A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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"Lymphotoxin competitively, but not completely, inhibited TNF induced differentiation."
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"Tumor Necrosis Factor Alpha Induces Reactivation of Human Cytomegalovirus Independently of Myeloid Cell Differentiation following Posttranscriptional Establishment of Latency."
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"These results suggest that TNF-alpha might induce osteoclast differentiation in the absence of TRANCE-RANK interactions."
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"TNF-alpha enhances T and B cell proliferation and differentiation, and increases Natural killer (NK) cell activity [XREF_BIBR]."
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"Th1 profile cytokines, such as IL-2, INF-gamma, and TNF-alpha, which promote differentiation of naive T lymphocytes and macrophages, as well as the cytokines -- TGF-beta, IL-17, and IL-23 -- and Treg lymphocytes are involved in the pathogenesis of the type I reaction or reverse reaction."
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"Tumor necrosis factor-alpha (TNF-alpha) induces both rapid onset of apoptosis and monocytic differentiation in HL-60 human myeloid leukemia cells."
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"In addition, it was shown that IL-1beta, IL-6, and TNF-alpha can promote the differentiation of Th22 cells from naive CD4+ T cells and that combinations of these cytokines promote differentiation at more pronounced levels [XREF_BIBR]."
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"CD40L caused the DCs to mature and secrete high levels of TNF-alpha and IL-12, proinflammatory cytokines that promote the differentiation of Th1 T cells."
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"Determination of soluble TNF receptor levels, especially p55, might enable differentiation of rheumatoid arthritis from osteoarthritis and gout."
TNF activates cell differentiation. 1 / 3
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"A variety of angiogenesis inducers have been described (Table 2), which can be divided in three classes (129). The first class consists of the VEGF family and the angiopoietins, which specifically act on endothelial cells. The second class contains most direct-acting molecules, including several cytokines, chemokines (157) and angiogenic enzymes (30, 39), which activate a broad range of target cells besides endothelial cells. The prototype member of this group, FGF-2 was one of the first angiogenic peptides to be characterized. The third group of angiogenic molecules includes the indirect-acting factors, whose effect on angiogenesis results from the release of direct-acting factors from macrophages, endothelial or tumor cells. The most extensively studied are tumor necrosis factor-a (TNF-a) and transforming growth factor-b (TGF-b), which inhibit endothelial cell proliferation in vitro. In vivo, TGF-b induces angiogenesis and stimulates the expression of TNF-a, FGF-2, platelet derived growth factor (PDGF) and VEGF by attracted inflammatory cells (63, 185). TNF-a has been shown to increase the expression of VEGF and its receptors, interleukin-8 (IL-8) and FGF-2 by endothelial cells, thus explaining its angiogenic properties in vivo (87, 261)."
TNF bound to TNFRSF1A activates cell differentiation. 1 / 1
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"These results are consistent with the observation that TNFalpha binding to TNFR-1 on osteoblasts triggers ostoclast differentiation and subsequent bone destruction XREF_BIBR."