IndraLab

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TP53 increases the amount of TP53. 10 / 561
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"Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients."
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"Increasing the nuclear p53 levels depletes the pool of cytoplasmic p53, which is more effective in promoting apoptosis by acting on the mitochondria (62)."
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"Lack of p53 protein in MCF7 p53 cells was confirmed by immunoblot analysis after doxorubicin treatment to induce maximum p53 levels upon DNA damage activation (Fig. 1c)."
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"Ectopic expression of a temperature sensitive (ts) p53 allele induced expression of p53 target genes and elicited both G1 and G2/M cell cycle arrest upon shift to the permissive temperature."
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"These results suggest that a ' slipped mispairing ' mechanism occurring during DNA replication may generate p53 intragenic deletion in human esophageal cancer, leading to abolished p53 mRNA expression."
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"Blocking of potential Wrap53 and p53 RNA hybrids reduces p53 levels nearly as efficiently as Wrap53 knockdown, strongly suggesting that Wrap53 regulates p53 via Wrap53 and p53 RNA interaction."
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"The loaded DOX was control released under higher GSH situation in HeLa tumor cells, and the nanosystem showed enhanced p53 gene delivery inducing an increase in p53 protein expression in these cells."
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"Inactivation of tumor-suppressor gene p53 decreases expression of p53 target genes causing malignancy, and histone deacetylase (HDAC) inhibitors reactivate the expressions of the genes suppressing tumor growth."
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"Wolf D. & Rotter V. (1985) Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells."
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"All alleles carried a transcriptional stop element flanked by LoxP sites (Lox-Stop-Lox or LSL) in the first p53 intron to allow regulatable p53 expression (XREF_FIG)."
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Modified TP53 increases the amount of TP53. 10 / 37
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"AGGF1 antagonizes MDM2 function to inhibit p53 ubiquitination, increases the acetylation, phosphorylation, stability and expression levels of p53, activates transcription of p53 target genes, and regulates cell proliferation, cell cycle, and apoptosis."
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"The current study demonstrated that the expression levels of EZH2 and P53 in tumor tissue and the proportion of cases with double positive expression significantly increased with increasing clinical stages of cancer, also confirming up-regulated expression of EZH2 and P53 with increasing stages."
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"Camptothecin and doxorubicin treatments in RT-4 cells or transient overexpression of p53 into p53-mutant HT1376 cells induced p53 and BTG2 expression."
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"An increased level of TP53 targeting miRNAs in GC B cells such as miR-21, miR-25 and miR-200c could promote an additional control level of TP53 expression after the activation of the DNA damage response."
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"Overexpression of p53 activates transcription of p53 effector genes, causes growth inhibition and induced apoptosis."
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"Basal levels of wild-type p53 can stimulate PGC-1alpha expression and mitochondrial biogenesis in mice, while severe cellular stress associated with telomere dysfunction and increased p53 levels can repress both PGC-1alpha and PGC-1beta expression [XREF_BIBR, XREF_BIBR]."
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"Next, to investigate whether RITA induced senescence depends on p53 status, we treated the stable-p53-knockdown cell lines HN30-shp53 and HN31-shp53 with RITA and found that knockdown of p53 protein expression markedly reduced both the expression and phosphorylation of p53 (XREF_FIG)."
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"The elevated levels of p53 further up-regulate expression of p21 and that of the pro apoptotic p53 target genes BAX and PUMA in breast cancer cells."
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"The ERalpha involvement in the ACH induced increase in p53 level is also supported by the inability of ACH to affect p53 gene expression in ERalpha negative MDA-MB-231 breast cancer cells."
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"36 Here, we observed enhanced p53 levels in Poly (I : C)-treated mice that paralleled increases in Mysm1 expression, and that there was enhanced p53 transcription in Mysm1 -/- HSCs."
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Mutated TP53 increases the amount of TP53. 10 / 25
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"Muller et al XREF_BIBR showed that p53 mutation upregulates expression of endogenous p53, binds to caspase-9 and ultimately inhibits apoptosis and mediates cisplatin resistance."
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"Treatment with poly (I : C) had no impact on WT or p53 mutant mediated expression of the p53 target genes p21 and PUMA (BBC3) (XREF_SUPPLEMENTARY)."
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"Indeed, tumours harbouring p53 mutations, which lead to expression of inactive p53 protein, account for about 50% of all human cancers."
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"The mutation of the P53 gene in tumors will cause the imbalance of the protein level of P53, which will lead to further tumor expansion."
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"Mutant p53 does not induce the expression of wild-type (wt) p53 downstream genes because of the loss of the ability to bind to p53 response elements [XREF_BIBR, XREF_BIBR]."
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"Dominant negative effects of mutant p53 have been shown to suppress wild-type p53 expression and function."
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"While it is known that a mutant p53 protein can interact with its wild-type counterpart to inac- tivate the function of the wild-type protein (domi- nant negative mutation), there is also evidence tha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"P53 mutations increase expression of p53 and bind with the p35 fragment of caspase-9, which inhibits caspase-9 activity and eventually leads to CDDP resistance in cancer."
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"Transient expression of mutant p53 protein in TSGH8301 cells may induce an irreversibly stabilization of p53 and increase the steady state of p53 expression."
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"Second, we determined p53 overexpression as a surrogate marker for p53 mutation; however, not all p53 mutations lead to p53 overexpression."
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TP53 increases the amount of mutated TP53. 8 / 8
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"For example, P53 missense mutations increases the expression of mutant p53 proteins, which, in turn, decreases the infiltration of cytotoxic CD8 T cells in pancreatic cancer [80]."
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"Thus, discovery of BMI1 inhibitor and PTEN activating molecules will be beneficial for the effective anti-cancer therapy.Silencing mutant p53 expression by p53 specific siRNA in several human cancer c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus we determined the need to isolate single cell DLD1 clones with p53-EGFP reporter expression that have fairly low basal EGFP expression and that could be induced to high EGFP expression upon exposure to small molecules that restore p53 pathway signaling in mutant p53 expressing DLD1 cells."
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"It is important to note that no prior study has linked p53 or p73 to the mechanism of action of either prodigiosin or its related structures and no prior study has demonstrated the ability of these compounds to restore p53 pathway signaling in mutant p53 expressing or p53-null cancer cells."
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"MKP-1 has been shown to be transcriptionally regulated by p53, and mutations of p53 abrogate p53 dependent transcription of MKP-1 in vitro (Yang and Wu, 2004; Liu et al, 2008)."
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"These results suggest that NSC59984 restores p53 pathway signaling in mutant p53 expressing SW480 and DLD-1 human colorectal cancer cells."
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"NSC59984 specifically restores p53 pathway signaling in mutant p53 expressing human colorectal cancer cells."
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"XREF_BIBR In addition to CDKN1A and p21 CIP1, other traditional p53 targets, such as GADD45 and 14-3-3sigma, also were up-regulated but perhaps not as a result of p53 activation given that 779e cells express no detectable p53 protein and that E47 repressed the expression of mutant p53 mRNA and protein in the other 4 lines (XREF_FIG A-F)."
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Mutated TP53 increases the amount of mutated TP53. 5 / 5
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"Together, these observations support a role for germline p53 pathway SNPs not only in modulating risk of disease and tumor biology in wtTP53 cancers but also in TP53 mutant cancers, wherein alleles that increase mutant p53 levels would also increase its procancer activities."
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"Several studies documented the importance of either wild-type or mutant p53 alleles in leading to increased expression of p53 protein increased expression of both wild-type and mutant p53 protein."
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"As compared with EV transfected cells, let-7i promoter activity was significantly reduced by exogenous mutant p53 (XREF_FIG), suggesting that mutant p53 represses let-7i transcription."
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"TP53 mutations are highly frequent in cancer and lead to the expression of mutant p53 proteins that are endowed with oncogenic activities and sensitive to stress signaling."
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"Despite the partial or complete loss of sequence specific DNA binding, mutant p53 proteins can induce or repress transcription of mutant p53 specific target genes and various mutant p53 proteins can bind to oligonucleotides mimicking non B DNA structures [XREF_BIBR]."
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Phosphorylated TP53 increases the amount of TP53. 4 / 4
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"In response to stress and DNA damage, p53 is phosphorylated on multiple serine residues, including Ser 15, resulting in inhibition of degradation and increased p53 levels."
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"Cellular stresses such as irradiation, lead to phosphorylation and dissociation of p53 and MDM2, which allow p53 protein levels to increase."
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"The Chk signal transducers induce cell cycle arrest by phosphorylation of two critical effectors : inhibitory phosphorylation of the Cdc25 phosphatase results in CDK inactivation, while the activating phosphorylation of the p53 tumor suppressor stabilizes p53 and increases transcription of p53 target genes, including the cyclin dependent kinase inhibitor p21/CIP1/WAF-1."
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"1 For example, phosphorylation and acetylation of p53 have been shown to promote the expression of p53 transcriptional targets, whereas other modifications, such as ubiquitination, sumoylation, and neddylation have been associated with the suppression of p53 mediated transcription and p53 nuclear export."
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TP53 bound to HTT increases the amount of TP53. 3 / 3
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"Mutant huntingtin (mHtt) with expanded polyglutamine (polyQ) binds to p53 and upregulates levels of nuclear p53 as well as p53 transcriptional activity in neuronal cultures."
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"Mutant huntingtin interacts with p53, a transcription factor induced in response to DNA damage, and increases the levels and activity of p53 in mouse striatal cells, and in striatum and cerebral cortex from HD patients and R6/2 transgenic mice [XREF_BIBR, XREF_BIBR]."
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"Mutant huntingtin binds to p53 and upregulates the levels of nuclear p53 as well as p53 transcriptional activity in neuronal cultures."
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Acetylated TP53 increases the amount of TP53. 3 / 3
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"The increased acetylation of p53 may induce the expression of p53 dependent pro-apoptotic genes, such as NOXA or BAX [22]."
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"Subsequent assays indicated gamma-bisabolene eliciting p53 acetylation that enhanced the expression of p53 regulated apoptotic genes."
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"Based on results showing that either ubiquitinated or acetylated p53 is competent to activate transcription of p53 target genes, an activity which requires p53 tetramer formation, we chose to pursue an investigation of the latter hypothesis XREF_BIBR, XREF_BIBR."
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Methylated TP53 increases the amount of TP53. 2 / 2
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"This evidence may suggest that DNA hypomethylation of the p53 gene contributes to the enhanced p53 expression and causes abnormal apoptosis in lupus patients, a notion that needs further investigation.Several studies have demonstrated that methyl-CpG-binding domain 4 (MBD4) can be recruited by methylated DNA and thereby leading to the recruitment of histone modifying and chromatin-remodeling complexes to methylated sites [38,39]."
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"These near-polyploid cells overexpressed DNA repair genes to reduce the DNA-damage response, as well as methylating p53 promoter regions to silence p53 expression."
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TP53-R175H increases the amount of TP53. 2 / 2
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"DAXX also reduced protein, but not mRNA, levels of p53(R175H) in H1299 cells that inducibly express this mutant and increased the expression of p53 target genes including p21 and Puma (Extended Data Figs."
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"Although there was no significant difference in expression of CDKN1A, VDR, and TP53INP1 between CD24 + PC3 cells and CD24 - PC3 cells, the transfections of WT TP53, mutants TP53 R273H, TP53 V143A, and TP53 R280T, but not mutant TP53 R175H, induced the expression of these p53 target genes in CD24 - PC3 cells but not in CD24 + PC3 cells (XREF_FIG)."
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Sumoylated TP53 increases the amount of TP53. 2 / 2
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"Since p53 SUMOylation can increase p53 expression by decreasing its degradation, it is also possible that p53 SUMOylation can increase EC inflammation via regulating KLF2 expression."
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"On the other hand, sumoylation of DJ-1 and p53 reactivates p53 transcription through a Topors and p53BPs complex [XREF_BIBR]."
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Ubiquitinated TP53 increases the amount of TP53. 2 / 2
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"Together, these results indicate that Hoxa2 negatively affects RCHY1 stability and RCHY1 dependent ubiquitination of p53 thereby inducing a stabilization of p53 and an increase in p53 protein level."
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"In unstressed cells, p53 is constitutively polyubiquitinated, which leads to its proteasomal degradation, keeping p53 levels low (Gomez-Lazaro et al., 2004) ."
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TP53 bound to EP300 increases the amount of TP53. 2 / 2
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"In contrast, MCF-7 cell treatment with TNF-alpha led to dissociation of the HDAC3-ERalpha complex and substitution of the occupancy on the promoter by the p53-p300 complex, thus accelerating p53 target gene expression."
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"In contrast, MCF-7 cell treatment with TNF-alpha led to dissociation of the HDAC3 and ERalpha complex and substitution of the occupancy on the promoter by the p53 and p300 complex, thus accelerating p53 target gene expression."
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TP53 bound to TOP3A increases the amount of TP53. 1 / 1
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"The binding of TOP3A to both p53 and p21 promoter regions promoted the expression of p53 and p21, and mediated tumor suppression in a p53 dependent manner [XREF_BIBR]."
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TP53 phosphorylated on S392 increases the amount of TP53. 1 / 1
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"According to the western blotting, phosphorylation of p53 at Ser15, Ser376, and Ser392 and acetylation of p53 at Lys370 and Lys382 were inhibited, resulting in the deficiency of p53 expression."
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Phosphorylated TP53 increases the amount of mutated TP53. 1 / 1
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"Chronic exposure to BaP induced malignant transformation of cells, in which there were increased levels of mutant p53 (mt-p53) and reduced expression of wild-type p53 (wt-p53) and phosphorylated p53 (p-p53)."
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TP53 bound to KMT2D increases the amount of TP53. 1 / 1
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"On one hand, KMT2D interacts directly with p53 to promote expression of p53 target genes."
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TP53 bound to DACH1 increases the amount of TP53. 1 / 1
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"As DACH1 bound p53 and induced p53 target expression, we considered the possibility that DACH1 may enhance p53 dependent transcriptional activity."
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TP53 acetylated on K120 increases the amount of TP53. 1 / 1
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"Among them, TIP60 (KAT5) is reported to acetylate p53 at K120, which promotes the expression of the pro apoptotic p53 target gene PUMA and thus induces apoptosis upon DNA damage in human colon cancer [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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Lysine-acetylated TP53 increases the amount of TP53. 1 / 1
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"The acetylation at multiple lysine residues of P53 by P300/CBP promotes p53 gene transcription and the expression of proapoptotic genes [78]."
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TP53 increases the amount of sumoylated TP53. 1 / 1
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"On the other hand, sumoylation of DJ-1 and p53 reactivates p53 transcription through a Topors and p53BPs complex [XREF_BIBR]."
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TP53-V143A increases the amount of TP53. 1 / 1
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"Although there was no significant difference in expression of CDKN1A, VDR, and TP53INP1 between CD24 + PC3 cells and CD24 - PC3 cells, the transfections of WT TP53, mutants TP53 R273H, TP53 V143A, and TP53 R280T, but not mutant TP53 R175H, induced the expression of these p53 target genes in CD24 - PC3 cells but not in CD24 + PC3 cells (XREF_FIG)."
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TP53 bound to PTEN increases the amount of TP53. 1 / 1
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"Also, PTEN Akt-independently interacts with p53 and cyclin D, and stabilizes p53, whose half-life is short in the nucleus, and promotes transcription of p53 XREF_BIBR XREF_BIBR."
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TP53 acetylated on K370 increases the amount of TP53. 1 / 1
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"According to the western blotting, phosphorylation of p53 at Ser15, Ser376, and Ser392 and acetylation of p53 at Lys370 and Lys382 were inhibited, resulting in the deficiency of p53 expression."
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TP53 increases the amount of TP53-Y220C. 1 / 1
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"To further address this issue, we also performed the p53 transcriptional reporter assay in Hep3B cells and found that the Y220C mutant of p53 did not activate p53 dependent transcription (XREF_FIG)."
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Modified mutated TP53 increases the amount of TP53. 1 / 1
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"We report here that down-regulation of mutant p53 expression in several human cancer cell lines harbouring mutant p53 by siRNA mediated silencing induced the expression of p53 dependent apoptotic and repair genes."
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TP53 bound to SOCS3 increases the amount of TP53. 1 / 1
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"Immunoprecipitation analyses revealed that SOCS3 bound to p53 and subsequently increased the expression of p53 and its target genes, contributing to IL-22-mediated HSCs senescence [XREF_BIBR]."
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TP53 phosphorylated on amino acid 15 increases the amount of TP53. 1 / 1
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"We measured nuclear phospho-p53 Ser15 levels after HI by Western blot analysis because phosphorylation of p53 at serine 15 activates p53 mediated proapoptotic transcription."
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TP53 phosphorylated on S6 increases the amount of TP53. 1 / 1
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"For example, JNK can phosphorylate p53 at Ser6, which inhibits ubiquitin mediated p53 degradation and increases the p53 expression level, resulting in p53 mediated up-regulation of several pro apoptotic genes, including Bax and PUMA [XREF_BIBR, XREF_BIBR]."
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TP53-R280T increases the amount of TP53. 1 / 1
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"Although there was no significant difference in expression of CDKN1A, VDR, and TP53INP1 between CD24 + PC3 cells and CD24 - PC3 cells, the transfections of WT TP53, mutants TP53 R273H, TP53 V143A, and TP53 R280T, but not mutant TP53 R175H, induced the expression of these p53 target genes in CD24 - PC3 cells but not in CD24 + PC3 cells (XREF_FIG)."
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TP53 phosphorylated on S15 increases the amount of TP53. 1 / 1
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"ultimate carcinogen benzo[a]pyrene diol epoxide (BPDE) Analyses of proteins in treated cells indicated that p53 was phosphorylated at Ser15 but not at Ser20 within 30 min of treatment, and this correlated with an increase in the total amount of p53 protein."
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TP53-R273H increases the amount of TP53. 1 / 1
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"Although there was no significant difference in expression of CDKN1A, VDR, and TP53INP1 between CD24 + PC3 cells and CD24 - PC3 cells, the transfections of WT TP53, mutants TP53 R273H, TP53 V143A, and TP53 R280T, but not mutant TP53 R175H, induced the expression of these p53 target genes in CD24 - PC3 cells but not in CD24 + PC3 cells (XREF_FIG)."
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TP53 increases the amount of TP53-R270H. 1 / 1
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"We generated female p53 (lox and lox)/FAK (+/+)/WapCre, p53 (lox and lox)/FAK (flox/+)/WapCre and p53 (lox and lox)/FAK (flox/-)/WapCre mice, and mice with WapCre mediated conditional expression of p53 (R270H), the mouse equivalent of human p53 (R273H) hot spot mutation, together with conditional deletion of FAK, P53 (R270H/+)/FAK (lox/+)/WapCre and p53 (R270H/+)/FAK (flox/-)/WapCre mice."
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TP53 bound to DAXX increases the amount of TP53. 1 / 1
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"However, another group suggested that interaction between DAXX and wild-type p53 modulates expression of p53 target genes differentially, for example promoting the activation of Puma and inhibition of p21 and Mdm2."
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