A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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TNF activates ERK. 10 / 759
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"The TNFalpha-induced activation of ERK1/2 was specifically prevented by compound PD 98059 a specific inhibitor of the MAP kinase kinase MEK1/2."
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"Although none of the treatments affected ERK phosphorylation after 1 hour (data not shown), by 6 hours both TVX and TVX and TNF treatments led to an increase in ERK activation compared to cells treated with vehicles or TNF (XREF_FIG)."
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"TNFalpha activates MAPK and NFkappaB pathways XREF_BIBR XREF_BIBR, and our data suggest that the MAPK rather than the NFkappaB pathway contribute controls OPG by TNFalpha signaling (XREF_SUPPLEMENTARY)."
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"Mechanistically, MADD siRNA inhibited TNFα induced activation of pERK, pGSK3β and β-catenin, suggesting that MADD knockdown might exert its anti-migratory/invasive effects, by blocking TNFα/ERK/GSK3β axis."
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"This observation raises the possibility that MMP9 expression can be promoted through TNFα-induced ERK activation when WASF3 levels are repressed."
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"Although ERK and AKT inactivation was also noted in the presence of SHH inhibitors, these kinases were not significantly activated upon TNF-alpha stimulation of IEC-6 cells (in colon cancer cells HCT-116, ERK and AKT were significantly activated by TNF-alpha and significantly inactivated by SHH inhibitors; data not shown)."
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"Considering that the p44 and p42 extracellular signal-related kinases (ERK 1 and 2) can be activated by TNF in BAE cells and that their activation is associated with inhibition of apoptosis in some c[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
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"The present data indicate that TNF-alpha activation of PKCzeta and iota, p42/44 MAPK, c-Jun/AP-1, and p65 and NF-kappaB are involved in TNF-alpha-stimulated MC fractalkine expression, with the soluble fractalkine mediating in part the TNF-alpha-induced monocyte transmigration in vitro."
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"As described herein, TNF-α activates PKCδ, ERK1/2, and JNK2 in RA synovial fibroblasts."
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"These data are in agreement with other authors who documented that in human lung cells, TNF-alpha and IL-1beta induce the activation of NF-kappaB and MAPK signaling pathways."
TNF activates phosphorylated ERK. 10 / 13
| 13
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"Mechanistically, MADD siRNA inhibited TNFalpha induced activation of pERK, pGSK3beta and beta-catenin, suggesting that MADD knockdown might exert its anti-migratory and invasive effects, by blocking TNFalpha/ERK/GSK3beta axis."
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"TNF-alpha treatment increased pERK in small- and medium sized DRG neurons and to a lesser degree in large neurons."
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"Artemisinin significantly inhibited the protein level of phosphorylated ERK1/2 and p38 MAPK induced by TNF-alpha in the HUVECs at all concentrations tested, while the inhibition of the phosphorylation of JNK was only observed at the high concentrations (100 and 200 microM) (XREF_FIG)."
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"Icariin treatment resulted in a reduced expression of p-P38 and p-ERK signal activation induced by TNF-alpha and IFN-gamma; however, only SB203580, the p38 alpha/beta inhibitor, inhibited the secretion of inflammatory cytokines induced by TNF-alpha and IFN-gamma in cultured HaCaT cells."
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"Topical application of TNF-alpha to rat nerve root increased pERK in ipsilateral dorsal root ganglion (DRG) neurons and glia within 5 hours."
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"To determine whether the different patterns of pERK required newly synthesized proteins, cells were treated with cycloheximide and TNFalpha."
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"In contrast, neither the steady-state levels nor the TNF-alpha or IL-1beta induction of pJNK or pERK were affected by culturing RA synovial fibroblasts with 3 muM lovastatin."
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"The strong activation of p-ERK by EGF at both 10 and 30 min post-stimulation results in the p-ERK coefficients projecting towards the EGF scores (compare in XREF_FIG), while the strong activation of the p38 pathway by IL-1alpha and TNFalpha results in the p-p38 coefficients projecting towards the IL-1alpha and TNFalpha scores (compare in XREF_FIG)."
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"Similarly, the protein levels of p-JNK, JNK, p-ERK1/2, and ERK1/2 were relatively stable in hNPCs treated with TNF-alpha for different durations."
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"However, Digibind could attenuate or reduce TNFalpha induced endothelial adhesion molecule expression, but had no effects on TNFalpha induced pERK upregulation."
TNF bound to TNFRSF1A activates ERK. 2 / 2
| 2
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"TNFRI 206-211 does not prevent TNF binding to TNFRI or TNF induced stimulation of ERK, JNK and NF-kappaB."
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"TNF binds to TNFR1, which induces NF-kB signaling and induces both MAPK pro inflammatory signaling and apoptosis."
TNF bound to TLR2 activates ERK. 1 / 1
| 1
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"Previous studies also showed that the secretion of IL-6, IL-1beta, and TNF-alpha was associated with TLR2 activated MAPK (ERK1/2, JNK, p38 MAPK) and NF-kappaB signaling pathways [XREF_BIBR - XREF_BIBR]."
TNF bound to its activates ERK. 1 / 1
| 1
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"TNF binding to its receptors activates NFkappaB and MAPK signaling, inducing the expression of downstream pro inflammatory genes."
TNF bound to TNF activates ERK. 1 / 1
| 1
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"TNFalpha binds to TNF receptor 1 and 2 (TNFR1, TNFR2) and signals with different intracellular TRAFs, ultimately activating MAPK and NFkappaB, and results in the expression of other cytokines, adhesion and co-stimulatory molecules [XREF_BIBR, XREF_BIBR]."
TNF bound to TNF receptor activates ERK. 1 / 1
| 1
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"TNFalpha binds to TNF receptor 1 and 2 (TNFR1, TNFR2) and signals with different intracellular TRAFs, ultimately activating MAPK and NFkappaB, and results in the expression of other cytokines, adhesion and co-stimulatory molecules [XREF_BIBR, XREF_BIBR]."
TNF activates ERK. 1 / 1
1 |
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"In vitro kinase assay... As demonstrated in Fig. 4b, PMA induced rapid activation of MAPKerk1/2 at 15 min, consistent with the Western blot information. TNF-a-induced activation of MAPKerk1/2 was detected by 60 min."
TNF bound to EGFR activates ERK. 1 / 1
| 1
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"Signaling transduction study and coimmunoprecipitation suggested that TNF-alpha interacts with EGF receptor to activate ERK1/2 pathway."