53 plasmid to find that the overexpression of p53 increases the p21 protein level in ACC."
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"Loss of p53 increased the growth rate of cells and suppressed p21 expression."
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"In the present study, p21 expression may have been induced by p53 expression after DNA damage."
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"In A549, tetrazolium violet blocked the progression of the cell cycle at G1 phase by inducing p53 expression and further up-regulating p21 and WAF1 expression."
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"Elevations in p53 expression and p53 Ser15 phosphorylation enhance p53 transcriptional activity, resulting in increased MKP-1 and p21 levels, and increased gene expression of Wip1, p21, and Cdkn2d (Cdk4 inhibitor)."
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"As expected ectopic expression of p53 increased p21 level in these cells, and interestingly we could not observe any significant effect of p53 expression on p21 activation in APE1 downregulated cells (XREF_FIG)."
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"Indeed, low levels of p53 have been demonstrated to induce p21 expression and cause cell cycle arrest XREF_BIBR XREF_BIBR."
Transcriptionally active TP53 increases the amount of CDKN1A. 10 / 44
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biopax:ctd
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biopax:ctd
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signor
"p53 then transcriptionally upregulates the expression of target genes, of which p21 is critical for inhibiting G1/S entry."
biopax:ctd
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Mutated TP53 increases the amount of CDKN1A. 10 / 12
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"One explanation of this phenomenon is the possibility that p53 mutation led to low p21 expression and changed susceptibility to cancer treatment [XREF_BIBR, XREF_BIBR]."
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"However, our qPCR analysis showed that expression of CDKN1A, PMAIP1, BBC3, and 14-3-3sigma was increased by APR-246 in the two mutant p53 expressing cell lines."
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"Most of these poorly BCL-xL-sequestered p53 mutants, however, did not activate p21 or puma transcription, despite exhibiting near wild-type-like DNA binding in vitro (XREF_FIG)."
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"Furthermore, constitutively activated mutant p53 378D promoted higher p21 expression than the unphosphorylatable p53 378A mutant (XREF_FIG)."
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"Surprisingly, mutant p53 transcriptionally activates the expression of p21, which localizes to the cytoplasm of HGSC cells where it plays a non canonical, pro proliferative role."
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"In contrast, transfection of the p53 mutant 248Trp failed to activate WAF1 and Cip1 expression."
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"In our models, p21 expression was induced by these agents in both p53 wild-type (THJ-11T, THJ-29T) and p53 mutant (THJ-16T, THJ-21T) cells."
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"The residual repressive activity was the result of the ability of p53 to induce apoptosis as a p53 mutant that is able to induce p21 expression but unable to induce apoptosis (p53 R175P) completely lost repressive activity in the absence of p21 (XREF_FIG)."
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"Thus, cells expressing mutant p53 that can not induce transcription of p21 and Bax fail to undergo cell cycle arrest or apoptosis in response to DNA damage, leading to unregulated cell division, additional mutagenesis, and, potentially, tumor formation 20."
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"Since mutant p53 depletion in Panc-1 cells further augmented SAHA induced decrease in cell viability and also increase in the amount of cell cycle related p21 WAF1, it is possible that, unlike MiaPaCa-2 cells, mutant p53 knockdown in Panc-1 cells might contribute largely to the potentiation of SAHA mediated cell cycle arrest and cell cycle retardation rather than cell death."
Phosphorylated TP53 increases the amount of CDKN1A. 8 / 8
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"XREF_BIBR Phosphorylated p53 up-regulates p21 Waf1 and Cip1 transcription via a p53 responsive element and activation of p53 leads to either cell cycle arrest and DNA repair or apoptosis."
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"This finding suggests that an earlier G1 arrest of hydroxyurea treated HCT116 DeltaPR130 cells is due to an augmented phosphorylation of p53, which activates p21 expression (Figs."
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"XREF_BIBR During cell cycle stages when CDC2 and cyclin B or CDK2 and cyclin A are active, p53 is phosphorylated and upregulates p21 Waf1 and Cip1 transcription via a p53 responsive element."
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"AF metabolites, presumably though the CYP and SULT driven bioactivation pathway, have been shown to be DNA damaging agents, inducing DNA protein crosslinks, cytokeratin-RNA crosslinks, phosphorylation of p53, increased expression of p21, gamma-Histone 2AX (gamma-H2AX), reactive oxygen species mediated apoptosis, and S-phase arrest in sensitive populations of cells [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR]."
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"Increased phosphorylation of p53 may up-regulate expression of p21 leading to cell cycle arrest or the expression of cell surface receptors like Fas as well as mitochondrial pro apoptotic proteins like Bax, Bak, PUMA and NOXA XREF_BIBR, XREF_BIBR."
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"Transduction of mesothelioma cells with adenoviruses bearing the p53 gene (Ad-p53) induced phosphorylation of p53, upregulated Mdm2 and p21 expression levels and decreased phosphorylation of pRb."
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"Upregulation and phosphorylation of TP53 are in turn sufficient to activate CDKN1A gene expression."
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"p53 is phosphorylated and upregulates p21 Waf1 and Cip1 transcription via a p53 responsive element during cell-cycle stages."
Transcriptionally active TP53 acetylated on K381, K386, K382, K370, K372, K373, K120, and K164 increases the amount of CDKN1A. 7 / 7
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biopax:pid
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Transcriptionally active TP53 methylated on R335, R337, and R333 increases the amount of CDKN1A. 7 / 7
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biopax:pid
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Transcriptionally active TP53 ubiquitinated on K320 increases the amount of CDKN1A. 7 / 7
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biopax:pid
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Acetylated TP53 increases the amount of CDKN1A. 5 / 5
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"The acetylated p53 enhanced p21 and BAX expression and induced apoptosis."
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"Acetylated p53 increases the expression of p21 and further promotes apoptosis in A549 cells."
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"The up-regulated acetylation of p53 promoted the transcriptional activity of p53 and induced the expression of p21, which consequently caused cell cycle arrest at G1 phase."
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"The acetylation of p53 induces subsequent expression of p21, leading to the induction of cellular senescence."
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"At least in part, HDACi induce cell-cycle arrest by causing accumulation of hyperacetylated p53, which then induces expression of p21, leading to inhibition of cyclins D and A, which are required for cell-cycle progression."
TP53 phosphorylated on S15 increases the amount of CDKN1A. 2 / 2
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"Phosphorylation of p53 on S15 by ATM and ATR and/or on S20 by CHK1 and CHK2 stabilizes p53 protein XREF_BIBR - XREF_BIBR and up-regulates the expression of p21 (also known as CIP1 and WAF1), an inhibitor of cyclin E/cyclin dependent kinase 2 (CDK2) that controls G1/S progression."
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"Elevations in p53 expression and p53 Ser15 phosphorylation enhance p53 transcriptional activity, resulting in increased MKP-1 and p21 levels, and increased gene expression of Wip1, p21, and Cdkn2d (Cdk4 inhibitor)."
TP53 bound to TOP3A increases the amount of CDKN1A. 1 / 1
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"The binding of TOP3A to both p53 and p21 promoter regions promoted the expression of p53 and p21, and mediated tumor suppression in a p53 dependent manner [XREF_BIBR]."
TP53 bound to TFAP2alpha increases the amount of CDKN1A. 1 / 1
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"In addition, TFAP2alpha binds directly to TP53 and stimulates p21 expression [XREF_BIBR]."
TP53 bound to ARID1A increases the amount of CDKN1A. 1 / 1
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"XREF_BIBR, XREF_BIBR, XREF_BIBR ARID1A can also directly bind p53, enhance its transactivation activity and promote the expression of the cell cycle inhibitor CDKN1A."
TP53 bound to SP1 increases the amount of CDKN1A. 1 / 1
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"Taken together, the result demonstrated that p21 transcription during replicative senescence of HEFs is up-regulated by increase in DNA binding activity and interaction between p53 and Sp1 via phosphorylation."
TP53 bound to its increases the amount of CDKN1A. 1 / 1
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"A possible mechanism behind the changes in SWI-SNF composition could be that phosphorylation of TMF-1 by Fer and/or PDGFRbeta promotes disruption of the TMF-1-containing repressive SWI and SNF complex; this may lead to release of Brg-1 followed by its binding to p53, which activates the transcription of CDKN1A, although interaction with the kinase inactive receptor may maintain a repressive SWI and SNF complex and inhibit p21 expression."
TP53 bound to ABL1 increases the amount of CDKN1A. 1 / 1
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"The demonstration that c-Abl binds to p53, induces the transactivation function of p53 and activates p21 expression has supported involvement of c-Abl in regulation of the p53 dependent G1 arrest response."
TP53-R248W increases the amount of CDKN1A. 1 / 1
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"They demonstrated that p53 R248W knockdown by p53 R248W -specific siRNA induced apoptosis in MDAH087 cells carrying only p53 R248W and increased p21 protein levels and MDM2 promoter activity in p53-null H1299 cells transfected with both wtp53 and mutp53 [XREF_BIBR]."
TP53 acetylated on K373 and K382 increases the amount of CDKN1A. 1 / 1
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"Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21 (Waf1 and Cip1)."
TP53 acetylated on K382 increases the amount of CDKN1A. 1 / 1
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"Western blot data showed that quisinostat up-acetylated p53 at K382 and K373 sites in H460 cells as well as A549 cells and significantly increased the expression of p21 (Waf1 and Cip1) in a dose dependent manner."
TP53 phosphorylated on S46 increases the amount of CDKN1A. 1 / 1
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"In malignant melanoma cells, the apoptotic response was accompanied with ROS production, activation of the p38 MAPK, phosphorylation of Ser46 of p53 which is indicative of apoptotic cells, and increased expression of p21 and p27."
TP53 bound to CDKN1A increases the amount of CDKN1A. 1 / 1
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"p53 binds a promoter of the p21 gene and activates the transcription of p21."
TP53 bound to they increases the amount of CDKN1A. 1 / 1
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"For example, WRN proteins may be involved in the regulation of apoptosis because they can interact with p53 and activate p53 dependent transcription of p21 and Waf1 [XREF_BIBR, XREF_BIBR]."