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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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TP53 activates TP53. 8 / 900
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"Expression of p53 restores an appropriate activation of the p53 downstream signaling in p53 mutated tumor cells probably because p53 mutated cells often have intact p53-downstream pathways."
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"Therefore, those findings confirm that Tip60 mediates the acetylation of p53 at K120, which stimulate the p53 activity in inducing a proapoptotic target gene PUMA."
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"Several small molecules have been tested for p53 reactivation in mutp53 carrying cells [XREF_BIBR, XREF_BIBR, XREF_BIBR] while studies exploiting the effect of natural compounds are limited."
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"p53 acetylation and H1.2 phosphorylation promote p53 dependent apoptotic cell death."
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"Changes in expression of gene p53, and also its mutations, cause variations of cellular protein p53 concentration."
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"It has been reported that acetylation of p53 by p300 and CBP on multiple lysine residues leads to the activation of p53 transcriptional activity [XREF_BIBR]."
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"Conversely, the inhibition of the HSF1 response imparted by these drugs was largely rescued by overexpression of mutp53 (XREF_FIG), underlining the importance of mutp53 in stimulating MAPK and PI3K signaling to regulate HSF1 activity."
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"For example, MDM2 can directly bind to p53 to inhibit its transcriptional activity; quickly enhance the ubiquitination and degradation of p53 through ubiquitin-E3 ligase; and promote p53 degradation by blocking p53 's transport from the nucleus to the cytoplasm XREF_BIBR XREF_BIBR."
TP53 bound to MDM2 activates TP53. 10 / 14
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"MDM2 binds p53 at its transactivation domain to block its ability to activate transcription, promotes the nuclear export of p53, and may enhance p53 degradation by serving as a ubiquitin ligase."
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"p53 alpha-Helix mimetics antagonize p53 and MDM2 interaction and activate p53."
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"This interaction between MDM2 and p53 also allows MDM2 to shuttle p53 out of the nucleus in a RING-domain dependent manner."
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"Mdm2 binds to P53 and leads to complete elimination of P53 through proteolytic degradation."
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"One of the major endogenous negative regulators of p53 in humans is hDM2, a ubiquitin E3 ligase that binds to p53 causing proteasomal p53 degradation."
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"Inhibition of p53 and Mdm2 interactions by small molecule (nutlin-3) or silencing Mdm2 did not rescue the p53 degradation, indicating that HCV infection induces degradation of p53 independent of the Mdm2 pathway."
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"Nutlins were originally identified as potent small molecules that inhibit the interaction between p53 and MDM2, which promote p53 degradation XREF_BIBR, XREF_BIBR, XREF_BIBR."
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"Furthermore, high levels of phosphorylation of p53 at Serine 15 (Ser15), modulate cell cycle checkpoint kinase Ataxia-Telangiectasia Mutated (ATM) and Ataxia-Telangiectasia and Rad3 related (ATR) that impede MDM2 binding to p53 and subsequently promote p53 accumulation and activation in response to DNA damage [XREF_BIBR, XREF_BIBR]."
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"MDM2 binds to a tumour suppressor protein p53 and induces ubiquitin dependent degradation of p53, which inhibits p53 functions XREF_BIBR."
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"Later, Zawacka-Pankau et al. showed that in cultured cells, PpIX binds to p53 at its N-terminus and disrupts the interaction between p53 and HDM2 (the human homologue of MDM2), thereby disrupting HDM2 's negative regulation of p53."
TP53 activates mutated TP53. 10 / 12
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"Sirt1 may inactivate the 382nd lysine residue of p53, reduce the expression of the wild-type p53 protein combining with the DNA cis element to promote p53 mutation."
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"We found that JNK mediated phosphorylation of Thr 81 in the proline rich domain (PRD) of p53 enabled wild-type p53, as well as mutant p53, to form a complex with p73."
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"On the other hand, overexpressed RPS27 may in turn stabilize mutant p53, since ectopic expression of RPS27 could increase p53 levels (XREF_FIG)."
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"Thus, these data indicate that GCS suppression restores wild-type p53 expression and leads mutant p53 tumors to induced-apoptosis."
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"XREF_BIBR The targeting of mutant TP53 epitopes or TP53 overexpression in tumors by vaccine has shown promise in a number of in vivo settings."
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"Genotoxic stressors cause strong promoter activation and upregulation of p53 transcription, which could increase p53 mutation frequencies."
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"19 In this paper, we report that Delta122p53 enhanced the tumor-suppressor activities of the attenuated p53 mutant mDeltapro."
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"The constitutive overexpression of p53 overcame endogenous negative regulation in D283 cells, and rescued TP53 mutation in VP-16-treated Daoy cells."
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"Of note, in all of these cases, heterogeneity of p53 expression could be observed, raising the possibility of focal TP53 mutations in a tumor subclone that may not have been detected by the sequencing assays (XREF_FIG)."
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"Delta122p53, a mouse model of Delta133p53alpha, enhances the tumor-suppressor activities of an attenuated p53 mutant."
Mutated TP53 activates TP53. 10 / 11
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"These data indicate that ectopic expression of wild-type p53 can repress dUTPase promoter activity and that ectopic p53 mutant expression can induce dUTPase promoter activity in the HCT116 p53 isogenic cell-line models."
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"We show here that overexpression of the GOF mutant p53 G245D and other GOF p53 mutants enhances the invasive cell growth of p53 deficient head and neck squamous cell carcinoma (HNSCC) UM-SCC-1 cells both in in vitro three-dimensional culture and in an in vivo orthotopic nude mouse model of HNSCC through a novel transcription independent mechanism."
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"These ' gain-of-function ' (GOF) TP53 mutations cause mutp53 to accumulate at high levels in cells, contributing to tumorigenesis and the development of drug resistance XREF_BIBR."
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"The overexpression of mutant p53 stimulates serum p53 antibody production in patients with colorectal carcinoma even in superficial tumors."
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"EZH2 augmented p53 GOF mutant mediated cancer growth and metastasis by increasing protein levels of mutant p53."
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"Over-expression of the dominant negative p53 mutant DeltaTAp53, which inhibits p53 activity, prevented the TPA induced K14 down-regulation in C9 cells."
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"p53 tumor suppressor protein is involved in the regulation of centrosome duplication : loss of p53 as well as expression of certain p53 mutants result in deregulated centrosome duplication and centrosome amplification."
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"The first such mechanism discovered showed that mutant p53 proteins abrogate the tumor-suppressive activities of the p53 family members p63 and p73."
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"Unlike wt p53, mutant p53 is normally expressed at high levels in tumor cells, most likely due to the inability to induce components of p53 negative-feedback loops such as MDM2, Cop1, or Pirh2."
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"More significantly, Ser20 phosphorylation of specific p53 mutants with oxali-Pt also activates p53 function, and this raises the likelihood that other p53 mutants in refractory human ovarian cancers could also be functionally activated with distinct drugs, such as oxali-Pt, to restore therapeutic sensitivity."
Modified TP53 activates TP53. 5 / 5
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"In most cell types, p53 expression leads to increased PUMA gene expression and subsequent PUMA mediated apoptosis requires functional p53."
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"Analysis of GFAP expression in transgenic mice with 0,1, or 2 copies of p53 showed that loss of p53 expression also blocked precocious GFAP expression in both N1ICD; hGFAP-cre; p53-/- and N1ICD; hGFAP-cre; p53 +/- mice (XREF_SUPPLEMENTARY)."
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"Nutlin 3a treatment of wild type p53 expressing cultured cancer cells increases p53 levels and causes p53 mediated transactivation, cell cycle arrest, and apoptosis [XREF_BIBR]."
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"RT-PCR revealed that the expression levels of p53, Bax and Beclin 1 were up-regulated in a dose dependent manner, indicating that Beclin 1 was involved in Rapa induced autophagy and Rapa induced apoptosis as well as p53 up-regulation in PC-2 cells."
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"Additionally, forced overexpression of p53 increases both Drp1 expression and its mitochondrial localization in H1299 p53 -/- cells."
TP53 bound to E6 activates TP53. 4 / 4
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"The E6 protein binding to p53 causes p53 inactivation by its degradation, turning off its function [XREF_BIBR, XREF_BIBR]."
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"The E6 protein binding to p53 causes p53 inactivation by its degradation [XREF_BIBR, XREF_BIBR]."
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"E6 binding to p53 can also lead to retention of p53 in the cytoplasm, blocking its translocation to the nucleus and hence abrogating its function independently of degradation [XREF_BIBR]."
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"The newly transformed cells stably express E6, which binds to p53 and recruits the E3 ligase E6AP to target p53 for proteasomal degradation, as well as E7, which recruits the E3 ligase cullin 2 to target pRb for proteasomal degradation."
TP53 bound to TP53BP2 activates TP53. 3 / 3
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"ASPP2 can bind to p53 and enhance the apoptotic capabilities of p53 by guiding it to the promoters of pro apoptotic genes."
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"The p53 binding protein 2 (p53BP2) that binds to both p53 and Bcl2, enhances the trans-activation function of p53 and may induce the cdk inhibitor p21."
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"3 ASPP2 binds to p53 through its C terminus to stimulate the transactivation function of p53 on the promoters of pro apoptotic genes, such as the genes encoding Bax, PIG3 and PUMA."
TP53 bound to DMP1 activates TP53. 3 / 3
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"Together, our findings identify a robust new mechanism of p53 activation mediated through by direct physical interaction between Dmp1 and p53."
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"Together, our findings identify a robust new mechanism of p53 activation mediated by direct physical interaction between Dmp1 and p53."
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"We propose that the physical interaction between Dmp1 and p53 will synergize with Arf promoter activation by Dmp1 to enhance the activity of the p53 pathway."
TP53 bound to TP53BP1 activates TP53. 3 / 3
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"The mechanistic principles by which p53 interacts with 53BP1 and promotes accumulation of p53 at the sites of DNA damage may help in identification of new diagnostic markers and targets within cancer-critical p53 mediated signaling pathways."
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"53BP1 binds to p53 and enhances p53 mediated transcriptional activation."
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"Because 53BP1 binds to p53 and enhances p53 mediated transcriptional activity, 53BP1 mediated regulation of mitochondrial function might be required for p53 to function properly."
TP53 bound to HTT activates TP53. 2 / 2
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"Mutant huntingtin binds to p53 and upregulates the levels of nuclear p53 as well as p53 transcriptional activity in neuronal cultures."
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"Mutant huntingtin (mHtt) with expanded polyglutamine (polyQ) binds to p53 and upregulates levels of nuclear p53 as well as p53 transcriptional activity in neuronal cultures."
TP53 bound to X activates TP53. 2 / 2
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"The binding of HBx to p53 modulated (but did not inhibit) the transcriptional activation function of p53."
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"HBx causes transcriptional repression of the p53 gene and interacts with p53 to inactivate several important p53 dependent activities, including apoptosis, cell-cycle regulation, DNA repair and tumor suppression."
TP53 bound to Cofilin activates TP53. 2 / 2
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"Second, S3A cofilin preferentially formed a complex with p53 and promoted the localization of p53 not only to mitochondria but also to the nucleus, resulting in further transcription of p53 responsive genes and promotion of p53 induced cell death."
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"In this study, we showed for the first time that cofilin forms a complex with p53, with S3A cofilin preferentially interacting with p53 and promoting the nuclear translocation of p53."
TP53 bound to NQO1 activates TP53. 2 / 2
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"NQO1 has protective effect against the development of Alzheimer 's disease as well as binds to p53 and inhibits p53 degradation in an ubiquitin independent pathway via the 20S proteasome."
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"In contrast, dicumarol, and other inhibitors that compete with NAD (P) H, disrupted the binding of NQO1 and p53 and caused ubiquitin independent p53 degradation [XREF_BIBR, XREF_BIBR], whereas binding of NQO1 to p53 (and p73alpha, see below) was enhanced by addition of NADH, but not by NAD or FAD [XREF_BIBR]."
TP53 bound to ELAVL1 activates TP53. 2 / 2
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"Binding of HuR to the p53 mRNA 3 ' UTR, especially at a site adjacent to the miR-125b target site, causes dissociation of the p53 mRNA from the RNA induced silencing complex (RISC) and inhibits the miR-125b-mediated translation repression of p53."
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"According to this competitive interaction, when 7SL was silenced, HuR binding to TP53 mRNA was increased, which subsequently promoted p53 translation, resulting in increased cell cycle arrest and senescence [XREF_BIBR]."
TP53 bound to MIF activates TP53. 2 / 2
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"Conversely, the HIF-1alpha target MIF can bind to p53 directly and inhibit many p53 dependent responses, senescence included."
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"The interaction of MIF and p53 promotes the association of p53 with Mdm2 and thus leading to the ubiquitination of p53 and its proteasome mediated degradation."
TP53 bound to MDM4 activates TP53. 2 / 2
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"13 Although MDMX is highly homologous to MDM2, Nutlin is inefficient in interrupting the transcription-repressive MDMX and p53 complex, which prevents p53 transcriptional activity in numerous cancer cell lines, including retinoblastomas, which harbor MDMX upregulation."
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"The association between MDM4 and p53 is evidenced in the cytoplasmic compartment, supporting the role of cytoplasmic stabilization of p53 during its activation."
TP53 bound to RPL26 activates TP53. 2 / 2
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"Moreover, it has been shown that RPL26 binds the 5 '-UTR of p53 mRNA and activates p53 translation after DNA damage."
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"On the other hand, RPL5 and RPL26 bind p53 mRNA to enhance p53 synthesis."
TP53 bound to it activates TP53. 2 / 2
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"For example, it has been shown that DAXX interacts with p53 and promotes p53 dependent apoptosis."
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"Then, it enters the nucleus and directly binds p53 through its GST domain, disrupts the MDM2-p53 association, and thereby blocks MDM2 mediated ubiquitylation and degradation of p53 [XREF_BIBR]."
TP53 bound to PIN1 activates TP53. 2 / 2
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"Another p53 binding protein is Pin1, which upon DNA damage induced phosphorylation of p53, binds to p53 and mediates a conformational change of p53 resulting in enhanced p53 transcriptional activity XREF_BIBR."
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"PIN1 interacts with p53 to enhance protein stability and transactivation activity of p53 to promote cellular apoptosis in response to DNA damage [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
TP53 phosphorylated on S15 activates TP53. 2 / 2
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"p53S15 phosphorylation is known to increase the transactivating function of p53 37 and thus may contribute to transcriptional activation of the bax gene 38 and apoptosis induction 21."
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"In the classical model, N-terminal phosphorylation of p53 at Ser 15 (mouse Ser 18) and Ser 20 (mouse Ser 23) inhibits the interaction with MDM2 and thereby prevents MDM2 mediated ubiquitination and the resulting proteasomal degradation of p53 [XREF_BIBR] (XREF_FIG)."
Modified mutated TP53 activates TP53. 1 / 1
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"We show here that overexpression of the GOF mutant p53 G245D and other GOF p53 mutants enhances the invasive cell growth of p53 deficient head and neck squamous cell carcinoma (HNSCC) UM-SCC-1 cells both in in vitro three-dimensional culture and in an in vivo orthotopic nude mouse model of HNSCC through a novel transcription independent mechanism."
TP53 bound to BCL2L12 activates TP53. 1 / 1
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"Nuclear BCL2L12 physically interacts with p53 to form a complex, and thus eliminates the tumor suppression of p53 XREF_BIBR XREF_BIBR."
TP53 bound to HMGB1 activates TP53. 1 / 1
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"Recent works have demonstrated that binding between HMGB1 and p53 enhances p53 mediated transcriptional activity."
TP53 bound to STAT1 activates TP53. 1 / 1
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"In B cells, STAT1 physically interacts with p53, modulates p53 activity and sensitizes the cells to fludarabine induced apoptosis 24."
TP53 bound to TP53BP2 activates TP53. 1 / 1
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"ASPP2 and its RVXF-containing homolog ASPP1 also bind to p53 and thereby specifically stimulate the transactivation of proapoptotic genes by p53 (310), but addition of PP1 dissociated p53 from the COOH-terminal half of ASPP2 (163), leaving the function of the PP1-ASSP interaction unknown."
TP53 bound to it and GST domain activates TP53. 1 / 1
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"Then, it enters the nucleus and directly binds p53 through its GST domain, disrupts the MDM2-p53 association, and thereby blocks MDM2 mediated ubiquitylation and degradation of p53 [XREF_BIBR]."
TP53 bound to NPM1 activates TP53. 1 / 1
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"Here we show that NPM interacts directly with the tumour suppressor p53, regulates the increase in stability and transcriptional activation of p53 after different types of stress, and induces p53 dependent premature senescence on overexpression in diploid fibroblasts."
TP53 phosphorylated on S366 activates TP53. 1 / 1
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"Intriguingly, C-terminal phosphorylation of p53 at both Ser 366 and Ser 378 enhances the association with BZLF1 protein and subsequent ubiquitination of p53 XREF_BIBR, possibly through the phosphorylation induced conformational change of p53."
TP53 bound to IVNS1ABP activates TP53. 1 / 1
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"We hypothesized that both compromised ubiquitination of p53 and NS1 interaction may contribute towards IAV induced stabilization of p53, but the underlying mechanisms remained unveiled."
TP53 bound to IFI16 activates TP53. 1 / 1
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"Several reports show that IFI16 interacts with p53 and enhances the transcriptional activation function of p53 [XREF_BIBR, XREF_BIBR]."
TP53 bound to SMARCA4 activates TP53. 1 / 1
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"suggested that the BRG-1 interacts with p53 and activates the p21 CIP1 and WAF1 promoter in a p53 dependent manner."
TP53 bound to Certain proteins activates TP53. 1 / 1
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"Certain proteins bind to p53 and increase the stability of p53 by preventing p53 from undergoing ubiquitination via interaction with Mdm2."
TP53 bound to DNM1L activates TP53. 1 / 1
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"Cytoplasmic p53 binds to Drp1 and induces co-accumulation of Drp1 and p53 at mitochondria, leading to Drp1 hyperactivation and subsequent excessive mitochondrial fission and dysfunction (ROS production, loss of DeltaPsim) and neuronal necrosis."
TP53 bound to HSP90 activates TP53. 1 / 1
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"Recent studies have reported that HSP90 can bind to mutp53 and reduce mutp53 degradation mediated by MDM2."
TP53 bound to NOC2L activates TP53. 1 / 1
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"NIR (novel INHAT repressor) can bind to p53 at promoters and inhibit p53 mediated gene transactivation by blocking histone acetylation carried out by p300 and CBP."
TP53 bound to UCHL1 activates TP53. 1 / 1
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"We further found that UCHL1 formed a complex with p53 and p14 (ARF)/Mdm2 p53 binding protein homolog (mouse), MDM2 and activated the p53 signaling pathway."
TP53 bound to S100A4 activates TP53. 1 / 1
| 1
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"Recently, Grigorian et al demonstrated that S100A4 interacts with the tumor suppressor protein p53 to enhance p53 dependent apoptosis."
TP53-G245D activates TP53. 1 / 1
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"We show here that overexpression of the GOF mutant p53 G245D and other GOF p53 mutants enhances the invasive cell growth of p53 deficient head and neck squamous cell carcinoma (HNSCC) UM-SCC-1 cells both in in vitro three-dimensional culture and in an in vivo orthotopic nude mouse model of HNSCC through a novel transcription independent mechanism."
TP53 bound to hUTP14a activates TP53. 1 / 1
| 1
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"We showed that hUTP14a physically interacts with p53 and functionally promotes p53 turn-over, and that hUTP14a promotion of p53 destabilization is sensitive to a proteasome inhibitor but independent of ubiquitination."
TP53 activates ubiquitinated TP53. 1 / 1
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"Wt-ING1 stabilized both ubiquitinated and non ubiquitinated forms of p53 (XREF_FIG, lane 2), while MDM2 only increased levels of p53 monoubiquitinated on several residues (XREF_FIG, top panel, lane 5), but failed to promote accumulation of non ubiquitinated p53 (XREF_FIG, third panel, lane 5)."
TP53 bound to NME1 activates TP53. 1 / 1
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"Here we show that NM23-H1 and its binding partner STRAP (serine threonine kinase receptor associated protein) interact with p53 and potentiate p53 activity."
TP53 bound to FOXO4 activates TP53. 1 / 1
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"Alternatively, FOXO4 binding to p53 can interfere with p53 binding to different co-repressors and therefore increase p53 activity."
TP53 bound to Melk activates TP53. 1 / 1
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"Because MPK38 interacted with p53 and stimulated p53 signaling XREF_BIBR, we determined whether ZPR9 has an effect on MPK38 induced p53 activity."
TP53 bound to E2F1 activates TP53. 1 / 1
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"These results suggest that the binding of E2F1 to p53 can specifically stimulate the apoptotic function of p53 in response to DNA damage."
TP53 bound to SETD3 activates TP53. 1 / 1
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"SETD3 binds p53 in cells in response to doxorubicin treatment and positively regulates p53 target genes activation under these conditions."
TP53 bound to ECD activates TP53. 1 / 1
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"ECD binds to p53, stabilizes it and enhances p53 function when overexpressed [XREF_BIBR]."
TP53 bound to Small Ribosomal Subunit activates TP53. 1 / 1
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"A Small Ribosomal Subunit (SSU) Processome Component, the Human U3 Protein 14A (hUTP14A) Binds p53 and Promotes p53 Degradation *."
TP53 bound to KLF4 activates TP53. 1 / 1
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"Overall, these results indicate that the interaction between KLF4 and p53 enhances only the specific binding of p53 to DNA."
TP53 bound to RPA activates TP53. 1 / 1
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"Exposure of p53 and RPA complex to either damage activated protein kinases that hyperphosphorylate RPA32N or to large amounts of ssDNA would stimulate release of active p53."
TP53 bound to TTC5 and serine activates TP53. 1 / 1
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"Here we show that NM23-H1 and its binding partner STRAP (serine threonine kinase receptor associated protein) interact with p53 and potentiate p53 activity."
Mutated TP53 bound to BAG5 activates mutated TP53. 1 / 1
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"A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis."
TP53 bound to region activates TP53. 1 / 1
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"Analysis of the Pparg gene sequence identified a consensus activating p53 RE in an intronic region between exons 12 and 13, and ChIP analyses determined that p53 associated with this region."
TP53 bound to DAXX activates TP53. 1 / 1
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"For example, it has been shown that DAXX interacts with p53 and promotes p53 dependent apoptosis."
TP53 bound to ZFHX3 activates TP53. 1 / 1
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"ZFHX3 directly interacts with TP53 to activate the CDKN1A promoter (p21 Cip1), leading to cell cycle arrest, and thus ZFHX3 loss buffers this TP53 activity 47."
Mutated TP53 activates TP53-R270H. 1 / 1
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"Consistently, we found that decreased expression of mutant p53 by FDXR deficiency inhibited mutant p53 R270H to induce carcinoma and high grade pleomorphic sarcoma in FDXR +/-; p53 R270H/- mice as compared with p53 R270H/- mice."
TP53 phosphorylated on S20 activates TP53. 1 / 1
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"Evidence suggests that phosphorylation of p53 at Ser20 leads to inhibition of the p53 and MDM2 interaction, preventing ubiquitin mediated p53 degradation and thereby enhancing p53 stabilisation [XREF_BIBR - XREF_BIBR]."
TP53 bound to S100A2 activates TP53. 1 / 1
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"Intriguingly, S100A2 could interact with p53 in a calcium dependent manner and activate p53 transcriptional activity, which presumably helps restore p53 function in cell arrest and apoptosis [XREF_BIBR]."
Modified TP53 activates TP53-R172H. 1 / 1
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"As shown in XREF_FIG, expression of mutp53 greatly increased the levels of RhoA-GTP but not the total RhoA in H1299 and p53 R172H and R172H MEF cells, and furthermore, knockdown of endogenous mutp53 greatly reduced the levels of RhoA-GTP but not the total RhoA in MDA-MB468 and SK-BR3 cells."
TP53 bound to RPL5 activates TP53. 1 / 1
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"On the other hand, RPL5 and RPL26 bind p53 mRNA to enhance p53 synthesis."
TP53 bound to Hsp90alpha activates TP53. 1 / 1
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"The studies demonstrate that PRIMA-1 restores the p53-Hsp90alpha interaction, enhances the translocation of the p53 and Hsp90alpha complex and reactivates p53 transcriptional activity."
Modified TP53 activates mutated TP53. 1 / 1
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"The expression of wild-type p53 significantly increased TFAM transcript levels relative to mutant p53 (XREF_FIG)."
TP53 bound to RCHY1 activates TP53. 1 / 1
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"We also report that Pirh2 interacts with p53 via the CTD, which targets the p53 TET domain, and with possible enhancement from a weak interaction between the NTD and p53 DNA binding domain."
TP53-R175H activates TP53-R175H. 1 / 1
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"Surprisingly, Hsc70 knockdown in CAL33 cells neither altered p53 R175H levels nor affected lovastatin induced p53 R175H degradation (XREF_FIG)."
TP53 bound to ANXA1 activates TP53. 1 / 1
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"ANXA1 interacts with p53 and promotes p53 transcriptional activity, which in turn regulates Bid expression."
TP53 bound to hTOP3alpha activates TP53. 1 / 1
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"We concluded that hTOP3alpha interacts with p53, regulates p53 and p21 expression, and contributes to the p53 mediated tumor suppression."
TP53 bound to ASPP proteins activates TP53. 1 / 1
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"For example, ASPP proteins interact with p53 and enhance the DNA binding and transactivation function of p53 on the promoters of pro apoptotic genes, such as Bax and PIG-3."
TP53 bound to USP7 activates TP53. 1 / 1
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"Conflicting studies show that binding of p53 to USP7 either promotes the deubiquitination and subsequent stabilization of p53 [XREF_BIBR, XREF_BIBR] or that disruption of USP7 stabilizes p53 [XREF_BIBR, XREF_BIBR]."
TP53 bound to TP53, TP53, and TP53 activates TP53. 1 / 1
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" Ser392 phosphorylation of P53 increases 10-fold the association constant for tetramerization, but this effect is reversed by Ser315 phosphorylation. The tetramerization activates P53 for specific DNA binding and transcription"
TP53 bound to E1B 55-kDa protein activates TP53. 1 / 1
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"The adenovirus E1B 55-kDa protein binds to both p53 and E4orf6, and recruits a Cullin containing complex to direct the ubiquitin mediated proteolysis of p53 XREF_BIBR."
TP53 bound to TP63 activates TP53. 1 / 1
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"It could be useful to develop and validate reagents that interfere with mutp53 and p73 and mutp53 and p63 interactions restoring p53, p73, and p63 tumor suppression functions."
TP53 bound to RITA1 activates mutated TP53. 1 / 1
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"Using fluorescence anisotropic experiments, it was shown that RITA directly binds p53 and causes a conformational change that prevents the binding between p53 and MDM2, effectively inducing apoptosis in cells with wild-type p53, but not mutant p53 or null."
TP53 bound to NDN activates TP53. 1 / 1
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"Furthermore, necdin binds to the tumor suppressor protein p53 and inhibits p53 dependent apoptosis, whereas these two proteins suppress cell proliferation in an additive manner XREF_BIBR, XREF_BIBR."
TP53 bound to DACH1 activates TP53. 1 / 1
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"XREF_BIBR Recent studies demonstrated that DACH1 associated with p53 and enhanced p53 function to induce apoptosis and inhibit tumor growth."
TP53-R248W activates TP53. 1 / 1
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"Expression of the dominant negative p53 R248W mutant due to TM significantly reduced the transactivation of several established p53 target genes that mediate the tumor-suppressor function, including CDKN1A (p21) and BBC3 (PUMA)."
Mutated TP53 bound to Met-Gln activates TP53. 1 / 1
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"While MQ binding to mutant p53 can restore p53 dependent apoptosis, MQ binding to other cellular proteins may not necessarily have major effects on cell growth and survival, except for binding to TrxR and GSH and possibly other anti-oxidative proteins, as discussed above."
TP53 bound to IKKalpha promoter activates TP53. 1 / 1
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"Although p53 does not bind directly to the IKKalpha promoter, overexpressed p53 interacts with ETS-1 to repress IKKalpha, resulting in repression of NF-kappaB signaling XREF_BIBR."
TP53 bound to its activates TP53. 1 / 1
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"Cyclin G interacts with p53 as well as p73, and its binding to p53 or p73 presumably mediates downregulation of p53 and p73."
TP53 bound to Cofilin activates TP53. 1 / 1
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"Such actions may also explain our observation that PLD1 reduced the cofilin and p53 complex and inhibited cofilin-S3A-induced nuclear translocation of p53."
TP53 bound to TTC5 and threonine activates TP53. 1 / 1
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"Here we show that NM23-H1 and its binding partner STRAP (serine threonine kinase receptor associated protein) interact with p53 and potentiate p53 activity."
TP53 bound to EP300 activates TP53. 1 / 1
| 1
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"In contrast, the absence of CSB would increase the binding of p53 to p300 causing the stabilization of p53 and the activation of its target genes including the ones involved in the apoptotic commitment."
Mutated TP53 bound to TAAR1 activates TP53. 1 / 1
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"Binding of TAR1 to mutant p53 induced transcriptional transactivation of p53 target genes and down-regulation of mutant p53 transcriptional target genes."
TP53 bound to CLDN6 activates TP53. 1 / 1
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"We further confirmed that CLDN6 interacted with p53 and promoted translocation of p53 from nucleus to cytoplasm, and both the expression and enzyme activity of GSTP1 were regulated by p53."
TP53 bound to HSPA5 activates TP53. 1 / 1
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"Therefore, our current hypothesis is that the interaction between GRP78 and p53 abrogates the negative regulation of p53 on Nanog."
TP53 bound to 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazol-1-yl]-oxomethyl]-2-piperazinone activates TP53. 1 / 1
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"Nutlin 3A, a small-molecule antagonist that binds to the p53 binding pocket on Mdm2, potently blocks the p53-Mdm2 interaction and activates downstream p53 mediated transcriptional events [XREF_BIBR]."
TP53 bound to ATG7 activates TP53. 1 / 1
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"We further showed that in Cnot3 -depleted hearts, Atg7 interacted with p53 and modulated p53 activity to induce the expression of genes encoding cell death promoting factors in cardiomyocytes, indicating that defects in deadenylation in the heart aberrantly activated Atg7 and p53 to promote cell death."
TP53 bound to TP73 activates TP53. 1 / 1
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"We observed that the small-molecule inhibitor Nutlin-3, which disrupts the interaction of p53 and p73 with MDM2, induces apoptotic cell death in p53 wild-type, as well as p53-mutant PEL cell lines, suggesting a possible involvement of p73."
TP53 bound to targets activates TP53. 1 / 1
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"Importantly, only a small subset of p53 targets are activated under specific conditions XREF_BIBR, indicating that either binding of p53 to targets XREF_BIBR - XREF_BIBR or trans-activation potential of p53 proteins XREF_BIBR, XREF_BIBR may be affected by accessory molecules."
TP53 bound to TRIM45 activates TP53. 1 / 1
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"The results presented in XREF_FIG suggest that TRIM45 might directly interact with p53 to activate p53 signaling."
TP53 phosphorylated on amino acid 15 activates TP53. 1 / 1
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"Phosphorylation of p53 at serine 15 attenuates MDM2 binding to p53 and thus promotes p53 stability 55."
TP53 bound to LMO4 activates TP53. 1 / 1
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"Furthermore, LMO4 can interact with p53 and inhibit p53 mediated inhibition of colony formation of breast cancer MDA-MB-453 cells."
Mutated TP53 bound to TAAR1 activates mutated TP53. 1 / 1
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"Binding of TAR1 to mutant p53 induced transcriptional transactivation of p53 target genes and down-regulation of mutant p53 transcriptional target genes."
TP53 bound to IGFBP7 activates TP53. 1 / 1
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"Our results suggest that direct interaction of TAF (II) 31 and p53 not only mediates p53 transcriptional activation but also protects p53 from mdm2 mediated degradation, thereby resulting in activation of p53 functions."
TP53 bound to HIF1A activates TP53. 1 / 1
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"Alternatively, HIF-1alpha can bind to the tumor suppressor p53 and promote p53 dependent apoptosis."
Mutated TP53 bound to pont activates mutated TP53. 1 / 1
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"The interaction of Pontin and mutant p53 promotes the binding of mutant p53 in the promoter region of its regulated genes."
TP53 bound to MPG activates TP53. 1 / 1
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"MPG directly binds to the tumor suppressor p53 and represses p53 activity in unstressed cells."
TP53 bound to inhibitory factor activates TP53. 1 / 1
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"Macrophage inhibitory factor itself can bind to p53 and inhibit p53 function."
TP53 bound to PTK2 activates TP53. 1 / 1
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"We identified novel small molecules targeting the FAK and p53 interaction that were able to activate p53 (discussed below)."
TP53 bound to circ-Ccnb1 activates TP53. 1 / 1
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"In breast cancer, circ-Ccnb1 binds H2AX and wild-type p53 to enable p53 wild-type cell survival."